CRCGN017_MCF10A.TP53.M_24H:P04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description reserpine 101.21 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

225 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.19588
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.1466
PRAF2 PRA1 domain family, member 2 4.12353
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.01749
SQSTM1 sequestosome 1 3.98021
AGR2 anterior gradient 2 3.85135
LSR lipolysis stimulated lipoprotein receptor 3.74768
TMEM109 transmembrane protein 109 3.72602
ZNF586 zinc finger protein 586 3.55168
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.54035
TRIB3 tribbles pseudokinase 3 3.51456
PYCR1 pyrroline-5-carboxylate reductase 1 3.49286
INSIG1 insulin induced gene 1 3.44136
ECH1 enoyl CoA hydratase 1, peroxisomal 3.06138
HMOX1 heme oxygenase 1 3.04625
SPDEF SAM pointed domain containing ETS transcription factor 3.00724
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.95918
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.93368
GATA3 GATA binding protein 3 2.92993
GARS1 glycyl-tRNA synthetase 1 2.90326
ALDOC aldolase C, fructose-bisphosphate 2.89943
PHGDH phosphoglycerate dehydrogenase 2.74378
RRAGC Ras-related GTP binding C 2.73333
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.70052
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.61363
LGMN legumain 2.54816
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.54097
RSF1 remodeling and spacing factor 1 2.53958
SH3D19 SH3 domain containing 19 2.52053
CLCN6 chloride channel, voltage-sensitive 6 2.5149
MACO1 macoilin 1 2.48853
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.47766
APOE apolipoprotein E 2.41836
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.40162
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 2.38962
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.34814
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.34304
ATF4 activating transcription factor 4 2.33696
TSHR thyroid stimulating hormone receptor 2.33246
MMP1 matrix metallopeptidase 1 2.3286
CARS1 cysteinyl-tRNA synthetase 1 2.32041
TCTN1 tectonic family member 1 2.31422
PSENEN presenilin enhancer gamma secretase subunit 2.29016
TMEM39A transmembrane protein 39A 2.28348
NUCB2 nucleobindin 2 2.27777
UVRAG UV radiation resistance associated 2.26729
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 2.2614
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.22606
SLC75A1 solute carrier family 75 member 1 2.21636
CADM1 cell adhesion molecule 1 2.21017
LYN LYN proto-oncogene, Src family tyrosine kinase 2.20734
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.19931
VSIG2 V-set and immunoglobulin domain containing 2 2.19438
TG thyroglobulin 2.1939
TIMP2 TIMP metallopeptidase inhibitor 2 2.18731
MAP3K12 mitogen-activated protein kinase kinase kinase 12 2.18138
TCEA2 transcription elongation factor A (SII), 2 2.18007
TFF1 trefoil factor 1 2.17081
DHCR7 7-dehydrocholesterol reductase 2.16774
RPN1 ribophorin I 2.1585
PLPP2 phospholipid phosphatase 2 2.15256
ELMO3 engulfment and cell motility 3 2.14574
MLPH melanophilin 2.14287
SNAP25 synaptosomal-associated protein, 25kDa 2.13974
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.1385
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.13314
HYOU1 hypoxia up-regulated 1 2.12613
MAP9 microtubule-associated protein 9 2.12213
STIMATE STIM activating enhancer 2.11383
ORAI2 ORAI calcium release-activated calcium modulator 2 2.11286
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.11269
HLA-DMB major histocompatibility complex, class II, DM beta 2.10815
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.09142
DDIT4 DNA-damage-inducible transcript 4 2.08906
MANBA mannosidase, beta A, lysosomal 2.07766
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 2.05269
SALL1 spalt-like transcription factor 1 2.05133
CUTA cutA divalent cation tolerance homolog (E. coli) 2.04193
PNPLA3 patatin-like phospholipase domain containing 3 2.04165
LOC128125814 uncharacterized LOC128125814 2.03071
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.02344
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.02124
SH2B2 SH2B adaptor protein 2 2.02066
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.01187
ZC2HC1A zinc finger, C2HC-type containing 1A 2.00392
CREB3L4 cAMP responsive element binding protein 3-like 4 2.00298
FADS2 fatty acid desaturase 2 2.00063

