| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | mitomycin c 10.96 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
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216 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 7.28896 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 5.18555 |
| MYL9 | myosin, light chain 9, regulatory | 4.85383 |
| TCEA2 | transcription elongation factor A (SII), 2 | 4.26883 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 4.18231 |
| CDC45 | cell division cycle 45 | 3.31486 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 3.1237 |
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 3.11311 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 3.08504 |
| CCND3 | cyclin D3 | 2.98186 |
| CCNE2 | cyclin E2 | 2.96727 |
| BRCA1 | breast cancer 1, early onset | 2.95508 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 2.93836 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.83981 |
| CAPN1 | calpain 1, (mu/I) large subunit | 2.83424 |
| TRIM45 | tripartite motif containing 45 | 2.83229 |
| TUBB6 | tubulin, beta 6 class V | 2.79116 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 2.75592 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 | 2.74317 |
| MCM5 | minichromosome maintenance complex component 5 | 2.72208 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 2.698 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 2.68419 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 2.64286 |
| MX1 | MX dynamin-like GTPase 1 | 2.61201 |
| STAP2 | signal transducing adaptor family member 2 | 2.60767 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.59331 |
| EPS8L2 | EPS8-like 2 | 2.59055 |
| MFAP5 | microfibrillar associated protein 5 | 2.56847 |
| TP53I3 | tumor protein p53 inducible protein 3 | 2.54948 |
| FANCG | Fanconi anemia, complementation group G | 2.50442 |
| MFAP2 | microfibrillar-associated protein 2 | 2.47441 |
| E2F1 | E2F transcription factor 1 | 2.43279 |
| APOL2 | apolipoprotein L, 2 | 2.43013 |
| TRIM21 | tripartite motif containing 21 | 2.40941 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 2.39324 |
| MUC1 | mucin 1, cell surface associated | 2.38453 |
| SAMD9 | sterile alpha motif domain containing 9 | 2.37161 |
| POLE | polymerase (DNA directed), epsilon, catalytic subunit | 2.35717 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.34836 |
| TCN2 | transcobalamin II | 2.3414 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.33144 |
| PSMC3IP | PSMC3 interacting protein | 2.33049 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.32946 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 2.30897 |
| RIGI | RNA sensor RIG-I | 2.29504 |
| ISG15 | ISG15 ubiquitin-like modifier | 2.26564 |
| ICAM3 | intercellular adhesion molecule 3 | 2.25879 |
| ASPN | asporin | 2.25597 |
| KNTC1 | kinetochore associated 1 | 2.25529 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 2.25283 |
| TUFT1 | tuftelin 1 | 2.2484 |
| IL1B | interleukin 1, beta | 2.24115 |
| THBS2 | thrombospondin 2 | 2.23032 |
| SMPD4 | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) | 2.22659 |
| LGALS9C | lectin, galactoside-binding, soluble, 9C | 2.22119 |
| APH1A | APH1A gamma secretase subunit | 2.21865 |
| HLA-B | major histocompatibility complex, class I, B | 2.21066 |
| CYB5R1 | cytochrome b5 reductase 1 | 2.20447 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.19366 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 2.18314 |
| LMF2 | lipase maturation factor 2 | 2.16762 |
| PMP22 | peripheral myelin protein 22 | 2.15542 |
| ILKAP | integrin-linked kinase-associated serine/threonine phosphatase | 2.15506 |
| CLTB | clathrin, light chain B | 2.15303 |
| OSTF1 | osteoclast stimulating factor 1 | 2.14891 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 2.14809 |
| PPP1R17 | protein phosphatase 1, regulatory subunit 17 | 2.14426 |
| PARD6A | par-6 family cell polarity regulator alpha | 2.14413 |
| CYB5R3 | cytochrome b5 reductase 3 | 2.14329 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 2.14171 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.13821 |
| IRF9 | interferon regulatory factor 9 | 2.13387 |
| IFI6 | interferon, alpha-inducible protein 6 | 2.13359 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.12895 |
| CNN1 | calponin 1, basic, smooth muscle | 2.12833 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | 2.1175 |
| SMIM5 | small integral membrane protein 5 | 2.11479 |
| CUEDC1 | CUE domain containing 1 | 2.11311 |
| TSPAN1 | tetraspanin 1 | 2.11263 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | 2.1119 |
| RFC4 | replication factor C (activator 1) 4, 37kDa | 2.10124 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 2.10005 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | 2.09219 |
| KRT23 | keratin 23, type I | 2.08758 |
| IFI27 | interferon, alpha-inducible protein 27 | 2.0866 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | 2.0749 |
| CCNE1 | cyclin E1 | 2.07436 |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 2.07206 |
| NBEAL2 | neurobeachin-like 2 | 2.07158 |
| APOL1 | apolipoprotein L, 1 | 2.06889 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 2.0585 |
| MPC2 | mitochondrial pyruvate carrier 2 | 2.05523 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 2.05099 |
| PLSCR1 | phospholipid scramblase 1 | 2.04996 |
| CYB5R2 | cytochrome b5 reductase 2 | 2.04367 |
| WDR76 | WD repeat domain 76 | 2.03879 |
| ZNF136 | zinc finger protein 136 | 2.03504 |
| TP53BP2 | tumor protein p53 binding protein 2 | 2.02351 |
| HELLS | helicase, lymphoid-specific | 2.0146 |
| JOSD1 | Josephin domain containing 1 | 2.01374 |
| CES3 | carboxylesterase 3 | 2.00818 |
| ECM1 | extracellular matrix protein 1 | 2.00688 |
| CDIP1 | cell death-inducing p53 target 1 | 2.00494 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 2.00097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KIF20A | kinesin family member 20A | -7.70954 |
