CRCGN017_MCF10A.TP53.M_24H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-anisidine.hcl 33.49 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

252 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 9.69794
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.5993
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.27784
KLHL21 kelch-like family member 21 4.76095
CNPY3 canopy FGF signaling regulator 3 4.72625
ACTG2 actin, gamma 2, smooth muscle, enteric 4.19427
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 3.92973
TGFB3 transforming growth factor, beta 3 3.87143
MYH11 myosin, heavy chain 11, smooth muscle 3.48592
CNN1 calponin 1, basic, smooth muscle 3.48147
WIF1 WNT inhibitory factor 1 3.4728
FOS FBJ murine osteosarcoma viral oncogene homolog 3.42378
PTGDS prostaglandin D2 synthase 21kDa (brain) 3.4159
CD48 CD48 molecule 3.16309
LRRC47 leucine rich repeat containing 47 3.13343
CP ceruloplasmin (ferroxidase) 3.05801
PLAAT4 phospholipase A and acyltransferase 4 3.0361
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.99697
KLHDC2 kelch domain containing 2 2.98441
ACAA1 acetyl-CoA acyltransferase 1 2.91804
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 2.90107
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.89414
CNPY3-GNMT CNPY3-GNMT readthrough 2.88373
PVRIG poliovirus receptor related immunoglobulin domain containing 2.83149
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.82061
UGDH UDP-glucose 6-dehydrogenase 2.79944
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.79382
RIN2 Ras and Rab interactor 2 2.77203
ACKR5 atypical chemokine receptor 5 2.7683
ADAMTSL3 ADAMTS-like 3 2.7455
PLA2G2D phospholipase A2, group IID 2.74119
C4A complement component 4A (Rodgers blood group) 2.72095
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.71289
OR7C2 olfactory receptor, family 7, subfamily C, member 2 2.68542
H2AZ2 H2A.Z variant histone 2 2.66968
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.65415
NOSIP nitric oxide synthase interacting protein 2.64471
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.63118
C3AR1 complement component 3a receptor 1 2.62973
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.62283
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.59366
COL11A1 collagen, type XI, alpha 1 2.59056
WNT16 wingless-type MMTV integration site family, member 16 2.58085
CCR8 chemokine (C-C motif) receptor 8 2.56072
PODNL1 podocan-like 1 2.54813
CXCR6 chemokine (C-X-C motif) receptor 6 2.5424
BLNK B-cell linker 2.53572
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.53134
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.52627
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.52503
GPRC5C G protein-coupled receptor, class C, group 5, member C 2.51856
TLR5 toll-like receptor 5 2.51747
ACP3 acid phosphatase 3 2.51674
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.5161
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.51279
IDO1 indoleamine 2,3-dioxygenase 1 2.50111
PLN phospholamban 2.49487
CXCL9 chemokine (C-X-C motif) ligand 9 2.45438
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.45293
GZMK granzyme K (granzyme 3; tryptase II) 2.44547
SARAF store-operated calcium entry-associated regulatory factor 2.44275
SLAMF8 SLAM family member 8 2.4415
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.43647
DGCR2 DiGeorge syndrome critical region gene 2 2.42036
MAOB monoamine oxidase B 2.41567
KHDC1L KH homology domain containing 1-like 2.40022
CLEC7A C-type lectin domain family 7, member A 2.39894
ACTA2 actin, alpha 2, smooth muscle, aorta 2.39067
RORC RAR-related orphan receptor C 2.38688
ZNF395 zinc finger protein 395 2.38668
TLR3 toll-like receptor 3 2.37985
ELSPBP1 epididymal sperm binding protein 1 2.37435
TAGLN transgelin 2.37181
EDNRA endothelin receptor type A 2.35711
CD8A CD8a molecule 2.35532
MMP2 matrix metallopeptidase 2 2.35354
CERK ceramide kinase 2.35109
CMKLR1 chemerin chemokine-like receptor 1 2.33219
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.32559
CNTN2 contactin 2 (axonal) 2.31999
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 2.31711
