CRCGN017_MCF10A.TP53.M_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-naphthylamine 34.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

362 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.32196
KLHL21 kelch-like family member 21 3.76245
E2F2 E2F transcription factor 2 3.72485
FGF8 fibroblast growth factor 8 (androgen-induced) 3.26142
MYH13 myosin, heavy chain 13, skeletal muscle 3.2536
HOXD12 homeobox D12 3.22223
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.13339
NMUR1 neuromedin U receptor 1 3.12484
TSSK2 testis-specific serine kinase 2 3.11574
AMDHD2 amidohydrolase domain containing 2 3.09008
PPP1R2C PPP1R2C family member C 2.98007
ANGPT4 angiopoietin 4 2.97634
SOX1 SRY (sex determining region Y)-box 1 2.97506
POU4F3 POU class 4 homeobox 3 2.92806
NEUROG2 neurogenin 2 2.82788
TEF thyrotrophic embryonic factor 2.8156
FSCN2 fascin actin-bundling protein 2, retinal 2.80673
FOXB1 forkhead box B1 2.78806
LINS1 lines homolog 1 2.77996
TEX13A testis expressed 13A 2.76811
SPATA31A3 SPATA31 subfamily A, member 3 2.76741
GSC2 goosecoid homeobox 2 2.72179
DOT1L DOT1-like histone H3K79 methyltransferase 2.69944
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.68593
RAB21 RAB21, member RAS oncogene family 2.68202
LBX1 ladybird homeobox 1 2.67416
TSSK1B testis-specific serine kinase 1B 2.64227
SPATA1 spermatogenesis associated 1 2.63032
MMP1 matrix metallopeptidase 1 2.6134
LYN LYN proto-oncogene, Src family tyrosine kinase 2.58762
MRPS18C mitochondrial ribosomal protein S18C 2.58153
HCRTR1 hypocretin (orexin) receptor 1 2.55825
ALX4 ALX homeobox 4 2.55789
CBARP CACN subunit beta associated regulatory protein 2.55725
SNTG2 syntrophin, gamma 2 2.54253
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.53795
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.53619
PTTG2 pituitary tumor-transforming 2 2.53391
TREH trehalase (brush-border membrane glycoprotein) 2.53313
SOX14 SRY (sex determining region Y)-box 14 2.52755
LGMN legumain 2.50238
CDX4 caudal type homeobox 4 2.50167
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.49663
SHH sonic hedgehog 2.49359
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.48822
GALR2 galanin receptor 2 2.48569
FOXD3 forkhead box D3 2.48279
FBXO24 F-box protein 24 2.48076
GPR68 G protein-coupled receptor 68 2.47268
SSTR5 somatostatin receptor 5 2.46635
NKX6-1 NK6 homeobox 1 2.46343
DUSP21 dual specificity phosphatase 21 2.45715
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.4421
KMT2D lysine (K)-specific methyltransferase 2D 2.43782
ADGRB1 adhesion G protein-coupled receptor B1 2.43757
PITPNM3 PITPNM family member 3 2.43242
DGKQ diacylglycerol kinase, theta 110kDa 2.4303
EPHA5 EPH receptor A5 2.42925
MMP2 matrix metallopeptidase 2 2.42763
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.42642
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.40764
PAX3 paired box 3 2.40575
XCR1 chemokine (C motif) receptor 1 2.40528
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 2.38602
RFXAP regulatory factor X-associated protein 2.38404
FN3K fructosamine 3 kinase 2.37686
CABP2 calcium binding protein 2 2.37584
GSG1 germ cell associated 1 2.37503
ZNRF4 zinc and ring finger 4 2.36142
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.36134
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.35974
ACE angiotensin I converting enzyme 2.35883
TLX3 T-cell leukemia homeobox 3 2.35724
SCRT1 scratch family zinc finger 1 2.35188
POU3F3 POU class 3 homeobox 3 2.35098
OMP olfactory marker protein 2.35034
SSTR1 somatostatin receptor 1 2.34738
MC3R melanocortin 3 receptor 2.34341
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.34309
TEX28 testis expressed 28 2.34212
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 2.33939
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.3393
GUCY2F guanylate cyclase 2F, retinal 2.33647
ELOA2 elongin A2 2.33559
PCDHGA11 protocadherin gamma subfamily A, 11 2.33498
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.33064
TMEM223 transmembrane protein 223 2.32917
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.32163
RAPSN receptor-associated protein of the synapse 2.31877
WNT3 wingless-type MMTV integration site family, member 3 2.31844
