CRCGN017_MCF10A.TP53.M_24H:N10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description griseofulvin 100.55 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

239 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.03761
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.60185
H2BC12 H2B clustered histone 12 4.50469
OXSR1 oxidative stress responsive 1 4.3147
WFS1 Wolfram syndrome 1 (wolframin) 4.14826
H2BC9 H2B clustered histone 9 3.52307
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.18956
CEMIP2 cell migration inducing hyaluronidase 2 3.14873
TNIP1 TNFAIP3 interacting protein 1 3.13022
VGLL4 vestigial-like family member 4 3.08759
CXCL3 chemokine (C-X-C motif) ligand 3 3.05188
H2AC6 H2A clustered histone 6 3.00081
UBQLN2 ubiquilin 2 2.99677
ELAC2 elaC ribonuclease Z 2 2.98092
TXNL4B thioredoxin-like 4B 2.88946
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.79474
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.79031
TOMM34 translocase of outer mitochondrial membrane 34 2.7659
ALAS1 5'-aminolevulinate synthase 1 2.74308
SQOR sulfide quinone oxidoreductase 2.726
BYSL bystin-like 2.66683
IER3 immediate early response 3 2.65556
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.64404
FAT1 FAT atypical cadherin 1 2.60243
TIAM1 T-cell lymphoma invasion and metastasis 1 2.6018
UBIAD1 UbiA prenyltransferase domain containing 1 2.59528
H1-2 H1.2 linker histone, cluster member 2.58942
POLR1G RNA polymerase I subunit G 2.58624
AATF apoptosis antagonizing transcription factor 2.5768
SQSTM1 sequestosome 1 2.56262
STXBP1 syntaxin binding protein 1 2.53046
C5AR1 complement component 5a receptor 1 2.52225
TERF2IP telomeric repeat binding factor 2, interacting protein 2.49302
TXLNA taxilin alpha 2.48449
OXTR oxytocin receptor 2.47283
EBNA1BP2 EBNA1 binding protein 2 2.45428
MYBBP1A MYB binding protein (P160) 1a 2.44717
GABPB1 GA binding protein transcription factor, beta subunit 1 2.41981
H2BC4 H2B clustered histone 4 2.41623
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.41411
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.39841
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.38904
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.35822
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.348
TXNRD1 thioredoxin reductase 1 2.34657
STK10 serine/threonine kinase 10 2.34449
ZFP69B ZFP69 zinc finger protein B 2.33641
PMP22 peripheral myelin protein 22 2.32494
RFTN1 raftlin, lipid raft linker 1 2.32071
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.31019
FTSJ3 FtsJ homolog 3 (E. coli) 2.30617
USP36 ubiquitin specific peptidase 36 2.29536
GDI1 GDP dissociation inhibitor 1 2.28404
C3AR1 complement component 3a receptor 1 2.28203
IRGQ immunity-related GTPase family, Q 2.28127
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.26308
SCCPDH saccharopine dehydrogenase (putative) 2.22263
KLC3 kinesin light chain 3 2.21975
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.2151
TIMP2 TIMP metallopeptidase inhibitor 2 2.20636
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.20636
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.20628
YARS1 tyrosyl-tRNA synthetase 1 2.18679
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.16821
TLR4 toll-like receptor 4 2.16812
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.16421
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.15487
SMIM40 small integral membrane protein 40 2.14235
CSF3 colony stimulating factor 3 (granulocyte) 2.1413
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 2.13392
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.13298
TLR8 toll-like receptor 8 2.13257
NOP16 NOP16 nucleolar protein 2.13044
ZHX2 zinc fingers and homeoboxes 2 2.12752
AQP9 aquaporin 9 2.12037
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.11635
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.11
MX1 MX dynamin-like GTPase 1 2.10769
RBM28 RNA binding motif protein 28 2.09639
CCL20 chemokine (C-C motif) ligand 20 2.09159
HBEGF heparin-binding EGF-like growth factor 2.08955
GATAD2A GATA zinc finger domain containing 2A 2.08826
IL15RA interleukin 15 receptor, alpha 2.07873
LIPG lipase, endothelial 2.07342
PLAUR plasminogen activator, urokinase receptor 2.0723
IL3 interleukin 3 2.06219
TEX10 testis expressed 10 2.05637
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 2.05609
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.04911
IL1B interleukin 1, beta 2.02904
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.0162
C4BPA complement component 4 binding protein, alpha 2.01478
STX4 syntaxin 4 2.01053
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.00169