NNMT nicotinamide N-methyltransferase 2.31691
COL8A2 collagen, type VIII, alpha 2 2.31483
IGSF6 immunoglobulin superfamily, member 6 2.3143
PEX14 peroxisomal biogenesis factor 14 2.28382
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.27903
CXXC4 CXXC finger protein 4 2.27817
HLA-DMB major histocompatibility complex, class II, DM beta 2.27335
PKD2L1 polycystic kidney disease 2-like 1 2.27262
CXCL13 chemokine (C-X-C motif) ligand 13 2.26257
CD2 CD2 molecule 2.26021
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.25973
SUSD4 sushi domain containing 4 2.25594
DES desmin 2.25304
SLC35E3 solute carrier family 35, member E3 2.24897
MILR1 mast cell immunoglobulin-like receptor 1 2.24182
RAB21 RAB21, member RAS oncogene family 2.23576
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.23155
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.22753
PTN pleiotrophin 2.22153
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.22091
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.21929
MSMB microseminoprotein, beta- 2.21749
NUPR1 nuclear protein, transcriptional regulator, 1 2.20528
C3 complement component 3 2.20491
CD72 CD72 molecule 2.20307
KREMEN2 kringle containing transmembrane protein 2 2.20169
TBC1D2 TBC1 domain family, member 2 2.20068
MYL9 myosin, light chain 9, regulatory 2.19709
CIAO3 cytosolic iron-sulfur assembly component 3 2.19362
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.19287
C5 complement component 5 2.1897
MXD3 MAX dimerization protein 3 2.18946
MPC2 mitochondrial pyruvate carrier 2 2.18693
CA7 carbonic anhydrase VII 2.18449
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.18032
PID1 phosphotyrosine interaction domain containing 1 2.18012
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.17643
PDGFC platelet derived growth factor C 2.17611
DENND2D DENN/MADD domain containing 2D 2.17376
ZFPM2 zinc finger protein, FOG family member 2 2.17013
FGD2 FYVE, RhoGEF and PH domain containing 2 2.16749
RAB40C RAB40C, member RAS oncogene family 2.16597
MUC4 mucin 4, cell surface associated 2.16535
CFAP74 cilia and flagella associated protein 74 2.16503
FDX1 ferredoxin 1 2.16454
LDLRAD4 low density lipoprotein receptor class A domain containing 4 2.16064
GNLY granulysin 2.15959
CCDC87 coiled-coil domain containing 87 2.15671
COL10A1 collagen, type X, alpha 1 2.15595
CASD1 CAS1 domain containing 1 2.15337
VTCN1 V-set domain containing T cell activation inhibitor 1 2.15038
GPR65 G protein-coupled receptor 65 2.14936
RGCC regulator of cell cycle 2.14858
TBPL1 TBP-like 1 2.14826
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.13975
NCAN neurocan 2.1376
ANAPC2 anaphase promoting complex subunit 2 2.11136
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.11088
ORM2 orosomucoid 2 2.1015
MPO myeloperoxidase 2.10143
CXCL11 chemokine (C-X-C motif) ligand 11 2.09888
MMP9 matrix metallopeptidase 9 2.09807
TMEM94 transmembrane protein 94 2.09351
PPOX protoporphyrinogen oxidase 2.09245
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.08992
TMEM212 transmembrane protein 212 2.08785
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.08687
RAB20 RAB20, member RAS oncogene family 2.08552
SDF4 stromal cell derived factor 4 2.08426
GPR21 G protein-coupled receptor 21 2.08319
EGLN3 egl-9 family hypoxia-inducible factor 3 2.08055
DMXL2 Dmx-like 2 2.07689
CLXN calaxin 2.07637
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.07531
CXCL10 chemokine (C-X-C motif) ligand 10 2.07512
GRK3 G protein-coupled receptor kinase 3 2.06819
LOC128966570 alpha-amylase 1B 2.06403
DOCK4 dedicator of cytokinesis 4 2.0609
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.05938
LMAN1L lectin, mannose-binding, 1 like 2.05901
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.05742
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.05627
MEIS2 Meis homeobox 2 2.05594
SH3BGRL SH3 domain binding glutamate-rich protein like 2.05175
NUAK1 NUAK family, SNF1-like kinase, 1 2.05173
RHOH ras homolog family member H 2.04872
TFRC transferrin receptor 2.04623
CDK18 cyclin-dependent kinase 18 2.04569
