CRCGN017_MCF10A.TP53.M_24H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-methylchrysene 10.88 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 3.37627
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.7725
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.77166
HDGFL3 HDGF like 3 2.56952
GRB10 growth factor receptor-bound protein 10 2.55031
GRB7 growth factor receptor-bound protein 7 2.55006
TXNL4B thioredoxin-like 4B 2.50943
TBXA2R thromboxane A2 receptor 2.48272
STAP1 signal transducing adaptor family member 1 2.46844
ACAA1 acetyl-CoA acyltransferase 1 2.37786
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.37436
TRHR thyrotropin-releasing hormone receptor 2.33823
CHN1 chimerin 1 2.31797
PRDM9 PR domain containing 9 2.31354
MIMS2 mitochondrial inner membrane scaffold 2 2.30095
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.29589
UGP2 UDP-glucose pyrophosphorylase 2 2.29217
ZNF507 zinc finger protein 507 2.28299
PRKG1 protein kinase, cGMP-dependent, type I 2.27282
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.26255
FSHR follicle stimulating hormone receptor 2.25827
THRB thyroid hormone receptor, beta 2.25032
GRM6 glutamate receptor, metabotropic 6 2.24876
SNX11 sorting nexin 11 2.24783
CEP72 centrosomal protein 72kDa 2.24588
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.23315
ST7L suppression of tumorigenicity 7 like 2.23018
PRAMEF26 PRAME family member 26 2.22158
ARL15 ADP-ribosylation factor-like 15 2.21189
COL8A1 collagen, type VIII, alpha 1 2.21038
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.1942
ITGA1 integrin, alpha 1 2.19222
NPVF neuropeptide VF precursor 2.18907
CMKLR1 chemerin chemokine-like receptor 1 2.18237
MED31 mediator complex subunit 31 2.17908
SLAMF8 SLAM family member 8 2.17881
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.17316
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.16825
ADAT1 adenosine deaminase, tRNA-specific 1 2.16675
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.16424
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.15585
VEGFA vascular endothelial growth factor A 2.15043
PDCD1LG2 programmed cell death 1 ligand 2 2.14656
ZNF749 zinc finger protein 749 2.14299
MRPS18C mitochondrial ribosomal protein S18C 2.14245
ZNF816 zinc finger protein 816 2.14059
NMBR neuromedin B receptor 2.13989
CAPN11 calpain 11 2.12046
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.12014
NOL10 nucleolar protein 10 2.11822
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.11287
ADAMTSL3 ADAMTS-like 3 2.10853
LRTM1 leucine-rich repeats and transmembrane domains 1 2.10649
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.10244
BMP4 bone morphogenetic protein 4 2.10015
SCN3B sodium channel, voltage gated, type III beta subunit 2.09871
ARSJ arylsulfatase family, member J 2.08467
TEX13A testis expressed 13A 2.08433
PSG11 pregnancy specific beta-1-glycoprotein 11 2.08382
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.08259
CA7 carbonic anhydrase VII 2.08228
INHBC inhibin, beta C 2.08224
PKD2L2 polycystic kidney disease 2-like 2 2.07742
MYT1L myelin transcription factor 1-like 2.07544
TSHZ2 teashirt zinc finger homeobox 2 2.0704
FPR3 formyl peptide receptor 3 2.06424
LGALS12 lectin, galactoside-binding, soluble, 12 2.0638
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.06342
ZNF549 zinc finger protein 549 2.06341
PCDHA2 protocadherin alpha 2 2.05843
CIAO3 cytosolic iron-sulfur assembly component 3 2.05384
CALCRL calcitonin receptor-like 2.04933
IFNA7 interferon, alpha 7 2.04819
MOB3B MOB kinase activator 3B 2.04796
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.04578
VN1R1 vomeronasal 1 receptor 1 2.04502
SPATA31A3 SPATA31 subfamily A, member 3 2.04483
SCGB1D2 secretoglobin, family 1D, member 2 2.04446
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.04319
ATG10 autophagy related 10 2.03858
HCRTR1 hypocretin (orexin) receptor 1 2.03193
GK2 glycerol kinase 2 2.03057
MYEF2 myelin expression factor 2 2.02618
LPAR6 lysophosphatidic acid receptor 6 2.01883
ZNF250 zinc finger protein 250 2.01828
LOC124900193 uncharacterized LOC124900193 2.01648
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 2.01564
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.00971
NOX3 NADPH oxidase 3 2.00959
C5AR2 complement component 5a receptor 2 2.00942
GJA9 gap junction protein, alpha 9, 59kDa 2.00502
PPIAL4H peptidylprolyl isomerase A like 4H 2.00189
PMCH pro-melanin-concentrating hormone 2.00024

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -3.96695
KIF14 kinesin family member 14 -3.82749
RNF167 ring finger protein 167 -3.56495
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.35583
ACOT9 acyl-CoA thioesterase 9 -2.9646
HMG20B high mobility group 20B -2.86134
HSPA1A heat shock 70kDa protein 1A -2.83273
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.40857
MSN moesin -2.34453
PITPNA phosphatidylinositol transfer protein, alpha -2.32632
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.27247
PRDX4 peroxiredoxin 4 -2.25419
ANXA5 annexin A5 -2.08351
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.06375
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.05979