PXDNL peroxidasin-like 2.31223
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.31079
PRDM9 PR domain containing 9 2.30741
ADRB1 adrenoceptor beta 1 2.30644
OR10H2 olfactory receptor, family 10, subfamily H, member 2 2.30554
MRLN myoregulin 2.30517
GPR27 G protein-coupled receptor 27 2.30383
TEX12 testis expressed 12 2.29988
CNTNAP3B contactin associated protein-like 3B 2.29922
ETV2 ets variant 2 2.29905
EFNA2 ephrin-A2 2.29835
DRD3 dopamine receptor D3 2.29823
IRGC immunity-related GTPase family, cinema 2.29768
ADRA1B adrenoceptor alpha 1B 2.29552
ATXN7L1 ataxin 7-like 1 2.29548
CBX2 chromobox homolog 2 2.29404
AKAP4 A kinase (PRKA) anchor protein 4 2.29229
ACTL7A actin-like 7A 2.2908
GNRH2 gonadotropin-releasing hormone 2 2.28914
RERGL RERG/RAS-like 2.28901
LOC102724652 alpha-crystallin A chain 2.288
HOXA6 homeobox A6 2.28785
RCVRN recoverin 2.2867
JPH3 junctophilin 3 2.28573
OXT oxytocin/neurophysin I prepropeptide 2.28337
AANAT aralkylamine N-acetyltransferase 2.28111
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.27798
ZNF549 zinc finger protein 549 2.27367
TNP2 transition protein 2 (during histone to protamine replacement) 2.27329
LRIT1 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 2.27228
HOXA10 homeobox A10 2.26867
LATS1 large tumor suppressor kinase 1 2.26652
ZNF80 zinc finger protein 80 2.26583
ADRA1D adrenoceptor alpha 1D 2.26467
CRYBA1 crystallin, beta A1 2.26321
PPIAL4H peptidylprolyl isomerase A like 4H 2.26207
DCHS2 dachsous cadherin-related 2 2.26034
ZNF407 zinc finger protein 407 2.2566
PCDHA2 protocadherin alpha 2 2.25539
OR1A2 olfactory receptor, family 1, subfamily A, member 2 2.25416
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.2524
KLK15 kallikrein-related peptidase 15 2.25112
GTPBP10 GTP-binding protein 10 (putative) 2.25005
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.24951
LMTK2 lemur tyrosine kinase 2 2.24791
MGAM2 maltase-glucoamylase 2 (putative) 2.24779
DNAAF8 dynein axonemal assembly factor 8 2.24516
CAPN11 calpain 11 2.24376
LGALS12 lectin, galactoside-binding, soluble, 12 2.24094
BMP4 bone morphogenetic protein 4 2.24005
ZNF480 zinc finger protein 480 2.23933
C8G complement component 8, gamma polypeptide 2.23904
HIC1 hypermethylated in cancer 1 2.23732
OR2J2 olfactory receptor, family 2, subfamily J, member 2 2.23687
MYO15A myosin XVA 2.23573
FAM135A family with sequence similarity 135, member A 2.23233
LINC02854 long intergenic non-protein coding RNA 2854 2.23143
CFAP46 cilia and flagella associated protein 46 2.23089
H1-1 H1.1 linker histone, cluster member 2.22964
TULP1 tubby like protein 1 2.22896
MTMR7 myotubularin related protein 7 2.2267
POU6F2 POU class 6 homeobox 2 2.22499
CATSPERG catsper channel auxiliary subunit gamma 2.22451
RFPL1 ret finger protein-like 1 2.22446
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 2.2239
ZNF37A zinc finger protein 37A 2.22219
IFT54 intraflagellar transport 54 2.2215
AMELX amelogenin, X-linked 2.21971
SPICE1 spindle and centriole associated protein 1 2.21799
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.21789
DRD4 dopamine receptor D4 2.21637
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.21457
SAMD4B sterile alpha motif domain containing 4B 2.20765
TP73 tumor protein p73 2.20729
CRHR2 corticotropin releasing hormone receptor 2 2.2062
ZXDB zinc finger, X-linked, duplicated B 2.20408
CYSLTR1 cysteinyl leukotriene receptor 1 2.20404
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.20214
FAM13C family with sequence similarity 13, member C 2.20173
H4C7 H4 clustered histone 7 2.19919
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 2.1959
PBOV1 prostate and breast cancer overexpressed 1 2.19553
CRYBB1 crystallin, beta B1 2.1939
DCC DCC netrin 1 receptor 2.19141
IREB2 iron-responsive element binding protein 2 2.18421
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.18371
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.18167
MSH4 mutS homolog 4 2.18167
GRID2 glutamate receptor, ionotropic, delta 2 2.17932
PGK2 phosphoglycerate kinase 2 2.17689
CDADC1 cytidine and dCMP deaminase domain containing 1 2.17648
OR2W1 olfactory receptor, family 2, subfamily W, member 1 2.17502
CCDC70 coiled-coil domain containing 70 2.17466
