CRCGN017_MCF10A.TP53.M_24H:O10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-methylchrysene 97.88 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.6756
BTK Bruton agammaglobulinemia tyrosine kinase 2.70519
MAST2 microtubule associated serine/threonine kinase 2 2.69725
WIF1 WNT inhibitory factor 1 2.47103
METTL22 methyltransferase like 22 2.41402
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.32149
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.23677
VSIG4 V-set and immunoglobulin domain containing 4 2.21097
TMEM186 transmembrane protein 186 2.20002
UGDH UDP-glucose 6-dehydrogenase 2.18222

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -4.64934
DERA deoxyribose-phosphate aldolase (putative) -3.8926
SLC25A46 solute carrier family 25, member 46 -3.47624
VDAC1 voltage-dependent anion channel 1 -3.39196
HSPA8 heat shock 70kDa protein 8 -3.19753
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.73844
TNIP1 TNFAIP3 interacting protein 1 -2.61529
MSN moesin -2.45532
DYNLT3 dynein, light chain, Tctex-type 3 -2.40382
PFKP phosphofructokinase, platelet -2.32698
IGFBP7 insulin-like growth factor binding protein 7 -2.03511
FLT3 fms-related tyrosine kinase 3 -2.02328
KDM3A lysine (K)-specific demethylase 3A -2.01984
FER fer (fps/fes related) tyrosine kinase -2.01405