decreased expression

Symbol Name Standardized Value
DCK deoxycytidine kinase -5.57121
ADI1 acireductone dioxygenase 1 -5.21861
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.06887
STMN1 stathmin 1 -4.86677
UBE2C ubiquitin-conjugating enzyme E2C -4.10533
ADRB2 adrenoceptor beta 2, surface -4.0697
AURKA aurora kinase A -3.67445
NLRP2B NLR family pyrin domain containing 2B -3.38911
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.34938
C1QBP complement component 1, q subcomponent binding protein -3.30641
MAPK13 mitogen-activated protein kinase 13 -3.25631
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.22534
GRWD1 glutamate-rich WD repeat containing 1 -3.2176
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.10064
KIF14 kinesin family member 14 -3.09583
CCNA2 cyclin A2 -3.05987
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.05892
RFC2 replication factor C (activator 1) 2, 40kDa -3.04724
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.02966
HDAC2 histone deacetylase 2 -2.94952
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.89005
MRPL12 mitochondrial ribosomal protein L12 -2.88128
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.83344
HAT1 histone acetyltransferase 1 -2.82737
CDK1 cyclin-dependent kinase 1 -2.81481
ZNF274 zinc finger protein 274 -2.80192
AURKB aurora kinase B -2.77487
NUP85 nucleoporin 85kDa -2.75923
KIF20A kinesin family member 20A -2.75467
BIRC5 baculoviral IAP repeat containing 5 -2.75309
MCM10 minichromosome maintenance complex component 10 -2.73245
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.69674
PSIP1 PC4 and SFRS1 interacting protein 1 -2.67284
BMAL2 basic helix-loop-helix ARNT like 2 -2.66465
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.64083
RHCG Rh family, C glycoprotein -2.63512
CENPA centromere protein A -2.62859
RBM14-RBM4 RBM14-RBM4 readthrough -2.61902
IGFBP7 insulin-like growth factor binding protein 7 -2.60707
CYCS cytochrome c, somatic -2.5885
HJURP Holliday junction recognition protein -2.56808
FOXM1 forkhead box M1 -2.55892
IVL involucrin -2.54308
HSPA4L heat shock 70kDa protein 4-like -2.54056
SNRPC small nuclear ribonucleoprotein polypeptide C -2.53338
CDCA3 cell division cycle associated 3 -2.51433
KLK8 kallikrein-related peptidase 8 -2.50248
HMGB2 high mobility group box 2 -2.50088
KIF23 kinesin family member 23 -2.48991
GTF2A2 general transcription factor IIA, 2, 12kDa -2.48281
CDC6 cell division cycle 6 -2.47391
RPP30 ribonuclease P/MRP 30kDa subunit -2.45797
VRK1 vaccinia related kinase 1 -2.45147
NCAPG2 non-SMC condensin II complex, subunit G2 -2.4412
DSN1 DSN1, MIS12 kinetochore complex component -2.42593
CDCA8 cell division cycle associated 8 -2.40991
KIF11 kinesin family member 11 -2.40507
NUP54 nucleoporin 54kDa -2.40404
THAP11 THAP domain containing 11 -2.40326
TRIP13 thyroid hormone receptor interactor 13 -2.39476
HOPX HOP homeobox -2.39282
TACC3 transforming, acidic coiled-coil containing protein 3 -2.38535
KIF4A kinesin family member 4A -2.37218
SPDL1 spindle apparatus coiled-coil protein 1 -2.36612
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.3626
PSRC1 proline/serine-rich coiled-coil 1 -2.35536
MRPS2 mitochondrial ribosomal protein S2 -2.32884
SHCBP1 SHC SH2-domain binding protein 1 -2.3214
MSH2 mutS homolog 2 -2.31611
TTK TTK protein kinase -2.30676
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -2.29989
CKAP2 cytoskeleton associated protein 2 -2.29667
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.29396
COQ3 coenzyme Q3 methyltransferase -2.29218
RACGAP1 Rac GTPase activating protein 1 -2.27389
NPR2 natriuretic peptide receptor 2 -2.27311
TUBB4B tubulin, beta 4B class IVb -2.27302
FXN frataxin -2.26683
PCCB propionyl CoA carboxylase, beta polypeptide -2.25768
RPA3 replication protein A3, 14kDa -2.25556
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.25256
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -2.25256
SMAGP small cell adhesion glycoprotein -2.25138
ASF1B anti-silencing function 1B histone chaperone -2.2502
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.24632
SPC25 SPC25, NDC80 kinetochore complex component -2.2445
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.24089
CDCA4 cell division cycle associated 4 -2.22977
MCM5 minichromosome maintenance complex component 5 -2.20571
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.20036
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.19443
CCNB2 cyclin B2 -2.18691
DEK DEK proto-oncogene -2.18678
CDC45 cell division cycle 45 -2.18386
RPP40 ribonuclease P/MRP 40kDa subunit -2.1793
GNG10 guanine nucleotide binding protein (G protein), gamma 10 -2.17826
LOC128966597 MAL-like protein -2.17765
DCTD dCMP deaminase -2.17015
CDC20 cell division cycle 20 -2.16941
KIF15 kinesin family member 15 -2.16234
NUP205 nucleoporin 205kDa -2.15814
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -2.15521
SPRR1A small proline-rich protein 1A -2.14559
PRKCH protein kinase C, eta -2.13103
DBR1 debranching RNA lariats 1 -2.13061
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -2.12989
MRPL42 mitochondrial ribosomal protein L42 -2.12734
KDM1A lysine (K)-specific demethylase 1A -2.12479
MRPS7 mitochondrial ribosomal protein S7 -2.12393
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.10927
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.09909
NAT10 N-acetyltransferase 10 (GCN5-related) -2.09835
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.09482
KCTD9 potassium channel tetramerization domain containing 9 -2.09435
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.09051
GLRX5 glutaredoxin 5 -2.08696
GLO1 glyoxalase I -2.08568
TSPAN6 tetraspanin 6 -2.08329
CHMP6 charged multivesicular body protein 6 -2.08077
ANGPTL7 angiopoietin-like 7 -2.07638
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -2.07545
TPX2 TPX2, microtubule-associated -2.07504
DEPDC1 DEP domain containing 1 -2.07341
BZW2 basic leucine zipper and W2 domains 2 -2.07239
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.06831
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.068
MLF1 myeloid leukemia factor 1 -2.05343
TXNDC9 thioredoxin domain containing 9 -2.05251
POLR1G RNA polymerase I subunit G -2.04955
PARP2 poly (ADP-ribose) polymerase 2 -2.04642
PBK PDZ binding kinase -2.04123
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.03404
PHB1 prohibitin 1 -2.02993
CREB1 cAMP responsive element binding protein 1 -2.01295
ERCC6L excision repair cross-complementation group 6-like -2.00622
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.00609
PLK1 polo-like kinase 1 -2.00133
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.00129