CRCGN017_MCF10A.TP53.M_24H:O14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description quinoline 33.72 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

136 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 4.47032
BID BH3 interacting domain death agonist 3.56746
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 3.07151
SMIM40 small integral membrane protein 40 2.99595
OLFM1 olfactomedin 1 2.99398
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.93867
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.90816
TRHDE thyrotropin-releasing hormone degrading enzyme 2.80666
HBB hemoglobin, beta 2.79936
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.79886
CXCR4 chemokine (C-X-C motif) receptor 4 2.77251
KDM5D lysine (K)-specific demethylase 5D 2.75225
FBXL12 F-box and leucine-rich repeat protein 12 2.74132
EPHA3 EPH receptor A3 2.69882
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.62142
GRB7 growth factor receptor-bound protein 7 2.60676
ARMCX2 armadillo repeat containing, X-linked 2 2.57528
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.4922
TERT telomerase reverse transcriptase 2.48773
MMP2 matrix metallopeptidase 2 2.46294
HOOK1 hook microtubule-tethering protein 1 2.4566
CDK14 cyclin-dependent kinase 14 2.45539
RPL39L ribosomal protein L39-like 2.43429
TEDC2 tubulin epsilon and delta complex 2 2.41875
RSF1 remodeling and spacing factor 1 2.39522
RBM41 RNA binding motif protein 41 2.34929
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.33496
VENTX VENT homeobox 2.32858
CPE carboxypeptidase E 2.31437
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.31283
CRELD2 cysteine-rich with EGF-like domains 2 2.31241
NLGN4Y neuroligin 4, Y-linked 2.30054
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.28452
ZNF257 zinc finger protein 257 2.27861
CEP152 centrosomal protein 152kDa 2.27786
SNCB synuclein, beta 2.27152
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.26979
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.25622
ZNF273 zinc finger protein 273 2.25452
HTD2 hydroxyacyl-thioester dehydratase type 2 2.23621
ZNF675 zinc finger protein 675 2.23169
USP9Y ubiquitin specific peptidase 9, Y-linked 2.21823
CADM1 cell adhesion molecule 1 2.21298
FBXO11 F-box protein 11 2.2084
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.20825
WDR7 WD repeat domain 7 2.20482
CDC37L1 cell division cycle 37-like 1 2.20274
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.19624
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.19018
MTAP methylthioadenosine phosphorylase 2.18935
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.18209
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.17496
PCDHA9 protocadherin alpha 9 2.17465
ZNF559-ZNF177 ZNF559-ZNF177 readthrough 2.1674
ECHDC3 enoyl CoA hydratase domain containing 3 2.16079
KLF3 Kruppel-like factor 3 (basic) 2.14741
FGF16 fibroblast growth factor 16 2.14338
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.14127
ZNF141 zinc finger protein 141 2.14111
DCC DCC netrin 1 receptor 2.13792
GRM2 glutamate receptor, metabotropic 2 2.13779
SEZ6L seizure related 6 homolog (mouse)-like 2.12667
LAP3 leucine aminopeptidase 3 2.1224
MAGIX MAGI family member, X-linked 2.11648
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.11044
IGFBP5 insulin-like growth factor binding protein 5 2.10369
ZNF232 zinc finger protein 232 2.10162
ZNF135 zinc finger protein 135 2.10048
PPOX protoporphyrinogen oxidase 2.10009
ZNF208 zinc finger protein 208 2.10002
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.09462
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.09281
MRPS18C mitochondrial ribosomal protein S18C 2.08666
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.08633
ICAM5 intercellular adhesion molecule 5, telencephalin 2.07922
TESK1 testis-specific kinase 1 2.0745
SALL2 spalt-like transcription factor 2 2.06938
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.06778
IL36R interleukin 36 receptor 2.05923
DBF4B DBF4 zinc finger B 2.05757
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.05578
QSER1 glutamine and serine rich 1 2.05545
FZD1 frizzled class receptor 1 2.05489
GPR63 G protein-coupled receptor 63 2.05341
MOB3B MOB kinase activator 3B 2.05125
SH3GL2 SH3-domain GRB2-like 2 2.04807
FGFR2 fibroblast growth factor receptor 2 2.04373
VASH2 vasohibin 2 2.04342
IMPACT impact RWD domain protein 2.03918
UTF1 undifferentiated embryonic cell transcription factor 1 2.03704
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.03335
HPX hemopexin 2.0324
CSAD cysteine sulfinic acid decarboxylase 2.0309
ZNF778 zinc finger protein 778 2.02982
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.02626
ZNF804A zinc finger protein 804A 2.02261
POU5F1 POU class 5 homeobox 1 2.01989
CDC40 cell division cycle 40 2.0162
SYN1 synapsin I 2.01332
CIAO3 cytosolic iron-sulfur assembly component 3 2.00892
PAX7 paired box 7 2.00663
SUSD4 sushi domain containing 4 2.00615
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.00611
ZNF253 zinc finger protein 253 2.00324
WNT1 wingless-type MMTV integration site family, member 1 2.00245

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -4.38645
HAT1 histone acetyltransferase 1 -3.81387
GRN granulin -3.53742
MSN moesin -3.1177
CCNB1 cyclin B1 -2.93761
FASTKD5 FAST kinase domains 5 -2.88564
SCYL3 SCY1-like 3 (S. cerevisiae) -2.78694
SQSTM1 sequestosome 1 -2.6559
SMC1A structural maintenance of chromosomes 1A -2.53062
FPGS folylpolyglutamate synthase -2.46616
KDM5C lysine (K)-specific demethylase 5C -2.44973
UBE2S ubiquitin-conjugating enzyme E2S -2.42025
RAB1B RAB1B, member RAS oncogene family -2.3571
CDC20 cell division cycle 20 -2.33462
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.28236
FBXO7 F-box protein 7 -2.22129
LOC112694756 uncharaterized LOC112694756 -2.19782
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.19617
TMEM109 transmembrane protein 109 -2.19062
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.16659
GIPC1 GIPC PDZ domain containing family, member 1 -2.16504
CLTC clathrin, heavy chain (Hc) -2.15522
PNKP polynucleotide kinase 3'-phosphatase -2.13554
PRKCH protein kinase C, eta -2.11469
CKAP5 cytoskeleton associated protein 5 -2.10776
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.10153
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.08839
VAT1 vesicle amine transport 1 -2.07314
CTPS1 CTP synthase 1 -2.07192
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.06119
TSC22D4 TSC22 domain family, member 4 -2.01314