CRCGN017_MCF10A.TP53.M_24H:O17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dichlorvos 33.79 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 4.61072
FGFR4 fibroblast growth factor receptor 4 3.43148
CCDC86 coiled-coil domain containing 86 2.88708
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.79336
GLI2 GLI family zinc finger 2 2.69491
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.45555
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.4452
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.44172
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.4138
GHR growth hormone receptor 2.39933
SPINK5 serine peptidase inhibitor, Kazal type 5 2.37199
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.33752
MMP1 matrix metallopeptidase 1 2.30095
C1QA complement component 1, q subcomponent, A chain 2.25583
ENOSF1 enolase superfamily member 1 2.24557
SPDEF SAM pointed domain containing ETS transcription factor 2.21384
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.2042
HOXB2 homeobox B2 2.15943
C1QB complement component 1, q subcomponent, B chain 2.15337
NUP133 nucleoporin 133kDa 2.14589
BAALC brain and acute leukemia, cytoplasmic 2.13956
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.09129
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.08976
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.08465
TCTA T-cell leukemia translocation altered 2.07374
RHOH ras homolog family member H 2.05308
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.03876
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.02171
STAP1 signal transducing adaptor family member 1 2.01738
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 2.01325
MACF1 microtubule-actin crosslinking factor 1 2.00757
NXT2 nuclear transport factor 2-like export factor 2 2.00523

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -5.8222
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -4.07714
RPN1 ribophorin I -3.92173
UBE3C ubiquitin protein ligase E3C -3.7953
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -3.44045
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -3.2436
EXOSC4 exosome component 4 -3.13817
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.02723
BASP1 brain abundant, membrane attached signal protein 1 -2.88771
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.86907
HSPA1A heat shock 70kDa protein 1A -2.83742
MALT1 MALT1 paracaspase -2.63246
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.61851
SQOR sulfide quinone oxidoreductase -2.43158
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.39405
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.38653
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.37853
NUP93 nucleoporin 93kDa -2.30626
FBXO21 F-box protein 21 -2.24921
DDIT4 DNA-damage-inducible transcript 4 -2.2122
GFUS GDP-L-fucose synthase -2.20722
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.20174
UBE2C ubiquitin-conjugating enzyme E2C -2.1925
RAD51C RAD51 paralog C -2.07367
EMC9 ER membrane protein complex subunit 9 -2.07237