CRCGN017_MCF10A.TP53.M_24H:N17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mitomycin c 32.87 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

710 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 9.89929
TICAM1 toll-like receptor adaptor molecule 1 8.88678
CNRIP1 cannabinoid receptor interacting protein 1 6.6676
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.06438
LAGE3 L antigen family, member 3 4.73644
CHIC2 cysteine-rich hydrophobic domain 2 4.66784
TXLNA taxilin alpha 4.66224
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.65634
RGS2 regulator of G-protein signaling 2 4.55453
CCNE2 cyclin E2 4.33154
CEMIP2 cell migration inducing hyaluronidase 2 4.32735
TRIM45 tripartite motif containing 45 4.26244
TCEA2 transcription elongation factor A (SII), 2 4.23388
TP53BP2 tumor protein p53 binding protein 2 4.02597
HSPB11 heat shock protein family B (small), member 11 3.94123
MINDY1 MINDY lysine 48 deubiquitinase 1 3.9241
CCND3 cyclin D3 3.91296
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.86433
MICB MHC class I polypeptide-related sequence B 3.80894
SKIC2 SKI2 subunit of superkiller complex 3.77017
ISG15 ISG15 ubiquitin-like modifier 3.74119
TUBB6 tubulin, beta 6 class V 3.73891
IL1B interleukin 1, beta 3.73599
BRCA1 breast cancer 1, early onset 3.72098
MX1 MX dynamin-like GTPase 1 3.69236
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.68307
ICAM1 intercellular adhesion molecule 1 3.66969
MYL9 myosin, light chain 9, regulatory 3.47777
CXCL2 chemokine (C-X-C motif) ligand 2 3.47479
ZNF672 zinc finger protein 672 3.43349
HLA-B major histocompatibility complex, class I, B 3.42884
FHL2 four and a half LIM domains 2 3.42662
CHAF1A chromatin assembly factor 1, subunit A (p150) 3.41112
IRF9 interferon regulatory factor 9 3.3982
CDC45 cell division cycle 45 3.39768
IRF7 interferon regulatory factor 7 3.35761
RMC1 regulator of MON1-CCZ1 3.35444
HELLS helicase, lymphoid-specific 3.35394
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.35012
ALAS1 5'-aminolevulinate synthase 1 3.31951
MAPK7 mitogen-activated protein kinase 7 3.31126
SAMD9 sterile alpha motif domain containing 9 3.30815
MEA1 male-enhanced antigen 1 3.28645
TUFT1 tuftelin 1 3.25164
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.24511
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 3.23587
USB1 U6 snRNA biogenesis 1 3.20882
ATF3 activating transcription factor 3 3.14721
PRR13 proline rich 13 3.13185
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.10662
RIGI RNA sensor RIG-I 3.09585
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.08597
CSRNP2 cysteine-serine-rich nuclear protein 2 3.07364
NBEAL2 neurobeachin-like 2 3.06617
HMOX1 heme oxygenase 1 3.04413
TIMELESS timeless circadian clock 3.0323
RND1 Rho family GTPase 1 3.00929
DDB2 damage-specific DNA binding protein 2, 48kDa 3.00402
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.99044
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.98905
PMP22 peripheral myelin protein 22 2.98594
GMEB2 glucocorticoid modulatory element binding protein 2 2.95737
ABHD4 abhydrolase domain containing 4 2.94822
IGFBP3 insulin-like growth factor binding protein 3 2.93076
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.92574
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.90181
NAGK N-acetylglucosamine kinase 2.89936
TERF2IP telomeric repeat binding factor 2, interacting protein 2.89931
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.89537
GADD45B growth arrest and DNA-damage-inducible, beta 2.89251
PSMC3IP PSMC3 interacting protein 2.88729
LCAT lecithin-cholesterol acyltransferase 2.88324
STAT1 signal transducer and activator of transcription 1, 91kDa 2.88097
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.8663
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.85684
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.85622
ATF5 activating transcription factor 5 2.83289
ORC6 origin recognition complex, subunit 6 2.82579
GDI1 GDP dissociation inhibitor 1 2.8256
HYI hydroxypyruvate isomerase (putative) 2.8111
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.79793
CLDN4 claudin 4 2.79599
TBC1D31 TBC1 domain family, member 31 2.78439
FBXO46 F-box protein 46 2.77406
HLA-C major histocompatibility complex, class I, C 2.75951
NUP85 nucleoporin 85kDa 2.74953
