CRCGN017_MCF10A.TP53.M_24H:O15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description quinoline 11.24 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CANT1 calcium activated nucleotidase 1 4.94316
ITFG1 integrin alpha FG-GAP repeat containing 1 4.84975
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.74546
HBB hemoglobin, beta 3.40701
TSPAN6 tetraspanin 6 3.19911
FOS FBJ murine osteosarcoma viral oncogene homolog 3.12533
SMIM40 small integral membrane protein 40 2.97047
FCHO1 FCH domain only 1 2.82424
CDK7 cyclin-dependent kinase 7 2.68063
AGR2 anterior gradient 2 2.62142
EXTL2 exostosin-like glycosyltransferase 2 2.3587
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.26548
COMP cartilage oligomeric matrix protein 2.23965
TERT telomerase reverse transcriptase 2.16333
BIRC2 baculoviral IAP repeat containing 2 2.13798
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.12986
SNX7 sorting nexin 7 2.06873
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.0267

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.10648
NUP85 nucleoporin 85kDa -5.09424
GRN granulin -5.00315
HMG20B high mobility group 20B -4.75861
KRT14 keratin 14, type I -4.24529
TUBA4A tubulin, alpha 4a -4.00219
PCNA proliferating cell nuclear antigen -2.94152
ANXA2 annexin A2 -2.60173
PIH1D1 PIH1 domain containing 1 -2.57436
MRPS7 mitochondrial ribosomal protein S7 -2.57254
SUMO4 small ubiquitin-like modifier 4 -2.57138
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.57102
MRPL58 mitochondrial ribosomal protein L58 -2.56268
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.50538
GRWD1 glutamate-rich WD repeat containing 1 -2.41988
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.35621
GRB2 growth factor receptor-bound protein 2 -2.32956
KCTD2 potassium channel tetramerization domain containing 2 -2.30529
TMEM94 transmembrane protein 94 -2.29594
CASKIN2 CASK interacting protein 2 -2.18346
NT5C 5', 3'-nucleotidase, cytosolic -2.15871
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.14773
RPL38 ribosomal protein L38 -2.14304
JPT1 Jupiter microtubule associated homolog 1 -2.11861
CDR2L cerebellar degeneration-related protein 2-like -2.08521
ACTG1 actin gamma 1 -2.07492
RPL8 ribosomal protein L8 -2.06908
HSPA1A heat shock 70kDa protein 1A -2.06496
TATDN2 TatD DNase domain containing 2 -2.06142
SAP30BP SAP30 binding protein -2.02335