DAAM2 dishevelled associated activator of morphogenesis 2 2.04122
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.04024
CBX8 chromobox homolog 8 2.03978
SOCS1 suppressor of cytokine signaling 1 2.03682
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 2.03383
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.03366
DND1 DND microRNA-mediated repression inhibitor 1 2.03298
PARK7 parkinson protein 7 2.02774
SCGB1D2 secretoglobin, family 1D, member 2 2.02753
A2M alpha-2-macroglobulin 2.02624
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.02383
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.02289
SCPEP1 serine carboxypeptidase 1 2.02222
CNGA1 cyclic nucleotide gated channel alpha 1 2.01518
SIDT1 SID1 transmembrane family, member 1 2.01279
KLHL1 kelch-like family member 1 2.01192
TRIM13 tripartite motif containing 13 2.01066
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.00831
CAPN1 calpain 1, (mu/I) large subunit 2.00702
CCL19 chemokine (C-C motif) ligand 19 2.00619
IL7R interleukin 7 receptor 2.00184
KRT5 keratin 5, type II 2.00145
APOL6 apolipoprotein L, 6 2.00117
EVI2A ecotropic viral integration site 2A 2.00013

decreased expression

Symbol Name Standardized Value
MSN moesin -4.87067
DNM1L dynamin 1-like -4.84792
HMG20B high mobility group 20B -4.4914
IFRD2 interferon-related developmental regulator 2 -4.06871
KDM3A lysine (K)-specific demethylase 3A -3.44947
CLTB clathrin, light chain B -3.3529
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -3.17204
CAPRIN2 caprin family member 2 -3.17023
MTERF3 mitochondrial transcription termination factor 3 -3.15943
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.03809
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.79606
TMEM147 transmembrane protein 147 -2.71515
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.67572
ERGIC2 ERGIC and golgi 2 -2.6734
CDK4 cyclin-dependent kinase 4 -2.6322
HSPA1A heat shock 70kDa protein 1A -2.62061
TUFM Tu translation elongation factor, mitochondrial -2.59333
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.53891
LGALSL lectin, galactoside-binding-like -2.52926
CXCL3 chemokine (C-X-C motif) ligand 3 -2.51362
DONSON downstream neighbor of SON -2.51085
DDA1 DET1 and DDB1 associated 1 -2.46589
CBR1 carbonyl reductase 1 -2.44204
BASP1 brain abundant, membrane attached signal protein 1 -2.43747
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -2.43124
TDRD7 tudor domain containing 7 -2.41626
AXIN1 axin 1 -2.40354
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.32743
GIPC1 GIPC PDZ domain containing family, member 1 -2.30748
SMAGP small cell adhesion glycoprotein -2.28406
TMEM115 transmembrane protein 115 -2.27179
BMAL2 basic helix-loop-helix ARNT like 2 -2.26972
NT5DC2 5'-nucleotidase domain containing 2 -2.23506
MED21 mediator complex subunit 21 -2.22125
RANGRF RAN guanine nucleotide release factor -2.21205
UTP11 UTP11 small subunit processome component -2.19594
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.19569
CEP112 centrosomal protein 112kDa -2.19198
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.17198
BMP6 bone morphogenetic protein 6 -2.16218
TUBG1 tubulin, gamma 1 -2.15004
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -2.14275
C1QBP complement component 1, q subcomponent binding protein -2.13315
ZNF302 zinc finger protein 302 -2.13081
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 -2.12691
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.11142
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.11037
MAP2K2 mitogen-activated protein kinase kinase 2 -2.10073
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -2.09442
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.08491
ENO2 enolase 2 (gamma, neuronal) -2.03562
NCOA6 nuclear receptor coactivator 6 -2.02707
INTS12 integrator complex subunit 12 -2.02498
OLA1 Obg-like ATPase 1 -2.02348
WASHC3 WASH complex subunit 3 -2.02003
MKRN2 makorin ring finger protein 2 -2.01241
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.00563
TTC4 tetratricopeptide repeat domain 4 -2.00272
CTPS1 CTP synthase 1 -2.00084