CRCGN017_MCF10A.TP53.M_24H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-anisidine.hcl 100.48 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.9715
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.69434
KDM5D lysine (K)-specific demethylase 5D 3.6164
CCP110 centriolar coiled coil protein 110kDa 3.55948
CCDC92 coiled-coil domain containing 92 3.48795
MPC2 mitochondrial pyruvate carrier 2 3.27438
RAB21 RAB21, member RAS oncogene family 3.0244
KDM5A lysine (K)-specific demethylase 5A 2.98539
ZNF589 zinc finger protein 589 2.96693
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.92282
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.84678
LAP3 leucine aminopeptidase 3 2.76937
WIF1 WNT inhibitory factor 1 2.71406
USP9Y ubiquitin specific peptidase 9, Y-linked 2.47627
CERK ceramide kinase 2.4728
DRAM1 DNA-damage regulated autophagy modulator 1 2.46212
SYNE2 spectrin repeat containing, nuclear envelope 2 2.43648
CGRRF1 cell growth regulator with ring finger domain 1 2.37634
MYL9 myosin, light chain 9, regulatory 2.36087
H2BC9 H2B clustered histone 9 2.35175
CCNF cyclin F 2.3319
ADRB2 adrenoceptor beta 2, surface 2.31618
SNAP29 synaptosomal-associated protein, 29kDa 2.29648
TBC1D31 TBC1 domain family, member 31 2.2648
PEX11A peroxisomal biogenesis factor 11 alpha 2.23081
CCNH cyclin H 2.23005
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.22285
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.22129
PRR7 proline rich 7 (synaptic) 2.20481
NUCB2 nucleobindin 2 2.18401
DPP4 dipeptidyl-peptidase 4 2.15229
PEX5 peroxisomal biogenesis factor 5 2.12065
HLA-DRA major histocompatibility complex, class II, DR alpha 2.11169
CHN1 chimerin 1 2.10909
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.10096
ATXN2 ataxin 2 2.04775
CADM1 cell adhesion molecule 1 2.04742
CCDC25 coiled-coil domain containing 25 2.03732
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.0295
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.01705
HIRA histone cell cycle regulator 2.0058
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.00111

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.94924
TES testin LIM domain protein -4.79793
MSN moesin -4.5854
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.32059
LIMS2 LIM and senescent cell antigen-like domains 2 -2.84546
SMC1A structural maintenance of chromosomes 1A -2.82266
COTL1 coactosin-like F-actin binding protein 1 -2.74825
DCTD dCMP deaminase -2.67851
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.61115
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.59972
PUDP pseudouridine 5'-phosphatase -2.58825
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.47623
ALX1 ALX homeobox 1 -2.47382
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.39586
GRWD1 glutamate-rich WD repeat containing 1 -2.3769
PSRC1 proline/serine-rich coiled-coil 1 -2.28705
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.20132
KDM5C lysine (K)-specific demethylase 5C -2.19784
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.13924
TOP2B topoisomerase (DNA) II beta 180kDa -2.11389
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.11177
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.06093
WASF2 WAS protein family, member 2 -2.0598
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.05797
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.0576
URGCP upregulator of cell proliferation -2.05543
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.0382
MIA melanoma inhibitory activity -2.02713