CRCGN017_MCF10A.TP53.M_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 32.93 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.07155
SPAG4 sperm associated antigen 4 5.01424
TIAM1 T-cell lymphoma invasion and metastasis 1 3.36933
MCUR1 mitochondrial calcium uniporter regulator 1 3.28824
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.23076
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.55718
TRAM2 translocation associated membrane protein 2 2.48754
MGST2 microsomal glutathione S-transferase 2 2.24218
TPD52L2 tumor protein D52-like 2 2.07021
EVL Enah/Vasp-like 2.03377

decreased expression

Symbol Name Standardized Value
RPIA ribose 5-phosphate isomerase A -5.34914
DIPK1A divergent protein kinase domain 1A -5.12263
BASP1 brain abundant, membrane attached signal protein 1 -5.01343
HMG20B high mobility group 20B -4.87493
CCNB1 cyclin B1 -4.67427
SLC35F2 solute carrier family 35, member F2 -4.35654
GDF15 growth differentiation factor 15 -4.2668
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.69054
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.57209
PSIP1 PC4 and SFRS1 interacting protein 1 -3.13894
PFN1 profilin 1 -3.06397
THAP11 THAP domain containing 11 -2.83483
PTPRK protein tyrosine phosphatase, receptor type, K -2.16063
SH3GL1 SH3-domain GRB2-like 1 -2.11754
COPS7A COP9 signalosome subunit 7A -2.09148
SLC12A8 solute carrier family 12, member 8 -2.0617
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.03633