LRP10 low density lipoprotein receptor-related protein 10 2.7478
E2F1 E2F transcription factor 1 2.74357
HLA-F major histocompatibility complex, class I, F 2.74262
FANCG Fanconi anemia, complementation group G 2.73222
ERCC3 excision repair cross-complementation group 3 2.72961
CDPF1 cysteine-rich, DPF motif domain containing 1 2.7215
LGMN legumain 2.7146
DSCC1 DNA replication and sister chromatid cohesion 1 2.70167
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.69577
TNIP1 TNFAIP3 interacting protein 1 2.68356
BTN2A1 butyrophilin, subfamily 2, member A1 2.6718
RAB4B RAB4B, member RAS oncogene family 2.67177
KEAP1 kelch-like ECH-associated protein 1 2.66531
MFAP2 microfibrillar-associated protein 2 2.65475
PLA2G15 phospholipase A2, group XV 2.65264
IL1A interleukin 1, alpha 2.65201
PARP12 poly (ADP-ribose) polymerase family, member 12 2.64589
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.64484
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.64404
IFI6 interferon, alpha-inducible protein 6 2.64012
IFI27 interferon, alpha-inducible protein 27 2.62826
STIL SCL/TAL1 interrupting locus 2.62698
RAP1GAP RAP1 GTPase activating protein 2.62587
KRT8 keratin 8, type II 2.60954
C2CD3 C2 calcium-dependent domain containing 3 2.60839
CDC25A cell division cycle 25A 2.60544
IRF3 interferon regulatory factor 3 2.59728
ZNF212 zinc finger protein 212 2.59561
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.59553
ACAA1 acetyl-CoA acyltransferase 1 2.59493
STAP2 signal transducing adaptor family member 2 2.58867
RRAGC Ras-related GTP binding C 2.58373
RAD54L RAD54-like (S. cerevisiae) 2.58142
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.5792
WBP1L WW domain binding protein 1-like 2.57841
SNTA1 syntrophin, alpha 1 2.57718
SLC35E3 solute carrier family 35, member E3 2.57043
ECM1 extracellular matrix protein 1 2.56939
CHD8 chromodomain helicase DNA binding protein 8 2.56787
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.55999
ICAM3 intercellular adhesion molecule 3 2.55816
NENF neudesin neurotrophic factor 2.5546
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.54806
E2F8 E2F transcription factor 8 2.54383
HLA-A major histocompatibility complex, class I, A 2.54125
BSDC1 BSD domain containing 1 2.54083
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.53978
C2CD2L C2CD2-like 2.53876
PLAAT3 phospholipase A and acyltransferase 3 2.52663
BLCAP bladder cancer associated protein 2.51962
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.50933
ASF1B anti-silencing function 1B histone chaperone 2.50559
MZT2A mitotic spindle organizing protein 2A 2.50014
CCNE1 cyclin E1 2.49471
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.493
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.4884
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.47802
AMOTL2 angiomotin like 2 2.47607
RAP1B RAP1B, member of RAS oncogene family 2.46609
ANXA4 annexin A4 2.45443
ITPKC inositol-trisphosphate 3-kinase C 2.45438
NDEL1 nudE neurodevelopment protein 1-like 1 2.4536
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.45206
CAVIN1 caveolae associated protein 1 2.45011
ELF4 E74-like factor 4 (ets domain transcription factor) 2.44474
YPEL1 yippee-like 1 (Drosophila) 2.44243
MAPK3 mitogen-activated protein kinase 3 2.43501
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.43288
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.43023
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.42155
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.41839
USP11 ubiquitin specific peptidase 11 2.41424
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 2.40757
TBC1D10B TBC1 domain family, member 10B 2.4073
EXO1 exonuclease 1 2.40487
ARMCX6 armadillo repeat containing, X-linked 6 2.39497
JOSD1 Josephin domain containing 1 2.38537
HOXC11 homeobox C11 2.38214
TMEM140 transmembrane protein 140 2.38095
CYB5R2 cytochrome b5 reductase 2 2.37908
TKTL1 transketolase-like 1 2.37642
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.37637
PEG10 paternally expressed 10 2.37535
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.37416
LARP6 La ribonucleoprotein domain family, member 6 2.37203
KIF3B kinesin family member 3B 2.36726
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.36407
EGF epidermal growth factor 2.36215
MYO1E myosin IE 2.35858
RFWD3 ring finger and WD repeat domain 3 2.35468
