CRCGN017_MCF10A.TP53.M_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indeno[1,2,3-cd]pyrene 33.92 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.23032
MAP7 microtubule-associated protein 7 3.80224
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.60312
FGFR4 fibroblast growth factor receptor 4 3.54429
HBB hemoglobin, beta 3.15985
HBA1 hemoglobin, alpha 1 3.0706
TBX2 T-box 2 2.91975
CSF3 colony stimulating factor 3 (granulocyte) 2.88803
ELAC2 elaC ribonuclease Z 2 2.7817
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.68147
ATAD2B ATPase family, AAA domain containing 2B 2.54263
TMEM204 transmembrane protein 204 2.46033
IGHMBP2 immunoglobulin mu binding protein 2 2.3875
MRPL19 mitochondrial ribosomal protein L19 2.36319
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.34835
IL20RA interleukin 20 receptor, alpha 2.1698
LXN latexin 2.15172
TMEM50A transmembrane protein 50A 2.13781
GCH1 GTP cyclohydrolase 1 2.10668
NUP62CL nucleoporin 62kDa C-terminal like 2.06829
PTK6 protein tyrosine kinase 6 2.0658
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.05152
RGS5 regulator of G-protein signaling 5 2.02885
RBM6 RNA binding motif protein 6 2.02647
CDC25B cell division cycle 25B 2.02284

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -6.23419
HMG20B high mobility group 20B -5.50533
PGAM4 phosphoglycerate mutase family member 4 -4.9413
TSPAN4 tetraspanin 4 -4.3477
PUF60 poly-U binding splicing factor 60KDa -4.34237
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.84058
TRAPPC3 trafficking protein particle complex 3 -3.55943
TUBA4A tubulin, alpha 4a -2.87533
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.70659
SPAG7 sperm associated antigen 7 -2.69145
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.51307
EYA2 EYA transcriptional coactivator and phosphatase 2 -2.44009
ENO2 enolase 2 (gamma, neuronal) -2.39601
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.29912
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.21425
PORCN porcupine homolog (Drosophila) -2.12382
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.11425
KRT17 keratin 17, type I -2.11168
RGS2 regulator of G-protein signaling 2 -2.07088
CUEDC2 CUE domain containing 2 -2.07052
RPL10A ribosomal protein L10a -2.05364