CRCGN017_MCF10A.TP53.M_24H:P01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-naphthylamine 102.67 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

139 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LGMN legumain 5.4786
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.40315
GPER1 G protein-coupled estrogen receptor 1 4.39937
CNRIP1 cannabinoid receptor interacting protein 1 4.1427
ADRB2 adrenoceptor beta 2, surface 3.87745
WFS1 Wolfram syndrome 1 (wolframin) 3.4014
ACAA1 acetyl-CoA acyltransferase 1 3.35795
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 3.02265
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 3.0157
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.00548
CAPN1 calpain 1, (mu/I) large subunit 2.9801
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.9336
KLK11 kallikrein-related peptidase 11 2.88625
ASRGL1 asparaginase like 1 2.7883
LYN LYN proto-oncogene, Src family tyrosine kinase 2.78743
PLA2G15 phospholipase A2, group XV 2.76405
HLA-DMA major histocompatibility complex, class II, DM alpha 2.7358
GOLGA8F golgin A8 family, member F 2.63025
SCAMP4 secretory carrier membrane protein 4 2.58495
DENND2D DENN/MADD domain containing 2D 2.58465
C5 complement component 5 2.5824
ABLIM3 actin binding LIM protein family, member 3 2.5607
CEP164 centrosomal protein 164kDa 2.52082
CHIA chitinase, acidic 2.51745
ENDOU endonuclease, polyU-specific 2.5027
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.4535
DIO2 deiodinase, iodothyronine, type II 2.43027
MUC1 mucin 1, cell surface associated 2.37947
VAV3 vav 3 guanine nucleotide exchange factor 2.36665
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.34305
MYLIP myosin regulatory light chain interacting protein 2.33935
PLXND1 plexin D1 2.3316
EPN2 epsin 2 2.32868
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.3173
AACS acetoacetyl-CoA synthetase 2.29785
CDH22 cadherin 22, type 2 2.28545
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.2769
CASQ2 calsequestrin 2 (cardiac muscle) 2.2688
USP6NL USP6 N-terminal like 2.2616
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 2.24685
KLK12 kallikrein-related peptidase 12 2.23225
SPINK5 serine peptidase inhibitor, Kazal type 5 2.22835
CLASRP CLK4-associating serine/arginine rich protein 2.2245
RHEX regulator of hemoglobinization and erythroid cell expansion 2.22088
H2AJ H2A.J histone 2.21495
PGR progesterone receptor 2.2023
AOC1 amine oxidase, copper containing 1 2.19605
EI24 etoposide induced 2.4 2.18055
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 2.17995
APOE apolipoprotein E 2.17252
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.16085
ECHDC2 enoyl CoA hydratase domain containing 2 2.158
PLAG1 pleiomorphic adenoma gene 1 2.1566
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.15145
CNTN2 contactin 2 (axonal) 2.13635
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.13585
GRM3 glutamate receptor, metabotropic 3 2.11925
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.1101
EXT1 exostosin glycosyltransferase 1 2.10675
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.10615
MITF microphthalmia-associated transcription factor 2.103
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.10065
SOBP sine oculis binding protein homolog (Drosophila) 2.10005
FRMD4B FERM domain containing 4B 2.09525
GTPBP6 GTP binding protein 6 (putative) 2.0943
COG4 component of oligomeric golgi complex 4 2.08745
POM121L2 POM121 transmembrane nucleoporin-like 2 2.08115
PILRB paired immunoglobin-like type 2 receptor beta 2.08105
ZNF692 zinc finger protein 692 2.07765
CPM carboxypeptidase M 2.07645
MCF2L MCF.2 cell line derived transforming sequence-like 2.06227
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.06215
NALF1 NALCN channel auxiliary factor 1 2.06205
TMOD1 tropomodulin 1 2.06115
DEPTOR DEP domain containing MTOR-interacting protein 2.0543
STX18 syntaxin 18 2.0501
EDAR ectodysplasin A receptor 2.04925
TNS2 tensin 2 2.0467
MMP1 matrix metallopeptidase 1 2.04273
ARHGAP9 Rho GTPase activating protein 9 2.041
GTPBP8 GTP-binding protein 8 (putative) 2.03925
SNAP91 synaptosomal-associated protein, 91kDa 2.037
TGM3 transglutaminase 3 2.0331
RASIP1 Ras interacting protein 1 2.0318
SNTA1 syntrophin, alpha 1 2.02685
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.01958
STAT5A signal transducer and activator of transcription 5A 2.01785
LPAR2 lysophosphatidic acid receptor 2 2.00982
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.00975
SLC22A14 solute carrier family 22, member 14 2.0052
EMP2 epithelial membrane protein 2 2.00455
VSIG10 V-set and immunoglobulin domain containing 10 2.00315

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.57015
CCNB1 cyclin B1 -4.75535
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.85223
KIF23 kinesin family member 23 -3.19055
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -2.9693
RAI14 retinoic acid induced 14 -2.74845
FZD7 frizzled class receptor 7 -2.6369
NGRN neugrin, neurite outgrowth associated -2.5871
ZNF274 zinc finger protein 274 -2.58645
CANT1 calcium activated nucleotidase 1 -2.57232
DCTD dCMP deaminase -2.56532
EXO1 exonuclease 1 -2.4674
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.41495
ECT2 epithelial cell transforming 2 -2.4086
RAD17 RAD17 homolog (S. pombe) -2.40745
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.407
RGS2 regulator of G-protein signaling 2 -2.356
CDK4 cyclin-dependent kinase 4 -2.3255
ERCC6L excision repair cross-complementation group 6-like -2.3034
MACF1 microtubule-actin crosslinking factor 1 -2.30046
KRT14 keratin 14, type I -2.3
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.29945
MOCS2 molybdenum cofactor synthesis 2 -2.2954
ACTA2 actin, alpha 2, smooth muscle, aorta -2.29515
SKA1 spindle and kinetochore associated complex subunit 1 -2.29165
LPO lactoperoxidase -2.2887
CYREN cell cycle regulator of NHEJ -2.28455
PEX19 peroxisomal biogenesis factor 19 -2.24363
AK6 adenylate kinase 6 -2.23045
KIF18A kinesin family member 18A -2.1876
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.1825
IL2RG interleukin 2 receptor, gamma -2.1803
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.17185
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.17072
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.16385
AMZ2 archaelysin family metallopeptidase 2 -2.16385
F2RL1 coagulation factor II (thrombin) receptor-like 1 -2.12488
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.1041
FBXO5 F-box protein 5 -2.0996
KNTC1 kinetochore associated 1 -2.09445
SMC1A structural maintenance of chromosomes 1A -2.09052
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.07335
FBXO28 F-box protein 28 -2.069
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.05685
NELFE negative elongation factor complex member E -2.0178
CLDND1 claudin domain containing 1 -2.01185
CERS2 ceramide synthase 2 -2.00765