CRCGN017_MCF10A.TP53.M_24H:N04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 98.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 4.37195
HBA1 hemoglobin, alpha 1 2.8106
SCRIB scribbled planar cell polarity protein 2.5969
ZBTB35 zinc finger and BTB domain containing 35 2.55864
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.41334
CPOX coproporphyrinogen oxidase 2.13899
TMEM9B TMEM9 domain family, member B 2.05863
AUH AU RNA binding protein/enoyl-CoA hydratase 2.03071

decreased expression

Symbol Name Standardized Value
SCYL3 SCY1-like 3 (S. cerevisiae) -5.42961
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.84872
DNM1L dynamin 1-like -4.72446
BAG3 BCL2-associated athanogene 3 -3.94352
RXYLT1 ribitol xylosyltransferase 1 -3.67121
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.25698
MED21 mediator complex subunit 21 -2.94708
NRIP1 nuclear receptor interacting protein 1 -2.8846
INTS13 integrator complex subunit 13 -2.78178
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.57944
LEMD3 LEM domain containing 3 -2.30339
MLF2 myeloid leukemia factor 2 -2.14948
GPS1 G protein pathway suppressor 1 -2.11547
GRWD1 glutamate-rich WD repeat containing 1 -2.09841
CAPRIN2 caprin family member 2 -2.03348