CRCGN017_MCF10A.TP53.M_24H:O04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.49126
STK10 serine/threonine kinase 10 5.15481
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.12415
SPAG4 sperm associated antigen 4 4.5045
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.45371
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 4.11768
AGR2 anterior gradient 2 3.74375
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.19523
FZD7 frizzled class receptor 7 2.75269
CTCF CCCTC-binding factor (zinc finger protein) 2.70267
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.58162
FUBP3 far upstream element (FUSE) binding protein 3 2.51309
NRBF2 nuclear receptor binding factor 2 2.4911
SERF1A small EDRK-rich factor 1A (telomeric) 2.28627
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2.28537
RBM22 RNA binding motif protein 22 2.23538
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.23362
ZBTB35 zinc finger and BTB domain containing 35 2.22289
CGRRF1 cell growth regulator with ring finger domain 1 2.14817
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.14526

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.43877
HAT1 histone acetyltransferase 1 -4.2572
PMM2 phosphomannomutase 2 -4.19454
KIF20A kinesin family member 20A -3.82165
NUP85 nucleoporin 85kDa -3.76788
GDF15 growth differentiation factor 15 -3.55879
TUBA4A tubulin, alpha 4a -3.46432
NT5DC2 5'-nucleotidase domain containing 2 -3.39114
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.37567
KDM3A lysine (K)-specific demethylase 3A -3.06353
GRN granulin -2.93536
MRPL58 mitochondrial ribosomal protein L58 -2.73529
PRUNE2 prune homolog 2 (Drosophila) -2.55255
TRIB3 tribbles pseudokinase 3 -2.55227
TMEM94 transmembrane protein 94 -2.30332
STXBP2 syntaxin binding protein 2 -2.07298
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.05606
SCN3A sodium channel, voltage gated, type III alpha subunit -2.01303