CRCGN017_MCF10A.TP53.M_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylbenzene 100.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.17124
MYLK myosin light chain kinase 4.86985
IDE insulin-degrading enzyme 4.69512
CXCR4 chemokine (C-X-C motif) receptor 4 4.55585
CCDC92 coiled-coil domain containing 92 4.27783
STK10 serine/threonine kinase 10 4.27165
TBX2 T-box 2 3.49406
ALDOC aldolase C, fructose-bisphosphate 3.33803
AGR2 anterior gradient 2 3.33638
CHEK2 checkpoint kinase 2 3.16365
USP6NL USP6 N-terminal like 2.99883
LGMN legumain 2.88377
DENND2D DENN/MADD domain containing 2D 2.62826
TLCD3A TLC domain containing 3A 2.34783
CENPE centromere protein E, 312kDa 2.27414
CNN1 calponin 1, basic, smooth muscle 2.22012
IFT81 intraflagellar transport 81 2.20626
ACTG2 actin, gamma 2, smooth muscle, enteric 2.17785
PUS1 pseudouridylate synthase 1 2.0417

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -3.64609
TRIB3 tribbles pseudokinase 3 -3.35266
CYBRD1 cytochrome b reductase 1 -2.76987
GRN granulin -2.3618
MTERF3 mitochondrial transcription termination factor 3 -2.3408
SOAT2 sterol O-acyltransferase 2 -2.3231
LRRC42 leucine rich repeat containing 42 -2.17677
GDF15 growth differentiation factor 15 -2.07851
LBP lipopolysaccharide binding protein -2.06591
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -2.04356
MRPL18 mitochondrial ribosomal protein L18 -2.04117