CRCGN017_MCF10A.TP53.M_24H:N09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylbenzene 11.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.07696
MAMLD1 mastermind-like domain containing 1 4.44112
CLNS1A chloride channel, nucleotide-sensitive, 1A 4.08419
PRKCH protein kinase C, eta 3.27846
FBXL12 F-box and leucine-rich repeat protein 12 3.27342
RSF1 remodeling and spacing factor 1 2.88275
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.86629
UVRAG UV radiation resistance associated 2.75514
EPHB2 EPH receptor B2 2.68699
CAPN5 calpain 5 2.67692
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.62707
CPOX coproporphyrinogen oxidase 2.5729
ZNF227 zinc finger protein 227 2.52911
REL v-rel avian reticuloendotheliosis viral oncogene homolog 2.49928
H2AJ H2A.J histone 2.47765
LGSN lengsin, lens protein with glutamine synthetase domain 2.47093
PKN1 protein kinase N1 2.4588
NFE2L3 nuclear factor, erythroid 2-like 3 2.43687
UGT8 UDP glycosyltransferase 8 2.38879
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.35265
HHLA2 HERV-H LTR-associating 2 2.34095
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.33584
DOCK1 dedicator of cytokinesis 1 2.32815
MFSD6 major facilitator superfamily domain containing 6 2.30468
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.29805
FADD Fas (TNFRSF6)-associated via death domain 2.28756
GUCY2C guanylate cyclase 2C 2.26087
PLCE1 phospholipase C, epsilon 1 2.23333
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.23263
THAP12 THAP domain containing 12 2.19198
LY75-CD302 LY75-CD302 readthrough 2.18639
FGFR4 fibroblast growth factor receptor 4 2.18609
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.17296
MTM1 myotubularin 1 2.17235
CALML4 calmodulin-like 4 2.171
CD101 CD101 molecule 2.16903
ZXDC ZXD family zinc finger C 2.16117
WFDC1 WAP four-disulfide core domain 1 2.14508
PTPN9 protein tyrosine phosphatase, non-receptor type 9 2.13363
ITK IL2-inducible T-cell kinase 2.12499
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.10795
HNF4G hepatocyte nuclear factor 4, gamma 2.10216
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 2.09546
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.09242
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.08971
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.08181
AAMDC adipogenesis associated, Mth938 domain containing 2.08118
MEAK7 MTOR associated protein, eak-7 homolog 2.0504
IL2RA interleukin 2 receptor, alpha 2.04541
CCR7 chemokine (C-C motif) receptor 7 2.02613
SIRPG signal-regulatory protein gamma 2.02014
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.01709
GPA33 glycoprotein A33 (transmembrane) 2.01514
ANKRD40CL ANKRD40 C-terminal like 2.00988
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.00544

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.49894
DSG2 desmoglein 2 -4.74593
RNF167 ring finger protein 167 -3.08212
GDF15 growth differentiation factor 15 -2.85336
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.7165
IFRD2 interferon-related developmental regulator 2 -2.57651
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.2077
FASN fatty acid synthase -2.16642
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.11063
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.01566