CRCGN017_MCF10A.TP53.M_24H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dichlorvos 101.38 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.46447
RBP4 retinol binding protein 4, plasma 3.66237
IFNAR1 interferon (alpha, beta and omega) receptor 1 3.57316
GRB10 growth factor receptor-bound protein 10 3.08943
ABHD6 abhydrolase domain containing 6 2.83905
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.62672
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.36179
IL10 interleukin 10 2.297
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.28666
CCDC92 coiled-coil domain containing 92 2.27353
SPRYD7 SPRY domain containing 7 2.17599
FHL5 four and a half LIM domains 5 2.17262
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.17025
ENDOU endonuclease, polyU-specific 2.15339
TRMT9B tRNA methyltransferase 9B (putative) 2.14368
ZNF460 zinc finger protein 460 2.10498
SLC38A4 solute carrier family 38, member 4 2.09832
ZNF81 zinc finger protein 81 2.09764
FAM135A family with sequence similarity 135, member A 2.09698
SPO11 SPO11 meiotic protein covalently bound to DSB 2.09599
IFNA1 interferon, alpha 1 2.08241
NSUN7 NOP2/Sun domain family, member 7 2.08092
AGBL3 ATP/GTP binding protein-like 3 2.08079
KRT36 keratin 36, type I 2.07705
FAM13C family with sequence similarity 13, member C 2.07053
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa 2.07047
SPATA6L spermatogenesis associated 6-like 2.04856
ZNF571 zinc finger protein 571 2.03022
PLN phospholamban 2.02999
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.02385
GCM2 glial cells missing homolog 2 (Drosophila) 2.02088
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.01922
TEX12 testis expressed 12 2.01823
USH2A Usher syndrome 2A (autosomal recessive, mild) 2.01596
ZNF80 zinc finger protein 80 2.01489
PTPRJ protein tyrosine phosphatase, receptor type, J 2.00734
ZNF471 zinc finger protein 471 2.00666
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.0063
PDE12 phosphodiesterase 12 2.0045
TAS2R13 taste receptor, type 2, member 13 2.00322
ZMYM6 zinc finger, MYM-type 6 2.00184
SPICE1 spindle and centriole associated protein 1 2.00156
ZBTB33 zinc finger and BTB domain containing 33 2.00037

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -5.36608
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -5.08778
CCNB2 cyclin B2 -4.99878
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.70948
KIF14 kinesin family member 14 -4.42897
HMG20B high mobility group 20B -4.30574
HSPA8 heat shock 70kDa protein 8 -4.17661
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.04681
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.76198
KIF20A kinesin family member 20A -2.70921
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.61203
GDF15 growth differentiation factor 15 -2.57531
EIF3L eukaryotic translation initiation factor 3, subunit L -2.39976
RPL4 ribosomal protein L4 -2.21835
CD81 CD81 molecule -2.17923
RPL6 ribosomal protein L6 -2.13548
RPL10A ribosomal protein L10a -2.06248
EIF3H eukaryotic translation initiation factor 3, subunit H -2.05365
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.03971
HOXA5 homeobox A5 -2.02595