CRCGN017_MCF10A.TP53.M_24H:O13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description quinoline 101.17 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

242 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.32531
PEX11A peroxisomal biogenesis factor 11 alpha 5.24324
INTS3 integrator complex subunit 3 5.18636
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.68114
SNAP25 synaptosomal-associated protein, 25kDa 4.53544
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.01318
OLFML2B olfactomedin-like 2B 3.96095
USP18 ubiquitin specific peptidase 18 3.42304
PRKCH protein kinase C, eta 3.10517
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 3.02885
TGFB3 transforming growth factor, beta 3 2.94731
ZNF571 zinc finger protein 571 2.9185
ZNF518A zinc finger protein 518A 2.89897
WASF3 WAS protein family, member 3 2.87848
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.86114
SCYL2 SCY1-like 2 (S. cerevisiae) 2.85426
CROT carnitine O-octanoyltransferase 2.82293
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.82204
TXNL4B thioredoxin-like 4B 2.82088
STEAP4 STEAP family member 4 2.812
LGSN lengsin, lens protein with glutamine synthetase domain 2.78261
HBA1 hemoglobin, alpha 1 2.76795
TRAPPC13 trafficking protein particle complex 13 2.76399
ASTN2 astrotactin 2 2.70995
PRSS8 protease, serine, 8 2.7073
STMN2 stathmin 2 2.68076
ZFP37 ZFP37 zinc finger protein 2.66864
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.6641
ZNF780A zinc finger protein 780A 2.65197
ARHGAP12 Rho GTPase activating protein 12 2.65053
SRD5A3 steroid 5 alpha-reductase 3 2.64687
SLC30A10 solute carrier family 30, member 10 2.64297
SCRN3 secernin 3 2.63493
BBS10 Bardet-Biedl syndrome 10 2.6328
CSAD cysteine sulfinic acid decarboxylase 2.62778
COL4A5 collagen, type IV, alpha 5 2.61548
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.53825
ZNF287 zinc finger protein 287 2.53011
HBB hemoglobin, beta 2.52608
CD248 CD248 molecule, endosialin 2.52524
USP6NL USP6 N-terminal like 2.52336
CCDC15 coiled-coil domain containing 15 2.50587
FPGT fucose-1-phosphate guanylyltransferase 2.4838
EHF ets homologous factor 2.48119
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.46951
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.45984
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 2.45838
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.45664
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.44953
ADRB2 adrenoceptor beta 2, surface 2.43709
FRRS1L ferric-chelate reductase 1-like 2.43374
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.43061
TCIM transcriptional and immune response regulator 2.42769
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.4214
NDP Norrie disease (pseudoglioma) 2.41486
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.41145
RABEP1 rabaptin, RAB GTPase binding effector protein 1 2.39959
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.3938
BCL9 B-cell CLL/lymphoma 9 2.39203
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.39006
OCRL oculocerebrorenal syndrome of Lowe 2.3834
KIAA1549L KIAA1549-like 2.38253
ZFP2 ZFP2 zinc finger protein 2.38016
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.37809
CNGA3 cyclic nucleotide gated channel alpha 3 2.37616
UNC13B unc-13 homolog B (C. elegans) 2.3741
MFSD6 major facilitator superfamily domain containing 6 2.36938
SERTAD2 SERTA domain containing 2 2.36767
CDO1 cysteine dioxygenase type 1 2.36541
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.36369
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.35979
VSNL1 visinin-like 1 2.34811
CLCA4 chloride channel accessory 4 2.34795
MCC mutated in colorectal cancers 2.34369
IL2RB interleukin 2 receptor, beta 2.34025
KLHL12 kelch-like family member 12 2.34022
BBS4 Bardet-Biedl syndrome 4 2.33152
GSTCD glutathione S-transferase, C-terminal domain containing 2.33043
HP1BP3 heterochromatin protein 1, binding protein 3 2.32288
