CRCGN017_MCF10A.TP53.M_24H:N12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description griseofulvin 11.17 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 4.60367
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.55571
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.74878
TLCD3A TLC domain containing 3A 3.68004
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.08222
IGHMBP2 immunoglobulin mu binding protein 2 2.93082
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.63661
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.49549
GPATCH8 G patch domain containing 8 2.48231
HBA1 hemoglobin, alpha 1 2.42356
TRAPPC4 trafficking protein particle complex 4 2.28288
CHN1 chimerin 1 2.16719
LYN LYN proto-oncogene, Src family tyrosine kinase 2.15915
MELK maternal embryonic leucine zipper kinase 2.14023
NRBF2 nuclear receptor binding factor 2 2.0976
EVL Enah/Vasp-like 2.0239
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.00473

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -4.689
GDF15 growth differentiation factor 15 -4.08421
HMG20B high mobility group 20B -3.99466
CYCS cytochrome c, somatic -3.94941
ADI1 acireductone dioxygenase 1 -3.79836
GALE UDP-galactose-4-epimerase -3.02406
TICAM1 toll-like receptor adaptor molecule 1 -2.92759
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.14897
DERA deoxyribose-phosphate aldolase (putative) -2.08475
IL4R interleukin 4 receptor -2.00558