OCA2 oculocutaneous albinism II 2.34952
ENTREP1 endosomal transmembrane epsin interactor 1 2.34918
MTMR11 myotubularin related protein 11 2.34683
DUSP14 dual specificity phosphatase 14 2.34312
ZNF14 zinc finger protein 14 2.33934
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.33924
GATA2 GATA binding protein 2 2.33919
ZNF611 zinc finger protein 611 2.33714
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.33491
MISP mitotic spindle positioning 2.33072
ARHGAP29 Rho GTPase activating protein 29 2.33008
MUC1 mucin 1, cell surface associated 2.3282
CYB5RL cytochrome b5 reductase-like 2.3281
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 2.31718
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.31372
INTS3 integrator complex subunit 3 2.30989
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.30203
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.30134
FAM110B family with sequence similarity 110, member B 2.30001
MUC13 mucin 13, cell surface associated 2.29883
TMEM132A transmembrane protein 132A 2.29669
OASL 2'-5'-oligoadenylate synthetase-like 2.29582
SCD5 stearoyl-CoA desaturase 5 2.29391
IL22RA1 interleukin 22 receptor, alpha 1 2.29085
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.28729
USP1 ubiquitin specific peptidase 1 2.28473
SLC10A3 solute carrier family 10, member 3 2.27497
NECAP2 NECAP endocytosis associated 2 2.2744
GCC1 GRIP and coiled-coil domain containing 1 2.27356
TYK2 tyrosine kinase 2 2.26892
DSN1 DSN1, MIS12 kinetochore complex component 2.26512
ADM adrenomedullin 2.25982
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.25138
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.24906
EPHA2 EPH receptor A2 2.24495
EMX2 empty spiracles homeobox 2 2.2436
IFI35 interferon-induced protein 35 2.24344
NUAK2 NUAK family, SNF1-like kinase, 2 2.2433
TOR1AIP2 torsin A interacting protein 2 2.23882
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.2371
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.23418
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.23373
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.23203
ZNF136 zinc finger protein 136 2.23088
GNLY granulysin 2.22973
SHBG sex hormone-binding globulin 2.22768
ZBTB48 zinc finger and BTB domain containing 48 2.22141
CLTB clathrin, light chain B 2.21865
COL8A2 collagen, type VIII, alpha 2 2.21314
DDAH2 dimethylarginine dimethylaminohydrolase 2 2.20803
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.203
RNF25 ring finger protein 25 2.20074
CES3 carboxylesterase 3 2.19962
SAP25 Sin3A-associated protein, 25kDa 2.19748
KIAA0319L KIAA0319-like 2.19586
HMGXB4 HMG box domain containing 4 2.19578
CPA2 carboxypeptidase A2 (pancreatic) 2.19241
HAUS2 HAUS augmin-like complex, subunit 2 2.1867
CDIP1 cell death-inducing p53 target 1 2.18631
HPSE heparanase 2.18331
ADORA2A adenosine A2a receptor 2.18222
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.18176
TOR3A torsin family 3, member A 2.17972
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.17378
SPINK1 serine peptidase inhibitor, Kazal type 1 2.17363
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.17211
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.1699
CALCOCO1 calcium binding and coiled-coil domain 1 2.16989
TJP3 tight junction protein 3 2.15725
REC8 REC8 meiotic recombination protein 2.15643
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.15622
CHMP1A charged multivesicular body protein 1A 2.15526
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.15507
WDTC1 WD and tetratricopeptide repeats 1 2.14773
DERL2 derlin 2 2.14504
IRF1 interferon regulatory factor 1 2.13699
BARD1 BRCA1 associated RING domain 1 2.13656
LRRC42 leucine rich repeat containing 42 2.13433
ZGPAT zinc finger, CCCH-type with G patch domain 2.13368
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.13116
YIPF1 Yip1 domain family, member 1 2.13059
TP53I3 tumor protein p53 inducible protein 3 2.13058
EPHX3 epoxide hydrolase 3 2.12508
FMR1 fragile X mental retardation 1 2.12362
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.1199
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.11814
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.11772
CAPN1 calpain 1, (mu/I) large subunit 2.11769
GNL1 guanine nucleotide binding protein-like 1 2.1138
RLF rearranged L-myc fusion 2.10987
