CRCGN017_MCF10A.TP53.M_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclophosphamide 33.78 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.79808
WFS1 Wolfram syndrome 1 (wolframin) 2.95183
EVL Enah/Vasp-like 2.6339
ACAA1 acetyl-CoA acyltransferase 1 2.5511
RBP4 retinol binding protein 4, plasma 2.23472
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.21221
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.2048
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.15596
MMP2 matrix metallopeptidase 2 2.09417
PIEZO1 piezo-type mechanosensitive ion channel component 1 2.09355
ZBTB35 zinc finger and BTB domain containing 35 2.07941
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.01502

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.81698
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.15553
KRT14 keratin 14, type I -3.77965
SMC1A structural maintenance of chromosomes 1A -3.48824
ENOPH1 enolase-phosphatase 1 -3.34384
COTL1 coactosin-like F-actin binding protein 1 -2.42762
PCCB propionyl CoA carboxylase, beta polypeptide -2.29667
LPO lactoperoxidase -2.18095
THAP11 THAP domain containing 11 -2.17232
UFM1 ubiquitin-fold modifier 1 -2.16546
SCYL3 SCY1-like 3 (S. cerevisiae) -2.14963
PUDP pseudouridine 5'-phosphatase -2.10351
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.09376
IGFBP7 insulin-like growth factor binding protein 7 -2.07776
PNPLA4 patatin-like phospholipase domain containing 4 -2.06474
HSPA1A heat shock 70kDa protein 1A -2.01896
SLIT2 slit homolog 2 (Drosophila) -2.00672
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.00607