CRCGN017_MCF10A.TP53.M_24H:P15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclophosphamide 11.26 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.93274
AGR2 anterior gradient 2 4.79193
SQOR sulfide quinone oxidoreductase 3.99389
MELK maternal embryonic leucine zipper kinase 3.99008
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.91482
SNX11 sorting nexin 11 3.65051
GPER1 G protein-coupled estrogen receptor 1 3.54636
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.43681
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.34196
MPC2 mitochondrial pyruvate carrier 2 2.20761
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.09486

decreased expression

Symbol Name Standardized Value
VDAC1 voltage-dependent anion channel 1 -4.90746
KRT14 keratin 14, type I -4.22691
KDM3A lysine (K)-specific demethylase 3A -3.89917
ITGA10 integrin, alpha 10 -2.80573
CBR3 carbonyl reductase 3 -2.43107
RAI14 retinoic acid induced 14 -2.40995
C1QBP complement component 1, q subcomponent binding protein -2.27395
REXO2 RNA exonuclease 2 -2.17052
BPHL biphenyl hydrolase-like (serine hydrolase) -2.11643
PRPF18 pre-mRNA processing factor 18 -2.10865
BMP5 bone morphogenetic protein 5 -2.0649
STX1A syntaxin 1A (brain) -2.05551
CCN2 cellular communication network factor 2 -2.01643
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -2.0129