ANXA10 annexin A10 2.10868
ASB1 ankyrin repeat and SOCS box containing 1 2.10794
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.10643
RECQL4 RecQ protein-like 4 2.10636
LGALS1 lectin, galactoside-binding, soluble, 1 2.1007
MXRA5 matrix-remodelling associated 5 2.10042
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 2.09993
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.09985
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.09389
LSR lipolysis stimulated lipoprotein receptor 2.0906
CXADR coxsackie virus and adenovirus receptor 2.09031
TRIM21 tripartite motif containing 21 2.08732
BCL9 B-cell CLL/lymphoma 9 2.08665
IL12RB2 interleukin 12 receptor, beta 2 2.08406
CDC6 cell division cycle 6 2.08277
TMPRSS3 transmembrane protease, serine 3 2.08255
MCOLN1 mucolipin 1 2.08123
GUSB glucuronidase, beta 2.07989
SDC4 syndecan 4 2.07892
PPCDC phosphopantothenoylcysteine decarboxylase 2.07833
SAP30BP SAP30 binding protein 2.07732
RECQL RecQ helicase-like 2.07573
UPK3B uroplakin 3B 2.07513
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.07302
CARD8 caspase recruitment domain family, member 8 2.06605
UBE2A ubiquitin-conjugating enzyme E2A 2.06319
FAM50A family with sequence similarity 50, member A 2.05912
CMTR1 cap methyltransferase 1 2.05495
HOXC10 homeobox C10 2.0548
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.05248
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.0521
TMCC2 transmembrane and coiled-coil domain family 2 2.05169
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 2.05004
CTRC chymotrypsin C (caldecrin) 2.04927
SLC16A6 solute carrier family 16, member 6 2.04771
ZNF324 zinc finger protein 324 2.04584
PAOX polyamine oxidase (exo-N4-amino) 2.04523
AAMP angio-associated, migratory cell protein 2.04505
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.04344
AGR2 anterior gradient 2 2.0423
LGALS9C lectin, galactoside-binding, soluble, 9C 2.03986
TBX21 T-box 21 2.03913
SYT17 synaptotagmin XVII 2.03895
FAM174B family with sequence similarity 174, member B 2.03734
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.0366
PRR15L proline rich 15-like 2.03639
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.03359
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.03316
ACTMAP actin maturation protease 2.03258
RBL1 retinoblastoma-like 1 2.03242
SPAG1 sperm associated antigen 1 2.03194
FAM32A family with sequence similarity 32, member A 2.0315
INAVA innate immunity activator 2.03147
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.02826
OSR2 odd-skipped related transciption factor 2 2.02577
IL6 interleukin 6 2.02562
TIMP2 TIMP metallopeptidase inhibitor 2 2.02393
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.02384
CANT1 calcium activated nucleotidase 1 2.02105
TNF tumor necrosis factor 2.01964
TMEM40 transmembrane protein 40 2.01826
IL11RA interleukin 11 receptor, alpha 2.01724
ZDHHC13 zinc finger, DHHC-type containing 13 2.01666
INKA2 inka box actin regulator 2 2.01521
CTRB2 chymotrypsinogen B2 2.01503
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.01326
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.01282
PPCS phosphopantothenoylcysteine synthetase 2.01203
USP18 ubiquitin specific peptidase 18 2.01052
MOXD1 monooxygenase, DBH-like 1 2.00803
FSTL1 follistatin-like 1 2.00687
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit 2.00664
SGPP2 sphingosine-1-phosphate phosphatase 2 2.00633
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 2.00476
BRME1 break repair meiotic recombinase recruitment factor 1 2.00461
NPC1 Niemann-Pick disease, type C1 2.00277
S100PBP S100P binding protein 2.00263
CEP131 centrosomal protein 131kDa 2.00224
TTI1 TELO2 interacting protein 1 2.00211
RSAD2 radical S-adenosyl methionine domain containing 2 2.00157
NRG1 neuregulin 1 2.00128
KDM6B lysine (K)-specific demethylase 6B 2.00122
ARID5A AT rich interactive domain 5A (MRF1-like) 2.00058

decreased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 -9.7686
HSPA8 heat shock 70kDa protein 8 -7.03948
MSRA methionine sulfoxide reductase A -6.76619
PSRC1 proline/serine-rich coiled-coil 1 -6.76518
MRPL12 mitochondrial ribosomal protein L12 -6.04251
ASCC3 activating signal cointegrator 1 complex subunit 3 -5.68427
CDC20 cell division cycle 20 -5.35545
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.35318