SYT1 synaptotagmin I 2.32212
IKZF2 IKAROS family zinc finger 2 (Helios) 2.30982
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.29788
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.29741
CLUL1 clusterin-like 1 (retinal) 2.29517
NUP153 nucleoporin 153kDa 2.28856
PEDS1 plasmanylethanolamine desaturase 1 2.28691
COL15A1 collagen, type XV, alpha 1 2.27895
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.27829
ADGRL3 adhesion G protein-coupled receptor L3 2.27672
FXYD3 FXYD domain containing ion transport regulator 3 2.27358
TMEM254 transmembrane protein 254 2.27247
GLCE glucuronic acid epimerase 2.26661
COMP cartilage oligomeric matrix protein 2.26254
IRF6 interferon regulatory factor 6 2.26225
FBLN2 fibulin 2 2.26175
LTN1 listerin E3 ubiquitin protein ligase 1 2.26037
CEP290 centrosomal protein 290kDa 2.25881
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.25867
ITGB8 integrin, beta 8 2.2571
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.23996
RIC3 RIC3 acetylcholine receptor chaperone 2.23449
GRHL2 grainyhead-like 2 (Drosophila) 2.23416
MEOX2 mesenchyme homeobox 2 2.2311
MORC3 MORC family CW-type zinc finger 3 2.22844
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.22495
RORB RAR-related orphan receptor B 2.22175
THTPA thiamine triphosphatase 2.21745
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough 2.21563
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.20713
SYTL2 synaptotagmin-like 2 2.20695
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 2.20346
PI15 peptidase inhibitor 15 2.20311
PLAC1 placenta-specific 1 2.20283
LETMD1 LETM1 domain containing 1 2.20217
ZNF322 zinc finger protein 322 2.20077
NFIL3 nuclear factor, interleukin 3 regulated 2.19879
CILK1 ciliogenesis associated kinase 1 2.19579
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.19345
MECR mitochondrial trans-2-enoyl-CoA reductase 2.19184
MARK1 MAP/microtubule affinity-regulating kinase 1 2.19081
NSG2 neuronal vesicle trafficking associated 2 2.18978
PIGR polymeric immunoglobulin receptor 2.18876
SPRYD7 SPRY domain containing 7 2.18793
MTNAP1 mitochondrial nucleoid associated protein 1 2.18627
WDFY3 WD repeat and FYVE domain containing 3 2.18617
GATA3 GATA binding protein 3 2.17895
OTOR otoraplin 2.17894
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.17776
NOD1 nucleotide-binding oligomerization domain containing 1 2.17734
ANKRD17 ankyrin repeat domain 17 2.17729
COL3A1 collagen, type III, alpha 1 2.17559
GDAP1 ganglioside induced differentiation associated protein 1 2.17375
RAB27B RAB27B, member RAS oncogene family 2.17279
TBX21 T-box 21 2.15499
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.14513
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.14305
ZNF750 zinc finger protein 750 2.13779
METTL4 methyltransferase like 4 2.1347
SPARCL1 SPARC-like 1 (hevin) 2.13264
TMEM168 transmembrane protein 168 2.13151
IPO8 importin 8 2.12452
MSTN myostatin 2.12256
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.11926
SV2B synaptic vesicle glycoprotein 2B 2.11809
MON2 MON2 homolog (S. cerevisiae) 2.11475
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2.10108
ZNF460 zinc finger protein 460 2.09506
DAPK2 death-associated protein kinase 2 2.09154
SENP7 SUMO1/sentrin specific peptidase 7 2.09097
WDR59 WD repeat domain 59 2.08888
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.08804
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.08481
IL1R1 interleukin 1 receptor, type I 2.08152
LOC122526780 uncharacterized LOC122526780 2.07701
DZIP3 DAZ interacting zinc finger protein 3 2.07689
N4BP3 NEDD4 binding protein 3 2.07439
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.07401
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.07
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.06052
CLEC1A C-type lectin domain family 1, member A 2.04712
TRIL TLR4 interactor with leucine-rich repeats 2.04185
