CRCGN017_MCF10A.TP53.M_24H:O03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HYOU1 hypoxia up-regulated 1 4.23377
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.64689
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.45179
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.37433
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.243
AMDHD2 amidohydrolase domain containing 2 3.10402
TGFB3 transforming growth factor, beta 3 2.5612
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.46326
FPR3 formyl peptide receptor 3 2.43983
MYNN myoneurin 2.43527
PPP1R2C PPP1R2C family member C 2.42964
HSF4 heat shock transcription factor 4 2.31356
PDE7B phosphodiesterase 7B 2.31051
PGM5 phosphoglucomutase 5 2.30746
SLC22A14 solute carrier family 22, member 14 2.30263
CCNJL cyclin J-like 2.27962
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.24292
PRLH prolactin releasing hormone 2.23346
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 2.23009
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.22141
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.21582
CAMK1 calcium/calmodulin-dependent protein kinase I 2.20287
ZNF35 zinc finger protein 35 2.19051
SHH sonic hedgehog 2.16057
MAP2K5 mitogen-activated protein kinase kinase 5 2.15183
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.1505
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.13448
ZNF253 zinc finger protein 253 2.13136
IPO8 importin 8 2.12695
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.12277
HPCA hippocalcin 2.12039
TMEM242 transmembrane protein 242 2.11157
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.10913
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.10705
CCDC15 coiled-coil domain containing 15 2.1067
FAM110B family with sequence similarity 110, member B 2.0874
TEF thyrotrophic embryonic factor 2.08635
TREM2 triggering receptor expressed on myeloid cells 2 2.06814
HYDIN HYDIN, axonemal central pair apparatus protein 2.05943
PDCD1 programmed cell death 1 2.05786
AQP5 aquaporin 5 2.05292
TJP3 tight junction protein 3 2.04869
DNAH7 dynein, axonemal, heavy chain 7 2.04019
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.03798
ADGRG1 adhesion G protein-coupled receptor G1 2.02305
CCNK cyclin K 2.02284
DNAH3 dynein, axonemal, heavy chain 3 2.0216
KALRN kalirin, RhoGEF kinase 2.01982
RBP4 retinol binding protein 4, plasma 2.01042
GPR31 G protein-coupled receptor 31 2.01037
SAMD4B sterile alpha motif domain containing 4B 2.00974
DGKQ diacylglycerol kinase, theta 110kDa 2.00933
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.0015

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -4.2213
HSPA8 heat shock 70kDa protein 8 -3.24923
BASP1 brain abundant, membrane attached signal protein 1 -3.13971
PMM2 phosphomannomutase 2 -3.07707
YME1L1 YME1-like 1 ATPase -2.99592
KRT14 keratin 14, type I -2.91498
MACF1 microtubule-actin crosslinking factor 1 -2.84765
ELAC2 elaC ribonuclease Z 2 -2.51961
TM9SF2 transmembrane 9 superfamily member 2 -2.40308
TUBA4A tubulin, alpha 4a -2.35321
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.26255
AKAP11 A kinase (PRKA) anchor protein 11 -2.2586
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.25666
YY1AP1 YY1 associated protein 1 -2.25197
PROSER1 proline and serine rich 1 -2.20357
MRPS31 mitochondrial ribosomal protein S31 -2.18999
NAT10 N-acetyltransferase 10 (GCN5-related) -2.12123
SEC16A SEC16 homolog A (S. cerevisiae) -2.11637
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.10767
MAGED1 melanoma antigen family D1 -2.09968
CBR3 carbonyl reductase 3 -2.05438
CD81 CD81 molecule -2.05123
RPL36AL ribosomal protein L36a-like -2.04459