KIF20A kinesin family member 20A -5.32506
CCNB2 cyclin B2 -5.00803
CCNB1 cyclin B1 -4.6972
BZW2 basic leucine zipper and W2 domains 2 -4.6538
PLK1 polo-like kinase 1 -4.47487
LBR lamin B receptor -4.33472
TOP2A topoisomerase (DNA) II alpha 170kDa -4.18741
ANO10 anoctamin 10 -4.1819
GPHN gephyrin -4.15
C1QBP complement component 1, q subcomponent binding protein -4.12494
MRPL3 mitochondrial ribosomal protein L3 -4.1171
EPHB2 EPH receptor B2 -4.062
ELP4 elongator acetyltransferase complex subunit 4 -4.00457
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.99401
AURKA aurora kinase A -3.88736
HSPA1A heat shock 70kDa protein 1A -3.76886
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.76836
AXIN1 axin 1 -3.74575
ANXA2 annexin A2 -3.71479
HDAC2 histone deacetylase 2 -3.71419
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.66071
SLC35F2 solute carrier family 35, member F2 -3.57621
TRAP1 TNF receptor-associated protein 1 -3.55182
COQ3 coenzyme Q3 methyltransferase -3.52999
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -3.52961
PPA1 pyrophosphatase (inorganic) 1 -3.51701
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -3.40186
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.38867
CLNS1A chloride channel, nucleotide-sensitive, 1A -3.37693
MRPL19 mitochondrial ribosomal protein L19 -3.37348
CCT4 chaperonin containing TCP1, subunit 4 (delta) -3.35756
C2CD2 C2 calcium-dependent domain containing 2 -3.33564
ANKRD10 ankyrin repeat domain 10 -3.33509
PGM1 phosphoglucomutase 1 -3.32191
ALG3 ALG3, alpha-1,3- mannosyltransferase -3.31845
BLMH bleomycin hydrolase -3.31672
MEMO1 mediator of cell motility 1 -3.29049
PPARG peroxisome proliferator-activated receptor gamma -3.27126
TCTA T-cell leukemia translocation altered -3.25758
TAC4 tachykinin 4 (hemokinin) -3.23788
MNAT1 MNAT CDK-activating kinase assembly factor 1 -3.22768
BAG3 BCL2-associated athanogene 3 -3.20111
BASP1 brain abundant, membrane attached signal protein 1 -3.17633
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -3.1482
DET1 de-etiolated homolog 1 (Arabidopsis) -3.1191
MRPL58 mitochondrial ribosomal protein L58 -3.11522
CYCS cytochrome c, somatic -3.09483
MRPS22 mitochondrial ribosomal protein S22 -3.08684
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -3.08543
PCDHB16 protocadherin beta 16 -3.0657
HSPD1 heat shock 60kDa protein 1 (chaperonin) -3.06359
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -3.05873
EIF3E eukaryotic translation initiation factor 3, subunit E -3.04662
SCARB1 scavenger receptor class B, member 1 -3.04183
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.01743
CCNA2 cyclin A2 -3.01322
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -3.00926
RBMX RNA binding motif protein, X-linked -3.00731
MTIF2 mitochondrial translational initiation factor 2 -3.00302
TSPAN4 tetraspanin 4 -2.99788
APEH acylaminoacyl-peptide hydrolase -2.99685
GIN1 gypsy retrotransposon integrase 1 -2.99392
RPIA ribose 5-phosphate isomerase A -2.98418
TULP4 tubby like protein 4 -2.98394
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.98021
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.9771
COMMD10 COMM domain containing 10 -2.97678
NUP37 nucleoporin 37kDa -2.97362
ARB2A ARB2 cotranscriptional regulator A -2.96469
CENPA centromere protein A -2.94604
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.94503
RHOT1 ras homolog family member T1 -2.91464
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.89922
CEP63 centrosomal protein 63kDa -2.89841
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.88816
USP21 ubiquitin specific peptidase 21 -2.88459
UFSP2 UFM1-specific peptidase 2 -2.88292
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.88103
FKBP5 FK506 binding protein 5 -2.86993
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.86318
DCTD dCMP deaminase -2.84713
MRPS7 mitochondrial ribosomal protein S7 -2.83821
PCCB propionyl CoA carboxylase, beta polypeptide -2.81402
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 -2.81337
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.80449
TSKU tsukushi, small leucine rich proteoglycan -2.7985
BIRC5 baculoviral IAP repeat containing 5 -2.79513
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.78193
NPR2 natriuretic peptide receptor 2 -2.78043
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.7787
