CRCGN017_MCF10A.TP53.M_24H:O19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-naphthylamine 102.67 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HYOU1 hypoxia up-regulated 1 4.49825
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 3.55235
MMP1 matrix metallopeptidase 1 3.50136
COMP cartilage oligomeric matrix protein 3.28216
ABHD4 abhydrolase domain containing 4 3.24403
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 3.10825
MAP7 microtubule-associated protein 7 2.90933
WDR7 WD repeat domain 7 2.90193
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.75104
ACAA1 acetyl-CoA acyltransferase 1 2.60275
GRB7 growth factor receptor-bound protein 7 2.41972
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.31783
PLA2G15 phospholipase A2, group XV 2.30846
LGMN legumain 2.19785
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.19072
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.10852
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.07948
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.07251
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 2.06809
HBB hemoglobin, beta 2.06494
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.06086
PCDHA9 protocadherin alpha 9 2.05297
DDR1 discoidin domain receptor tyrosine kinase 1 2.04629
CCDC85B coiled-coil domain containing 85B 2.03148
ZNF304 zinc finger protein 304 2.018

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -3.98367
HMG20B high mobility group 20B -3.25278
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.11896
UFM1 ubiquitin-fold modifier 1 -3.07643
PCCB propionyl CoA carboxylase, beta polypeptide -2.42603
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.40989
DYNLRB1 dynein, light chain, roadblock-type 1 -2.38598
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.29387
GRWD1 glutamate-rich WD repeat containing 1 -2.26374
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.22159
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.1927
WWC3 WWC family member 3 -2.06825
WASF2 WAS protein family, member 2 -2.05081
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.04601
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.02393
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.0116
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.00655
TAC4 tachykinin 4 (hemokinin) -2.00496