decreased expression

Symbol Name Standardized Value
NLRP4 NLR family, pyrin domain containing 4 -5.33707
HOXA5 homeobox A5 -5.14278
GALE UDP-galactose-4-epimerase -5.08863
ANKRD10 ankyrin repeat domain 10 -4.68762
SLC25A46 solute carrier family 25, member 46 -4.57235
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.45256
DERA deoxyribose-phosphate aldolase (putative) -4.33104
DNM1L dynamin 1-like -3.94323
HMG20B high mobility group 20B -3.85025
RPA3 replication protein A3, 14kDa -3.83826
CDK1 cyclin-dependent kinase 1 -3.77369
CRTAP cartilage associated protein -3.72369
LDHD lactate dehydrogenase D -3.62692
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.61837
MRPS16 mitochondrial ribosomal protein S16 -3.55263
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.41547
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.3889
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.38067
SCYL3 SCY1-like 3 (S. cerevisiae) -3.31829
SESN1 sestrin 1 -3.30107
COG4 component of oligomeric golgi complex 4 -3.30081
NUSAP1 nucleolar and spindle associated protein 1 -3.24627
PGM1 phosphoglucomutase 1 -3.22666
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.20763
UBE2C ubiquitin-conjugating enzyme E2C -3.14027
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -3.0933
HADH hydroxyacyl-CoA dehydrogenase -3.02474
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.96557
TXNDC9 thioredoxin domain containing 9 -2.96408
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.89925
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.86884
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.77884
CETN3 centrin, EF-hand protein, 3 -2.76957
OXCT1 3-oxoacid CoA transferase 1 -2.69112
NIT2 nitrilase family, member 2 -2.66275
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -2.65429
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.64311
EAPP E2F-associated phosphoprotein -2.64121
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.63497
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.62365
WASHC3 WASH complex subunit 3 -2.61463
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.57332
DDB2 damage-specific DNA binding protein 2, 48kDa -2.56875
THYN1 thymocyte nuclear protein 1 -2.567
MDH1 malate dehydrogenase 1, NAD (soluble) -2.54697
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.53655
HAUS4 HAUS augmin-like complex, subunit 4 -2.53394
KRCC1 lysine-rich coiled-coil 1 -2.51783
SUOX sulfite oxidase -2.51199
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -2.50062
STMN1 stathmin 1 -2.49536
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.48691
OXLD1 oxidoreductase-like domain containing 1 -2.45767
C1QBP complement component 1, q subcomponent binding protein -2.44406
CIRBP cold inducible RNA binding protein -2.4422
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.43932
CRYL1 crystallin, lambda 1 -2.43926
FKBP3 FK506 binding protein 3, 25kDa -2.43417
ZMYM2 zinc finger, MYM-type 2 -2.43025
SPAG7 sperm associated antigen 7 -2.41937
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -2.41519
RPL39L ribosomal protein L39-like -2.41453
BBS10 Bardet-Biedl syndrome 10 -2.37812
COG2 component of oligomeric golgi complex 2 -2.37781
METTL18 methyltransferase like 18 -2.3759
LETMD1 LETM1 domain containing 1 -2.3736
COQ6 coenzyme Q6 monooxygenase -2.3552
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.34725
COXFA4 cytochrome c oxidase associated subunit FA4 -2.34376
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.33703
ZFAND1 zinc finger, AN1-type domain 1 -2.33005
APOO apolipoprotein O -2.32116
CDC25B cell division cycle 25B -2.3157
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.3131
EXOC1 exocyst complex component 1 -2.30597
KLHDC2 kelch domain containing 2 -2.30498
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.29789
ITGA7 integrin, alpha 7 -2.29501
SNRPG small nuclear ribonucleoprotein polypeptide G -2.29457
R3HDM2 R3H domain containing 2 -2.28262
CKAP2 cytoskeleton associated protein 2 -2.27586
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.27487
COX5B cytochrome c oxidase subunit Vb -2.26182
CCDC90B coiled-coil domain containing 90B -2.26072
PSRC1 proline/serine-rich coiled-coil 1 -2.25526
MCTS1 malignant T cell amplified sequence 1 -2.21507
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.20738
OCEL1 occludin/ELL domain containing 1 -2.20427
NIPSNAP2 nipsnap homolog 2 -2.1987
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.19285
TMEM168 transmembrane protein 168 -2.1886
NISCH nischarin -2.18745
CCNB2 cyclin B2 -2.18262
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.18197
MSRB1 methionine sulfoxide reductase B1 -2.17277
PRPF39 pre-mRNA processing factor 39 -2.16714
NUP37 nucleoporin 37kDa -2.16423
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.1627
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.15628
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.15325
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.15278
MRPS14 mitochondrial ribosomal protein S14 -2.1524
ATP5PF ATP synthase peripheral stalk subunit F6 -2.1503
NNT nicotinamide nucleotide transhydrogenase -2.14776
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.14587
RWDD2A RWD domain containing 2A -2.14541
BOLA1 bolA family member 1 -2.14465
ADI1 acireductone dioxygenase 1 -2.14245
MED21 mediator complex subunit 21 -2.13818
ZNF518A zinc finger protein 518A -2.13508
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.13021
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.11241
S100B S100 calcium binding protein B -2.11202
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.10128
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -2.08781
RNF146 ring finger protein 146 -2.08472
ZDHHC6 zinc finger, DHHC-type containing 6 -2.08435
DENND2D DENN/MADD domain containing 2D -2.08406
BET1 Bet1 golgi vesicular membrane trafficking protein -2.08221
TRAF5 TNF receptor-associated factor 5 -2.07981
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -2.07886
CS citrate synthase -2.07536
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.07476
COX7B cytochrome c oxidase subunit VIIb -2.07415
UNC50 unc-50 homolog (C. elegans) -2.07194
DET1 de-etiolated homolog 1 (Arabidopsis) -2.06837
POT1 protection of telomeres 1 -2.06782
TP53 tumor protein p53 -2.06692
COPZ1 coatomer protein complex, subunit zeta 1 -2.06665
ZNF189 zinc finger protein 189 -2.06154
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.04547
ATRAID all-trans retinoic acid-induced differentiation factor -2.04393
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.03882
COMMD10 COMM domain containing 10 -2.03834
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.03395
ERI2 ERI1 exoribonuclease family member 2 -2.03246
TOP2A topoisomerase (DNA) II alpha 170kDa -2.03214
PILRB paired immunoglobin-like type 2 receptor beta -2.02745
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.0249
DDIT4 DNA-damage-inducible transcript 4 -2.02155
DPP8 dipeptidyl-peptidase 8 -2.01053
TBC1D3G TBC1 domain family member 3G -2.00975
CD58 CD58 molecule -2.00187
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.00119
RCOR3 REST corepressor 3 -2.0004