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.76143
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.76049
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -2.7555
TRMT61B tRNA methyltransferase 61B -2.7543
KIAA0586 KIAA0586 -2.74731
NCAPD2 non-SMC condensin I complex, subunit D2 -2.74173
PYCR1 pyrroline-5-carboxylate reductase 1 -2.74039
CDCA3 cell division cycle associated 3 -2.73863
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.736
TMEM100 transmembrane protein 100 -2.72942
MKRN2 makorin ring finger protein 2 -2.72231
TBC1D16 TBC1 domain family, member 16 -2.71881
ITGA6 integrin, alpha 6 -2.71152
UBE2C ubiquitin-conjugating enzyme E2C -2.7079
TXNRD3 thioredoxin reductase 3 -2.69882
ASF1A anti-silencing function 1A histone chaperone -2.6934
PRMT3 protein arginine methyltransferase 3 -2.68395
NIPSNAP2 nipsnap homolog 2 -2.68392
PIBF1 progesterone immunomodulatory binding factor 1 -2.67439
COL4A2 collagen, type IV, alpha 2 -2.67338
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.66702
TOMM70 translocase of outer mitochondrial membrane 70 -2.66463
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.65818
TSC22D3 TSC22 domain family, member 3 -2.6548
NCK2 NCK adaptor protein 2 -2.65241
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -2.63606
GPSM2 G-protein signaling modulator 2 -2.6349
LDHA lactate dehydrogenase A -2.6163
SKIC3 SKI3 subunit of superkiller complex -2.61312
H2BC12 H2B clustered histone 12 -2.61062
PHKB phosphorylase kinase, beta -2.6027
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.59857
UBE3C ubiquitin protein ligase E3C -2.59584
ENTR1 endosome associated trafficking regulator 1 -2.5905
SESN1 sestrin 1 -2.5905
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.58804
RSU1 Ras suppressor protein 1 -2.57058
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.56976
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.56809
FHIT fragile histidine triad -2.56717
PTK2 protein tyrosine kinase 2 -2.56567
SCRG1 stimulator of chondrogenesis 1 -2.56431
SMYD2 SET and MYND domain containing 2 -2.56123
TFB1M transcription factor B1, mitochondrial -2.55568
LIAS lipoic acid synthetase -2.555
PARVB parvin, beta -2.55154
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.54909
KIF14 kinesin family member 14 -2.54333
SPRY2 sprouty homolog 2 (Drosophila) -2.54298
THOC7 THO complex 7 -2.53758
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.5307
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.52946
RBL2 retinoblastoma-like 2 -2.52497
FER fer (fps/fes related) tyrosine kinase -2.52365
GYG1 glycogenin 1 -2.5176
CETN3 centrin, EF-hand protein, 3 -2.51535
RIOX2 ribosomal oxygenase 2 -2.50987
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.50423
RYK receptor-like tyrosine kinase -2.5042
PUS1 pseudouridylate synthase 1 -2.50301
ATP5F1A ATP synthase F1 subunit alpha -2.49701
APIP APAF1 interacting protein -2.49138
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -2.48822
CRTAP cartilage associated protein -2.48807
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.48762
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.48745
MRPL42 mitochondrial ribosomal protein L42 -2.48532
MPZL1 myelin protein zero-like 1 -2.48276
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.48136
GSPT1 G1 to S phase transition 1 -2.47799
PCDHB11 protocadherin beta 11 -2.46697
TKT transketolase -2.46262
MCTS1 malignant T cell amplified sequence 1 -2.46063
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.45995
NMD3 NMD3 ribosome export adaptor -2.45408
TFB2M transcription factor B2, mitochondrial -2.45302
TBC1D4 TBC1 domain family, member 4 -2.44141
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.43805
RAD50 RAD50 homolog (S. cerevisiae) -2.43513
URI1 URI1, prefoldin-like chaperone -2.43488
WASF3 WAS protein family, member 3 -2.43321
IARS1 isoleucyl-tRNA synthetase 1 -2.43285
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.42967
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.42857
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -2.42744
PPA2 pyrophosphatase (inorganic) 2 -2.42648
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.40658
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -2.39797
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -2.39519
CDKN3 cyclin-dependent kinase inhibitor 3 -2.39516