AQP4 aquaporin 4 2.04111
RRH retinal pigment epithelium-derived rhodopsin homolog 2.03975
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.03849
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.03802
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.0371
CCDC121 coiled-coil domain containing 121 2.0356
AK5 adenylate kinase 5 2.02859
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.02786
CCNT2 cyclin T2 2.0243
PRKCD protein kinase C, delta 2.02426
CEP192 centrosomal protein 192kDa 2.02399
ILF2 interleukin enhancer binding factor 2 2.02384
FAM200C family with sequence similarity 200 member C 2.02007
ZNF613 zinc finger protein 613 2.01918
GCLC glutamate-cysteine ligase, catalytic subunit 2.01505
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.01502
KATNBL1 katanin p80 subunit B-like 1 2.01475
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.01456
RTN1 reticulon 1 2.01381
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.0136
SMIM8 small integral membrane protein 8 2.01287
CD247 CD247 molecule 2.01251
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.01222
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.0066
ZNF559-ZNF177 ZNF559-ZNF177 readthrough 2.00634
RSBN1 round spermatid basic protein 1 2.00536
DAND5 DAN domain family member 5, BMP antagonist 2.00426
MTERF4 mitochondrial transcription termination factor 4 2.00117

decreased expression

Symbol Name Standardized Value
THAP11 THAP domain containing 11 -6.26947
ACOT9 acyl-CoA thioesterase 9 -5.74968
TES testin LIM domain protein -4.91363
DYNLT3 dynein, light chain, Tctex-type 3 -4.72509
TM9SF2 transmembrane 9 superfamily member 2 -4.40023
GRWD1 glutamate-rich WD repeat containing 1 -3.79649
CAB39 calcium binding protein 39 -3.5026
MSN moesin -3.41806
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -3.28404
RPN1 ribophorin I -3.1081
APOO apolipoprotein O -3.06818
CCDC69 coiled-coil domain containing 69 -3.00602
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.96709
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.79195
AVEN apoptosis, caspase activation inhibitor -2.72253
TRIM44 tripartite motif containing 44 -2.66048
PRDX4 peroxiredoxin 4 -2.65421
WWC3 WWC family member 3 -2.65303
KRT18 keratin 18, type I -2.59771
NRIP1 nuclear receptor interacting protein 1 -2.55285
CBR3 carbonyl reductase 3 -2.48922
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.48512
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.46928
CDCP1 CUB domain containing protein 1 -2.4056
HCCS holocytochrome c synthase -2.39922
RAI1 retinoic acid induced 1 -2.39434
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.38153
NARS1 asparaginyl-tRNA synthetase 1 -2.37841
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.34221
CNOT9 CCR4-NOT transcription complex subunit 9 -2.29934
SFXN3 sideroflexin 3 -2.29156
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -2.2872
DVL1 dishevelled segment polarity protein 1 -2.25016
TPP2 tripeptidyl peptidase II -2.2468
GFUS GDP-L-fucose synthase -2.23017
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.22174
PCCB propionyl CoA carboxylase, beta polypeptide -2.2197
BTBD1 BTB (POZ) domain containing 1 -2.19662
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.18909
RBM34 RNA binding motif protein 34 -2.1665
MSMO1 methylsterol monooxygenase 1 -2.14215
DDIT4 DNA-damage-inducible transcript 4 -2.13976
NUP93 nucleoporin 93kDa -2.12748
NME7 NME/NM23 family member 7 -2.12391
ARCN1 archain 1 -2.11869
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.10881
TMED1 transmembrane emp24 protein transport domain containing 1 -2.08962
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -2.06672
ELAC2 elaC ribonuclease Z 2 -2.06203
FLT3 fms-related tyrosine kinase 3 -2.05609
STXBP2 syntaxin binding protein 2 -2.05038
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.0416
OXCT1 3-oxoacid CoA transferase 1 -2.02814