CRCGN017_MCF10A.TP53.M_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 34.44 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.164
ABHD4 abhydrolase domain containing 4 4.0232
SMIM40 small integral membrane protein 40 3.96845
GARRE1 granule associated Rac and RHOG effector 1 2.979
PRKX protein kinase, X-linked 2.87727
CORO1A coronin, actin binding protein, 1A 2.85695
UGDH UDP-glucose 6-dehydrogenase 2.8416
TXNL4B thioredoxin-like 4B 2.7102
CNPY3 canopy FGF signaling regulator 3 2.6893
GPC1 glypican 1 2.64455
PMM2 phosphomannomutase 2 2.60945
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.58815
TBPL1 TBP-like 1 2.495
L1TD1 LINE-1 type transposase domain containing 1 2.47445
CAPN1 calpain 1, (mu/I) large subunit 2.4254
ARHGAP11A Rho GTPase activating protein 11A 2.41095
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.37865
EPN2 epsin 2 2.3633
H1-5 H1.5 linker histone, cluster member 2.33785
SHROOM2 shroom family member 2 2.3318
ELAC2 elaC ribonuclease Z 2 2.28955
VAMP5 vesicle-associated membrane protein 5 2.2854
CUZD1 CUB and zona pellucida-like domains 1 2.2741
MAGEB4 melanoma antigen family B4 2.27165
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.2716
TLR7 toll-like receptor 7 2.2654
UBIAD1 UbiA prenyltransferase domain containing 1 2.2407
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.2364
DCC DCC netrin 1 receptor 2.22575
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.2113
INSM1 insulinoma-associated 1 2.2098
THAP9 THAP domain containing 9 2.20795
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.18805
RPGRIP1L RPGRIP1-like 2.184
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.18075
GYS2 glycogen synthase 2 (liver) 2.17845
GPR18 G protein-coupled receptor 18 2.1749
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.17397
RBP4 retinol binding protein 4, plasma 2.17075
MMP2 matrix metallopeptidase 2 2.17015
KLHDC2 kelch domain containing 2 2.1612
CEP97 centrosomal protein 97kDa 2.1524
ZNF74 zinc finger protein 74 2.1511
LRRTM4 leucine rich repeat transmembrane neuronal 4 2.14875
CPA1 carboxypeptidase A1 (pancreatic) 2.14615
DCAF17 DDB1 and CUL4 associated factor 17 2.1448
TRIM13 tripartite motif containing 13 2.1435
GTPBP10 GTP-binding protein 10 (putative) 2.14205
FAM13C family with sequence similarity 13, member C 2.1198
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.11628
DHODH dihydroorotate dehydrogenase (quinone) 2.11578
MELK maternal embryonic leucine zipper kinase 2.1136
TLR5 toll-like receptor 5 2.11335
RPE65 retinal pigment epithelium-specific protein 65kDa 2.1126
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.10865
MTAP methylthioadenosine phosphorylase 2.10718
EXOSC5 exosome component 5 2.10575
TMEM19 transmembrane protein 19 2.10225
RAI14 retinoic acid induced 14 2.1018
AIRIM AFG2 interacting ribosome maturation factor 2.1012
PRDM13 PR domain containing 13 2.0944
H2BC17 H2B clustered histone 17 2.09195
FETUB fetuin B 2.09115
CNTN5 contactin 5 2.0889
CPA4 carboxypeptidase A4 2.0878
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.08
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.07655
FLG filaggrin 2.0741
GPR65 G protein-coupled receptor 65 2.07325
HTATSF1 HIV-1 Tat specific factor 1 2.06765
MYEF2 myelin expression factor 2 2.06555
AFAP1 actin filament associated protein 1 2.0655
SORCS3 sortilin-related VPS10 domain containing receptor 3 2.0628
SNTG2 syntrophin, gamma 2 2.06265
AFM afamin 2.05655
RPAP2 RNA polymerase II associated protein 2 2.0551
ZNF234 zinc finger protein 234 2.05205
ZNF668 zinc finger protein 668 2.0495
IPO13 importin 13 2.0481
NOL10 nucleolar protein 10 2.04605
SH3GL1 SH3-domain GRB2-like 1 2.0428
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.0383
FAM135A family with sequence similarity 135, member A 2.03475
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 2.0333
PEX14 peroxisomal biogenesis factor 14 2.02558
FLT3LG fms-related tyrosine kinase 3 ligand 2.02472
MARCHF1 membrane associated ring-CH-type finger 1 2.02365
ZFP37 ZFP37 zinc finger protein 2.02245
TLL1 tolloid-like 1 2.02115
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.02065
HAL histidine ammonia-lyase 2.01982
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.0142
PNLIP pancreatic lipase 2.00905
THAP7 THAP domain containing 7 2.00515
PITX2 paired-like homeodomain 2 2.00455
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.0007
RASA2 RAS p21 protein activator 2 2.0006

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.3636
DNM1L dynamin 1-like -4.611
KDM3A lysine (K)-specific demethylase 3A -4.2515
LOC112694756 uncharaterized LOC112694756 -4.23285
NT5DC2 5'-nucleotidase domain containing 2 -3.46
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.42285
CAB39 calcium binding protein 39 -3.18445
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.1475
ERGIC2 ERGIC and golgi 2 -2.9665
CAPRIN2 caprin family member 2 -2.90945
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.62495
OAT ornithine aminotransferase -2.3985
TSPAN3 tetraspanin 3 -2.2637
HSPA1A heat shock 70kDa protein 1A -2.24925
OXA1L oxidase (cytochrome c) assembly 1-like -2.24255
STK25 serine/threonine kinase 25 -2.2085
CRTAP cartilage associated protein -2.1884
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.1412
DPP3 dipeptidyl-peptidase 3 -2.1293
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.06485
SRSF9 serine/arginine-rich splicing factor 9 -2.0573
INTS13 integrator complex subunit 13 -2.0529
MSN moesin -2.0336
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -2.02475
MLEC malectin -2.017