MLH3 mutL homolog 3 -2.3911
CDK8 cyclin-dependent kinase 8 -2.38935
SNX17 sorting nexin 17 -2.38381
NHP2 NHP2 ribonucleoprotein -2.38313
H2BC9 H2B clustered histone 9 -2.38301
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.37022
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.36476
ANXA7 annexin A7 -2.36322
MTREX Mtr4 exosome RNA helicase -2.35957
PCBP1 poly(rC) binding protein 1 -2.35863
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.35129
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -2.34635
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.34353
ANKRD17 ankyrin repeat domain 17 -2.3411
TTC27 tetratricopeptide repeat domain 27 -2.33773
CAMKMT calmodulin-lysine N-methyltransferase -2.3344
NOP16 NOP16 nucleolar protein -2.33435
NECTIN4 nectin cell adhesion molecule 4 -2.33187
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.32865
PBK PDZ binding kinase -2.32612
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.32437
ALG9 ALG9, alpha-1,2-mannosyltransferase -2.32343
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.31769
ZMIZ1 zinc finger, MIZ-type containing 1 -2.3175
LRPPRC leucine-rich pentatricopeptide repeat containing -2.31542
CADPS2 Ca++-dependent secretion activator 2 -2.31512
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.31305
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.31229
SRPRB signal recognition particle receptor, B subunit -2.3064
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -2.30338
DERA deoxyribose-phosphate aldolase (putative) -2.30327
WDR12 WD repeat domain 12 -2.30274
RPP40 ribonuclease P/MRP 40kDa subunit -2.30232
TARP TCR gamma alternate reading frame protein -2.29858
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.29607
KARS1 lysyl-tRNA synthetase 1 -2.2909
EBNA1BP2 EBNA1 binding protein 2 -2.29048
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.28723
PEX2 peroxisomal biogenesis factor 2 -2.28563
SOCS5 suppressor of cytokine signaling 5 -2.28277
ACY1 aminoacylase 1 -2.28179
FKTN fukutin -2.27901
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.27455
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.27351
HMGN4 high mobility group nucleosomal binding domain 4 -2.27061
AQP5 aquaporin 5 -2.26136
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.25897
ATP5F1C ATP synthase F1 subunit gamma -2.25677
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.24828
KIFBP kinesin family binding protein -2.23871
SOBP sine oculis binding protein homolog (Drosophila) -2.23634
NBAS neuroblastoma amplified sequence -2.23071
NLRP2B NLR family pyrin domain containing 2B -2.23044
SLC41A3 solute carrier family 41, member 3 -2.22829
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.22564
SNX2 sorting nexin 2 -2.22156
UTP11 UTP11 small subunit processome component -2.21698
DLAT dihydrolipoamide S-acetyltransferase -2.21681
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.21599
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.20931
MTFR1 mitochondrial fission regulator 1 -2.20895
ENO1 enolase 1, (alpha) -2.20716
FBXL4 F-box and leucine-rich repeat protein 4 -2.20475
MPHOSPH6 M-phase phosphoprotein 6 -2.19913
EXOC2 exocyst complex component 2 -2.19174
IPO7 importin 7 -2.18715
SRP72 signal recognition particle 72kDa -2.18509
SMAP1 small ArfGAP 1 -2.18352
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.18152
SLC38A6 solute carrier family 38, member 6 -2.18148
DBF4 DBF4 zinc finger -2.17801
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.17614
HSDL2 hydroxysteroid dehydrogenase like 2 -2.17498
PGK1 phosphoglycerate kinase 1 -2.17429
RUVBL1 RuvB-like AAA ATPase 1 -2.17122
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -2.16942
GALE UDP-galactose-4-epimerase -2.16788
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.16781
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.16701
LDAH lipid droplet associated hydrolase -2.16471
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -2.16408
COL4A1 collagen, type IV, alpha 1 -2.1632
CD320 CD320 molecule -2.16267
MRPS33 mitochondrial ribosomal protein S33 -2.16262
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.16145
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.15651
MRPS18B mitochondrial ribosomal protein S18B -2.15379
DEPDC1 DEP domain containing 1 -2.15195
