CRCGN017_MCF10A.TP53.M_24H:M22 Gene Set
Dataset
Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category
transcriptomics
Type
small molecule perturbation
Description
(3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 103.32 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome )
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Genes
19 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
Symbol
Name
Standardized Value
CASP2
caspase 2, apoptosis-related cysteine peptidase
4.37231
MAMLD1
mastermind-like domain containing 1
4.03925
PPARG
peroxisome proliferator-activated receptor gamma
3.44257
MAP7
microtubule-associated protein 7
3.39389
TXNL4B
thioredoxin-like 4B
2.8086
AGR2
anterior gradient 2
2.35934
HBB
hemoglobin, beta
2.28624
BMP4
bone morphogenetic protein 4
2.24268
MTA2
metastasis associated 1 family, member 2
2.10998
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
2.08819
decreased expression
Symbol
Name
Standardized Value
BASP1
brain abundant, membrane attached signal protein 1
-4.07481
GRWD1
glutamate-rich WD repeat containing 1
-3.5921
TM9SF2
transmembrane 9 superfamily member 2
-3.32758
LYPLA1
lysophospholipase I
-3.24217
BPHL
biphenyl hydrolase-like (serine hydrolase)
-3.23607
TRAPPC8
trafficking protein particle complex 8
-2.20693
HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
-2.12309
GBP2
guanylate binding protein 2, interferon-inducible
-2.04117
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
-2.03495
