CRCGN017_MCF10A.TP53.M_24H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indeno[1,2,3-cd]pyrene 11.31 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 4.88691
EAPP E2F-associated phosphoprotein 4.88504
CDCA4 cell division cycle associated 4 4.09333
KDM5D lysine (K)-specific demethylase 5D 3.72594
ANO10 anoctamin 10 3.0302
SRP54 signal recognition particle 54kDa 2.92058
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.72276
RPL39L ribosomal protein L39-like 2.62851
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.53524
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.52407
MBIP MAP3K12 binding inhibitory protein 1 2.51684
SPTSSA serine palmitoyltransferase, small subunit A 2.4378
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.39402
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.16778
STK10 serine/threonine kinase 10 2.12068
RXYLT1 ribitol xylosyltransferase 1 2.06778
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.06743
EVL Enah/Vasp-like 2.0451

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.18816
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.17827
HMG20B high mobility group 20B -3.6505
PCNA proliferating cell nuclear antigen -3.28368
KDM3A lysine (K)-specific demethylase 3A -3.20476
SMC1A structural maintenance of chromosomes 1A -2.74212
UBA2 ubiquitin-like modifier activating enzyme 2 -2.59486
KDM5C lysine (K)-specific demethylase 5C -2.53225
EIF2D eukaryotic translation initiation factor 2D -2.44693
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.4187
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.34265
SRP9 signal recognition particle 9kDa -2.29735
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.21395
ZNF263 zinc finger protein 263 -2.12596
PHEX phosphate regulating endopeptidase homolog, X-linked -2.09153
THAP11 THAP domain containing 11 -2.0775
DCLRE1A DNA cross-link repair 1A -2.05469
OLAH oleoyl-ACP hydrolase -2.02981
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.00287