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.1514
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.15
PCCA propionyl CoA carboxylase, alpha polypeptide -2.14773
ERAP2 endoplasmic reticulum aminopeptidase 2 -2.14741
SPA17 sperm autoantigenic protein 17 -2.14535
PTTG1 pituitary tumor-transforming 1 -2.14122
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -2.13936
IRX5 iroquois homeobox 5 -2.13891
CUL1 cullin 1 -2.1384
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.13712
ANAPC10 anaphase promoting complex subunit 10 -2.1348
ATP5F1B ATP synthase F1 subunit beta -2.13389
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.12966
ANAPC1 anaphase promoting complex subunit 1 -2.12927
SEC63 SEC63 homolog (S. cerevisiae) -2.12856
TBC1D5 TBC1 domain family, member 5 -2.12712
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.12454
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.12168
KIF4A kinesin family member 4A -2.11823
CKAP2 cytoskeleton associated protein 2 -2.11713
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.1157
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.11449
COPZ1 coatomer protein complex, subunit zeta 1 -2.11421
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.11093
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -2.11043
KDM1A lysine (K)-specific demethylase 1A -2.10914
NEK2 NIMA-related kinase 2 -2.10188
INSIG1 insulin induced gene 1 -2.0998
TTK TTK protein kinase -2.09627
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.09013
COL2A1 collagen, type II, alpha 1 -2.08691
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -2.08179
GCLC glutamate-cysteine ligase, catalytic subunit -2.07903
CLOCK clock circadian regulator -2.07902
FLOT2 flotillin 2 -2.07813
ALPL alkaline phosphatase, liver/bone/kidney -2.07661
MUC7 mucin 7, secreted -2.0763
EIPR1 EARP complex and GARP complex interacting protein 1 -2.07305
TMEM43 transmembrane protein 43 -2.06917
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.06779
PDCD2 programmed cell death 2 -2.06714
APRT adenine phosphoribosyltransferase -2.06587
INTS14 integrator complex subunit 14 -2.06499
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.06407
ADGRA3 adhesion G protein-coupled receptor A3 -2.06389
MACROH2A2 macroH2A.2 histone -2.06306
ILF2 interleukin enhancer binding factor 2 -2.06252
AGPS alkylglycerone phosphate synthase -2.06241
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.06034
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.05865
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.05759
CHRDL1 chordin-like 1 -2.05693
UGP2 UDP-glucose pyrophosphorylase 2 -2.05562
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.05374
SUMF2 sulfatase modifying factor 2 -2.05188
COPS5 COP9 signalosome subunit 5 -2.05036
CSNK1G3 casein kinase 1, gamma 3 -2.04812
C1GALT1C1 C1GALT1-specific chaperone 1 -2.04474
PMPCA peptidase (mitochondrial processing) alpha -2.04288
RAN RAN, member RAS oncogene family -2.04177
ZMYM1 zinc finger, MYM-type 1 -2.04143
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.04109
SRBD1 S1 RNA binding domain 1 -2.03896
HOMER2 homer scaffolding protein 2 -2.03788
VSIG4 V-set and immunoglobulin domain containing 4 -2.03426
BACE2 beta-site APP-cleaving enzyme 2 -2.03409
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.03238
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -2.02993
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.02833
KCTD5 potassium channel tetramerization domain containing 5 -2.01967
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.01901
WDR74 WD repeat domain 74 -2.01868
RABEPK Rab9 effector protein with kelch motifs -2.01682
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.01589
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -2.01427
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) -2.01305
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.01031
HNRNPR heterogeneous nuclear ribonucleoprotein R -2.00774
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.00539
PUM2 pumilio RNA-binding family member 2 -2.00444
CIRBP cold inducible RNA binding protein -2.00362
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.00325
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.00131
NUP93 nucleoporin 93kDa -2.00067
SLC25A46 solute carrier family 25, member 46 -2.00024