ERN1 endoplasmic reticulum to nucleus signaling 1 2.1744
LOC124900193 uncharacterized LOC124900193 2.1738
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.17227
PRDM16 PR domain containing 16 2.17197
TLX2 T-cell leukemia homeobox 2 2.17139
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.16876
OCM2 oncomodulin 2 2.16849
ZFP91 ZFP91 zinc finger protein 2.16611
SPATA31C1 SPATA31 subfamily C, member 1 2.16557
WNT1 wingless-type MMTV integration site family, member 1 2.16421
RXFP3 relaxin/insulin-like family peptide receptor 3 2.1624
METTL16 methyltransferase like 16 2.15971
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.15838
THAP9 THAP domain containing 9 2.15747
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 2.15728
RAD21L1 RAD21-like 1 (S. pombe) 2.15699
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.15616
MED31 mediator complex subunit 31 2.15455
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.15338
AGBL3 ATP/GTP binding protein-like 3 2.15329
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 2.15207
HYOU1 hypoxia up-regulated 1 2.15174
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 2.15172
ZNF81 zinc finger protein 81 2.14753
TULP2 tubby like protein 2 2.14702
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.14399
CATSPERZ catsper channel auxiliary subunit zeta 2.14247
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.14151
RAB40A RAB40A, member RAS oncogene family 2.14052
OTUD7B OTU deubiquitinase 7B 2.13964
ACOXL acyl-CoA oxidase-like 2.13938
DNASE1 deoxyribonuclease I 2.13919
CRYBA2 crystallin, beta A2 2.13763
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.13749
GBX2 gastrulation brain homeobox 2 2.13682
LOC102723996 ICOS ligand 2.13542
ZNF675 zinc finger protein 675 2.13401
IFNA8 interferon, alpha 8 2.13357
GJA9 gap junction protein, alpha 9, 59kDa 2.13306
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 2.1305
ANKRD7 ankyrin repeat domain 7 2.13029
ZNF154 zinc finger protein 154 2.12818
TLL1 tolloid-like 1 2.12697
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.12513
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.12505
PMFBP1 polyamine modulated factor 1 binding protein 1 2.12502
GPR32 G protein-coupled receptor 32 2.12453
CDH9 cadherin 9, type 2 (T1-cadherin) 2.12446
SOX30 SRY (sex determining region Y)-box 30 2.1244
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.12425
MMP27 matrix metallopeptidase 27 2.12373
NPAS1 neuronal PAS domain protein 1 2.12262
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.12132
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.12111
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.11881
PCDHB8 protocadherin beta 8 2.11867
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.11826
CRYBA4 crystallin, beta A4 2.1174
CDH20 cadherin 20, type 2 2.11616
GJA3 gap junction protein, alpha 3, 46kDa 2.11561
PLSCR2 phospholipid scramblase 2 2.11503
GPR173 G protein-coupled receptor 173 2.11375
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.11261
HCRT hypocretin (orexin) neuropeptide precursor 2.11195
TNP1 transition protein 1 (during histone to protamine replacement) 2.11117
POU1F1 POU class 1 homeobox 1 2.10989
CHD6 chromodomain helicase DNA binding protein 6 2.1034
LMX1B LIM homeobox transcription factor 1, beta 2.10234
PSPN persephin 2.10213
OVOL3 ovo-like zinc finger 3 2.10185
ARHGAP11A Rho GTPase activating protein 11A 2.10157
NTN1 netrin 1 2.10141
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.09788
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.09773
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.09595
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.09571
PKD2L2 polycystic kidney disease 2-like 2 2.09433
ADAM18 ADAM metallopeptidase domain 18 2.09385
LRRC3 leucine rich repeat containing 3 2.09206
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.08992
TRHR thyrotropin-releasing hormone receptor 2.08702
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.08231
EMC10 ER membrane protein complex subunit 10 2.08227
VENTX VENT homeobox 2.08146
GRM2 glutamate receptor, metabotropic 2 2.07893
SSX5 synovial sarcoma, X breakpoint 5 2.07885
LAMB4 laminin, beta 4 2.07883
