CRCGN017_MCF10A.TP53.M_24H:O02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.64902
KLHL21 kelch-like family member 21 4.97055
FGFR4 fibroblast growth factor receptor 4 4.23357
TIAM1 T-cell lymphoma invasion and metastasis 1 3.799
RBBP5 retinoblastoma binding protein 5 3.76865
MDM4 MDM4, p53 regulator 3.64645
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.62375
BMP4 bone morphogenetic protein 4 3.557
MTA2 metastasis associated 1 family, member 2 3.3986
ACAA1 acetyl-CoA acyltransferase 1 3.3632
RBP4 retinol binding protein 4, plasma 3.23755
USP9Y ubiquitin specific peptidase 9, Y-linked 3.1343
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.09392
TBX2 T-box 2 3.09298
RAB4A RAB4A, member RAS oncogene family 3.07758
C5 complement component 5 3.0595
LYN LYN proto-oncogene, Src family tyrosine kinase 2.998
GZMM granzyme M (lymphocyte met-ase 1) 2.7661
LGMN legumain 2.74525
PRKCH protein kinase C, eta 2.7418
ETV6 ets variant 6 2.7114
KRT33A keratin 33A, type I 2.7107
ZFY zinc finger protein, Y-linked 2.64265
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.62852
RYR3 ryanodine receptor 3 2.6218
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 2.6169
GTPBP8 GTP-binding protein 8 (putative) 2.60855
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.55835
NUTF2 nuclear transport factor 2 2.5576
KDM5D lysine (K)-specific demethylase 5D 2.5235
HBA1 hemoglobin, alpha 1 2.51933
SH2D1A SH2 domain containing 1A 2.48852
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.48545
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2.44285
RPH3A rabphilin 3A 2.43845
GSTCD glutathione S-transferase, C-terminal domain containing 2.43355
ZNF124 zinc finger protein 124 2.41655
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.4101
ZNF669 zinc finger protein 669 2.3925
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.39202
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.37245
TMEM51 transmembrane protein 51 2.3545
TOMM34 translocase of outer mitochondrial membrane 34 2.3338
GRAP2 GRB2-related adaptor protein 2 2.32815
NLGN4Y neuroligin 4, Y-linked 2.32575
TRAT1 T cell receptor associated transmembrane adaptor 1 2.3181
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.2978
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.243
SMIM41 small integral membrane protein 41 2.2373
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.23647
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.22745
CD28 CD28 molecule 2.21112
VSIG10 V-set and immunoglobulin domain containing 10 2.2083
MED31 mediator complex subunit 31 2.20055
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.1784
SPRING1 SREBF pathway regulator in golgi 1 2.17155
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.1689
RELN reelin 2.16235
TF transferrin 2.15322
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.15065
INCENP inner centromere protein antigens 135/155kDa 2.14125
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.11285
COMMD8 COMM domain containing 8 2.10755
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 2.10625
METTL8 methyltransferase like 8 2.10565
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.10345
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.10105
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 2.09655
APOM apolipoprotein M 2.0949
VAV3 vav 3 guanine nucleotide exchange factor 2.09317
CD247 CD247 molecule 2.0899
KANK1 KN motif and ankyrin repeat domains 1 2.08935
AMBP alpha-1-microglobulin/bikunin precursor 2.08445
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.07815
PIPOX pipecolic acid oxidase 2.07535
MED18 mediator complex subunit 18 2.07412
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.06145
TEP1 telomerase-associated protein 1 2.0574
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.05707
ATXN7L1 ataxin 7-like 1 2.0563
ZBTB18 zinc finger and BTB domain containing 18 2.05413
HP1BP3 heterochromatin protein 1, binding protein 3 2.0465
KRT33B keratin 33B, type I 2.04335
TMEM120B transmembrane protein 120B 2.0379
BCL2 B-cell CLL/lymphoma 2 2.0352
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.03125
ZNF143 zinc finger protein 143 2.0285
ZNF652 zinc finger protein 652 2.0265
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.0254
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.01755
FLCN folliculin 2.0059
ZNF253 zinc finger protein 253 2.00065

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.98357
BASP1 brain abundant, membrane attached signal protein 1 -4.4199
CANT1 calcium activated nucleotidase 1 -4.07553
GDF15 growth differentiation factor 15 -3.9879
UBA1 ubiquitin-like modifier activating enzyme 1 -3.3835
KDM5C lysine (K)-specific demethylase 5C -3.09965
CAB39 calcium binding protein 39 -3.0657
SMC1A structural maintenance of chromosomes 1A -2.99005
USP9X ubiquitin specific peptidase 9, X-linked -2.96892
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.83757
LOC124908558 X antigen family member 1-like -2.4826
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.4769
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -2.44665
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.4088
MAGEA1 melanoma antigen family A1 -2.3693
MAP1S microtubule-associated protein 1S -2.3685
RAB9A RAB9A, member RAS oncogene family -2.34045
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -2.334
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.3135
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.2507
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.16045
ANO10 anoctamin 10 -2.15495
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -2.1538
TUBA4A tubulin, alpha 4a -2.12295
ATG9A autophagy related 9A -2.05255
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -2.0497
CKAP5 cytoskeleton associated protein 5 -2.0465
CDK16 cyclin-dependent kinase 16 -2.0363
SMAP1 small ArfGAP 1 -2.0156
LOC100533997 MAGEA10-MAGEA5 readthrough -2.0151