CRCGN017_MCF10A.TP53.M_24H:N06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 10.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

49 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 5.39548
LGMN legumain 5.14832
LYN LYN proto-oncogene, Src family tyrosine kinase 4.48823
ACAA1 acetyl-CoA acyltransferase 1 3.89153
ABHD6 abhydrolase domain containing 6 3.54861
SQOR sulfide quinone oxidoreductase 3.49768
GATA3 GATA binding protein 3 3.2798
HOXA10 homeobox A10 2.95524
RBP4 retinol binding protein 4, plasma 2.88813
SPDEF SAM pointed domain containing ETS transcription factor 2.81517
HLA-DMA major histocompatibility complex, class II, DM alpha 2.74411
C5 complement component 5 2.66415
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.65633
CD302 CD302 molecule 2.4606
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.45436
ZNF589 zinc finger protein 589 2.40184
TERT telomerase reverse transcriptase 2.39864
STK10 serine/threonine kinase 10 2.39645
SYK spleen tyrosine kinase 2.32287
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.25177
APOE apolipoprotein E 2.23182
FAM174B family with sequence similarity 174, member B 2.22897
CCDC85B coiled-coil domain containing 85B 2.20732
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.20179
GSTM5 glutathione S-transferase mu 5 2.19239
PARK7 parkinson protein 7 2.18088
LIPC lipase, hepatic 2.16581
TPO thyroid peroxidase 2.13192
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 2.1216
LECT2 leukocyte cell-derived chemotaxin 2 2.1092
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.09025
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.07729
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.04946
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.04807
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.03131
MBL2 mannose-binding lectin (protein C) 2, soluble 2.00993
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.00613

decreased expression

Symbol Name Standardized Value
EXOSC4 exosome component 4 -4.26322
ZDHHC6 zinc finger, DHHC-type containing 6 -4.10679
CCNB2 cyclin B2 -3.70516
NT5DC2 5'-nucleotidase domain containing 2 -3.52003
TRIB3 tribbles pseudokinase 3 -3.03439
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.57846
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.56969
FN3KRP fructosamine 3 kinase related protein -2.42811
ANKRD10 ankyrin repeat domain 10 -2.20753
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.12272
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.0257
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -2.00647