CRCGN017_MCF10A.TP53.M_24H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-naphthylamine 11.41 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 4.06456
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.87038
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.69348
BMP4 bone morphogenetic protein 4 3.557
LYN LYN proto-oncogene, Src family tyrosine kinase 3.48403
LGMN legumain 3.35862
ABHD4 abhydrolase domain containing 4 3.35071
ZNF589 zinc finger protein 589 2.9667
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.9648
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.88146
EPN2 epsin 2 2.82327
CNPY3 canopy FGF signaling regulator 3 2.80127
MMP1 matrix metallopeptidase 1 2.77893
VAV3 vav 3 guanine nucleotide exchange factor 2.77706
C5 complement component 5 2.70472
MRNIP MRN complex interacting protein 2.65747
COMP cartilage oligomeric matrix protein 2.60354
ELOVL6 ELOVL fatty acid elongase 6 2.47244
TERT telomerase reverse transcriptase 2.46967
GHR growth hormone receptor 2.42706
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.41359
SMNDC1 survival motor neuron domain containing 1 2.37104
ZNF669 zinc finger protein 669 2.32515
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.31955
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.28932
PLXNB1 plexin B1 2.2721
NCKIPSD NCK interacting protein with SH3 domain 2.26466
MZF1 myeloid zinc finger 1 2.22062
CNTN2 contactin 2 (axonal) 2.20501
SINHCAF SIN3-HDAC complex associated factor 2.16908
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.16054
RAB31 RAB31, member RAS oncogene family 2.15645
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.15333
DPP6 dipeptidyl-peptidase 6 2.14709
COPS7B COP9 signalosome subunit 7B 2.09226
MPC2 mitochondrial pyruvate carrier 2 2.08321
SLC75A1 solute carrier family 75 member 1 2.08258
SPDEF SAM pointed domain containing ETS transcription factor 2.08176
FAM193B family with sequence similarity 193, member B 2.07304
DENND1B DENN/MADD domain containing 1B 2.04101
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.03748
IFT140 intraflagellar transport 140 2.00602

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.42438
CDK4 cyclin-dependent kinase 4 -3.79394
KRT14 keratin 14, type I -3.77691
GRWD1 glutamate-rich WD repeat containing 1 -3.0392
TRAPPC3 trafficking protein particle complex 3 -2.94637
HMG20B high mobility group 20B -2.80962
NGRN neugrin, neurite outgrowth associated -2.76006
LAGE3 L antigen family, member 3 -2.73324
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.4429
THAP11 THAP domain containing 11 -2.37662
VAT1 vesicle amine transport 1 -2.22739
MSN moesin -2.17778
ACOD1 aconitate decarboxylase 1 -2.15533
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.14631
SEC16A SEC16 homolog A (S. cerevisiae) -2.13913
NUP93 nucleoporin 93kDa -2.082
PRMT5 protein arginine methyltransferase 5 -2.04733
STX1A syntaxin 1A (brain) -2.04357
TATDN2 TatD DNase domain containing 2 -2.03191
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.01512
FKBP11 FK506 binding protein 11, 19 kDa -2.00044