CRCGN017_MCF10A.TP53.M_24H:N20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 33.62 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 4.83229
INTS3 integrator complex subunit 3 4.59977
STK10 serine/threonine kinase 10 3.94279
CXCR4 chemokine (C-X-C motif) receptor 4 3.47156
SKA1 spindle and kinetochore associated complex subunit 1 2.7881
INPP5F inositol polyphosphate-5-phosphatase F 2.53827
POU4F1 POU class 4 homeobox 1 2.31376
HNRNPM heterogeneous nuclear ribonucleoprotein M 2.30882
MPDU1 mannose-P-dolichol utilization defect 1 2.24227
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.15499
KIF11 kinesin family member 11 2.07244
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.04695
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.00844

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.03198
CDC20 cell division cycle 20 -4.95489
TUBB6 tubulin, beta 6 class V -4.16086
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.16016
LYPLA1 lysophospholipase I -3.95643
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.88935
ANXA2 annexin A2 -3.25262
EXOSC4 exosome component 4 -3.24734
LY86 lymphocyte antigen 86 -2.97003
HSPA1A heat shock 70kDa protein 1A -2.79692
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like -2.78111
BTK Bruton agammaglobulinemia tyrosine kinase -2.6223
LGALS1 lectin, galactoside-binding, soluble, 1 -2.58163
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.58053
PIH1D1 PIH1 domain containing 1 -2.45154
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.4215
MSMO1 methylsterol monooxygenase 1 -2.39877
RCOR3 REST corepressor 3 -2.36455
SOCS4 suppressor of cytokine signaling 4 -2.34394
CDKN3 cyclin-dependent kinase inhibitor 3 -2.28691
TMEM187 transmembrane protein 187 -2.28506
EMC9 ER membrane protein complex subunit 9 -2.26456
RBMX2 RNA binding motif protein, X-linked 2 -2.25931
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.24773
RPL10L ribosomal protein L10-like -2.15914
PAX6 paired box 6 -2.14968
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.1421
REXO5 RNA exonuclease 5 -2.1345
PRELID3A PRELI domain containing 3A -2.121
RWDD2B RWD domain containing 2B -2.11842
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.09169
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.0727
ZNF26 zinc finger protein 26 -2.05897
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.05019
CT55 cancer/testis antigen 55 -2.02129
GRN granulin -2.01409
GLRX2 glutaredoxin 2 -2.0108