ANGPTL8 angiopoietin like 8 2.07819
BRDT bromodomain, testis-specific 2.07742
PRM2 protamine 2 2.07642
AIG1 androgen-induced 1 2.07578
CCR3 chemokine (C-C motif) receptor 3 2.07467
MYH15 myosin, heavy chain 15 2.0744
CENPQ centromere protein Q 2.07144
PLA2G2E phospholipase A2, group IIE 2.07133
TREML2 triggering receptor expressed on myeloid cells-like 2 2.06977
FNDC11 fibronectin type III domain containing 11 2.06861
IL12RB1 interleukin 12 receptor, beta 1 2.06751
VPS50 VPS50 subunit of EARP/GARPII complex 2.06751
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 2.0661
OPN1MW3 opsin 1, medium wave sensitive 3 2.0661
FOXL1 forkhead box L1 2.06604
BEND5 BEN domain containing 5 2.06245
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.06243
CCDC33 coiled-coil domain containing 33 2.061
PDE12 phosphodiesterase 12 2.06057
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.05914
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.05785
ADM2 adrenomedullin 2 2.05708
HOXB8 homeobox B8 2.05681
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.05625
ADGB androglobin 2.05476
DNAH17 dynein, axonemal, heavy chain 17 2.05437
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 2.05405
NOX3 NADPH oxidase 3 2.05199
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.0516
NR2E3 nuclear receptor subfamily 2, group E, member 3 2.04932
PRDM11 PR domain containing 11 2.04875
FSHR follicle stimulating hormone receptor 2.04841
GCM2 glial cells missing homolog 2 (Drosophila) 2.04803
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.04753
KLHL11 kelch-like family member 11 2.04694
GJA5 gap junction protein, alpha 5, 40kDa 2.04659
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 2.04492
IMPG1 interphotoreceptor matrix proteoglycan 1 2.04318
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.03954
MAPK4 mitogen-activated protein kinase 4 2.03917
SPACA1 sperm acrosome associated 1 2.0379
FGF16 fibroblast growth factor 16 2.03709
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 2.03679
ZNF132 zinc finger protein 132 2.03576
PURG purine-rich element binding protein G 2.03503
S100A5 S100 calcium binding protein A5 2.033
TACR3 tachykinin receptor 3 2.03242
MLNR motilin receptor 2.03193
KIAA1549L KIAA1549-like 2.03004
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.02979
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 2.02953
PAX4 paired box 4 2.02871
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.02838
FZD8 frizzled class receptor 8 2.02811
ADRA1A adrenoceptor alpha 1A 2.02644
COL19A1 collagen, type XIX, alpha 1 2.02523
PAPOLB poly(A) polymerase beta (testis specific) 2.0247
CMA1 chymase 1, mast cell 2.02447
CCKAR cholecystokinin A receptor 2.02417
TAS2R3 taste receptor, type 2, member 3 2.02353
H2BC15 H2B clustered histone 15 2.02352
ZNF749 zinc finger protein 749 2.02293
GLRA3 glycine receptor, alpha 3 2.02125
SPO11 SPO11 meiotic protein covalently bound to DSB 2.02099
SCT secretin 2.01793
EMX1 empty spiracles homeobox 1 2.01504
KISS1 KiSS-1 metastasis-suppressor 2.01444
OPRD1 opioid receptor, delta 1 2.0142
ZBTB7B zinc finger and BTB domain containing 7B 2.01401
GHSR growth hormone secretagogue receptor 2.01352
CLDN17 claudin 17 2.01285
GDF10 growth differentiation factor 10 2.01141
TAS2R13 taste receptor, type 2, member 13 2.01082
OR2F2 olfactory receptor, family 2, subfamily F, member 2 2.00935
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.00868
SLC25A30 solute carrier family 25, member 30 2.00856
NRDE2 NRDE-2, necessary for RNA interference, domain containing 2.0077
ADCY10 adenylate cyclase 10 (soluble) 2.0053
TSPAN2 tetraspanin 2 2.0048
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 2.00372
CCIN calicin 2.00318
RASL10A RAS-like, family 10, member A 2.00241
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.00161
PYGO1 pygopus family PHD finger 1 2.00153

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -4.44156
KRT14 keratin 14, type I -4.03876
REXO2 RNA exonuclease 2 -2.80019
DUSP14 dual specificity phosphatase 14 -2.27228
TAC4 tachykinin 4 (hemokinin) -2.18529
NLRP4 NLR family, pyrin domain containing 4 -2.17875
PCNA proliferating cell nuclear antigen -2.11649
PSRC1 proline/serine-rich coiled-coil 1 -2.00323