| CDC20 | cell division cycle 20 | -6.04936 |
| CCNB2 | cyclin B2 | -5.74541 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -5.34963 |
| DDIT4 | DNA-damage-inducible transcript 4 | -5.24835 |
| PLK1 | polo-like kinase 1 | -4.68147 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.53034 |
| LBR | lamin B receptor | -4.164 |
| KIF14 | kinesin family member 14 | -4.0331 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.88791 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -3.84134 |
| TEX10 | testis expressed 10 | -3.72014 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -3.68799 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -3.63961 |
| HDAC2 | histone deacetylase 2 | -3.61704 |
| MRPL12 | mitochondrial ribosomal protein L12 | -3.56204 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -3.55969 |
| HSPA8 | heat shock 70kDa protein 8 | -3.29803 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -3.28366 |
| DEPDC1 | DEP domain containing 1 | -3.20705 |
| BAG3 | BCL2-associated athanogene 3 | -3.17343 |
| DET1 | de-etiolated homolog 1 (Arabidopsis) | -3.11641 |
| CHMP4B | charged multivesicular body protein 4B | -3.11274 |
| AURKA | aurora kinase A | -3.09014 |
| CCNB1 | cyclin B1 | -3.07694 |
| CENPA | centromere protein A | -3.03326 |
| THAP11 | THAP domain containing 11 | -3.02488 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -3.02017 |
| H2BC12 | H2B clustered histone 12 | -3.00443 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.98733 |
| CDCA3 | cell division cycle associated 3 | -2.94327 |
| HSPA1A | heat shock 70kDa protein 1A | -2.90445 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | -2.88063 |
| NCK2 | NCK adaptor protein 2 | -2.77836 |
| CCNA2 | cyclin A2 | -2.75422 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -2.74573 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.67589 |
| MRTFB | myocardin related transcription factor B | -2.64556 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.63062 |
| KIF4A | kinesin family member 4A | -2.6206 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.60456 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.57873 |
| CDC25C | cell division cycle 25C | -2.56897 |
| KIAA0586 | KIAA0586 | -2.54937 |
| CDC25B | cell division cycle 25B | -2.5358 |
| HDAC3 | histone deacetylase 3 | -2.53486 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.5259 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -2.45556 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -2.42393 |
| HEATR1 | HEAT repeat containing 1 | -2.42078 |
| EBNA1BP2 | EBNA1 binding protein 2 | -2.41595 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -2.41575 |
| CKAP2 | cytoskeleton associated protein 2 | -2.41332 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.4097 |
| MRPL58 | mitochondrial ribosomal protein L58 | -2.40831 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -2.39691 |
| PTTG1 | pituitary tumor-transforming 1 | -2.36709 |
| SEC23IP | SEC23 interacting protein | -2.35332 |
| PARK7 | parkinson protein 7 | -2.34953 |
| ENO1 | enolase 1, (alpha) | -2.34435 |
| PCDHB16 | protocadherin beta 16 | -2.3441 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | -2.32294 |
| NEK2 | NIMA-related kinase 2 | -2.30546 |
| C1QBP | complement component 1, q subcomponent binding protein | -2.29415 |
| RHOT1 | ras homolog family member T1 | -2.27801 |
| TAC4 | tachykinin 4 (hemokinin) | -2.27402 |
| TPX2 | TPX2, microtubule-associated | -2.26873 |
| TSKU | tsukushi, small leucine rich proteoglycan | -2.26728 |
| KIF23 | kinesin family member 23 | -2.26637 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -2.25354 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -2.24081 |
| CCR7 | chemokine (C-C motif) receptor 7 | -2.23419 |
| NCBP2 | nuclear cap binding protein subunit 2, 20kDa | -2.23344 |
| CTSL | cathepsin L | -2.22954 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -2.2127 |
| TTK | TTK protein kinase | -2.21158 |
| TOMM70 | translocase of outer mitochondrial membrane 70 | -2.20442 |
| GIN1 | gypsy retrotransposon integrase 1 | -2.2012 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -2.19536 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.19156 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -2.18672 |
| SLC35F2 | solute carrier family 35, member F2 | -2.18652 |
| GSPT1 | G1 to S phase transition 1 | -2.17081 |
| ZBTB24 | zinc finger and BTB domain containing 24 | -2.16002 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -2.15677 |
| ZNF146 | zinc finger protein 146 | -2.15028 |
| CCNG1 | cyclin G1 | -2.13576 |
| NHP2 | NHP2 ribonucleoprotein | -2.12521 |
| MRFAP1L1 | Morf4 family associated protein 1-like 1 | -2.12369 |
| RBL2 | retinoblastoma-like 2 | -2.10628 |
| PBK | PDZ binding kinase | -2.09559 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -2.09009 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -2.0858 |
| YME1L1 | YME1-like 1 ATPase | -2.07472 |
| RPL4 | ribosomal protein L4 | -2.07455 |
| MEMO1 | mediator of cell motility 1 | -2.07078 |
| PRMT3 | protein arginine methyltransferase 3 | -2.07062 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -2.06696 |
| CALU | calumenin | -2.06625 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -2.05683 |
| RRAGA | Ras-related GTP binding A | -2.04785 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -2.04719 |
| CENPE | centromere protein E, 312kDa | -2.04307 |
| YTHDF2 | YTH N(6)-methyladenosine RNA binding protein 2 | -2.03991 |
| UFSP2 | UFM1-specific peptidase 2 | -2.0396 |
| TSPYL1 | TSPY-like 1 | -2.03876 |
| RBMX | RNA binding motif protein, X-linked | -2.03432 |
| LOX | lysyl oxidase | -2.02631 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -2.01948 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -2.01258 |
| CIRBP | cold inducible RNA binding protein | -2.00698 |
| CENPF | centromere protein F, 350/400kDa | -2.00222 |
