CRCGN017_MCF10A.TP53.M_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ifosfamide 101.19 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

168 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 4.53464
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.42524
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.275
MAP7 microtubule-associated protein 7 4.15047
FCHO1 FCH domain only 1 4.02874
TRAM2 translocation associated membrane protein 2 3.37199
UGT8 UDP glycosyltransferase 8 3.15569
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.15452
LRRC15 leucine rich repeat containing 15 3.139
ARHGAP22 Rho GTPase activating protein 22 2.94104
CNPY3 canopy FGF signaling regulator 3 2.71015
PCSK1 proprotein convertase subtilisin/kexin type 1 2.70849
TBC1D31 TBC1 domain family, member 31 2.70427
SOX1 SRY (sex determining region Y)-box 1 2.64013
PAQR5 progestin and adipoQ receptor family member V 2.57766
FBXL12 F-box and leucine-rich repeat protein 12 2.52874
C5 complement component 5 2.45426
SYN1 synapsin I 2.45266
NTN1 netrin 1 2.43859
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.42851
DRD4 dopamine receptor D4 2.42544
PTTG2 pituitary tumor-transforming 2 2.41478
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.39835
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.39292
CABP1 calcium binding protein 1 2.37873
SCN2A sodium channel, voltage gated, type II alpha subunit 2.37858
CAPN9 calpain 9 2.37727
IAPP islet amyloid polypeptide 2.37583
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.37533
TEF thyrotrophic embryonic factor 2.37138
ARHGAP4 Rho GTPase activating protein 4 2.36778
DTWD1 DTW domain containing 1 2.35469
PPP1R2C PPP1R2C family member C 2.34949
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.33888
CUZD1 CUB and zona pellucida-like domains 1 2.30498
GLCE glucuronic acid epimerase 2.30306
ADRA1D adrenoceptor alpha 1D 2.28706
CLDN14 claudin 14 2.28487
GARRE1 granule associated Rac and RHOG effector 1 2.26977
MRPS18C mitochondrial ribosomal protein S18C 2.26461
ADRA1B adrenoceptor alpha 1B 2.26434
RIBC2 RIB43A domain with coiled-coils 2 2.26243
LRRC3 leucine rich repeat containing 3 2.26006
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.2569
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.25578
MRNIP MRN complex interacting protein 2.23731
DNASE1 deoxyribonuclease I 2.23032
CRYBA2 crystallin, beta A2 2.22853
SRD5A3 steroid 5 alpha-reductase 3 2.22846
DIPK1A divergent protein kinase domain 1A 2.22279
WNT1 wingless-type MMTV integration site family, member 1 2.22193
ICAM5 intercellular adhesion molecule 5, telencephalin 2.2169
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.21595
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.21476
KMT2D lysine (K)-specific methyltransferase 2D 2.2032
EFNA2 ephrin-A2 2.20209
EPHA5 EPH receptor A5 2.19535
ATOH1 atonal homolog 1 (Drosophila) 2.19524
ADGB androglobin 2.19215
SYT13 synaptotagmin XIII 2.18426
BCCIP BRCA2 and CDKN1A interacting protein 2.18147
FGF8 fibroblast growth factor 8 (androgen-induced) 2.18126
ANGPTL2 angiopoietin-like 2 2.18083
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.18
MEST mesoderm specific transcript 2.17928
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.17883
MEF2B myocyte enhancer factor 2B 2.17667
SOX30 SRY (sex determining region Y)-box 30 2.16396
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 2.15991
PKD2L2 polycystic kidney disease 2-like 2 2.1547
KLK15 kallikrein-related peptidase 15 2.1488
MMP13 matrix metallopeptidase 13 2.14511
ETV3 ets variant 3 2.13948
TSPAN2 tetraspanin 2 2.1383
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 2.13496
MRPL4 mitochondrial ribosomal protein L4 2.13458
MRPS10 mitochondrial ribosomal protein S10 2.13407
KREMEN2 kringle containing transmembrane protein 2 2.13259
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.1281
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.12647
BMP8B bone morphogenetic protein 8b 2.12468
RPAIN RPA interacting protein 2.12447
CCNK cyclin K 2.12234
SSBP3 single stranded DNA binding protein 3 2.11983
SOX21 SRY (sex determining region Y)-box 21 2.11257
SOX3 SRY (sex determining region Y)-box 3 2.11082
IPO13 importin 13 2.11059
FMO1 flavin containing monooxygenase 1 2.10417
NUAK1 NUAK family, SNF1-like kinase, 1 2.10227
S1PR5 sphingosine-1-phosphate receptor 5 2.10036
RFXAP regulatory factor X-associated protein 2.09987
GALR2 galanin receptor 2 2.0949
PRKCG protein kinase C, gamma 2.09129
GPR25 G protein-coupled receptor 25 2.0897
TPPP tubulin polymerization promoting protein 2.08752
GJA5 gap junction protein, alpha 5, 40kDa 2.08716
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.08431
NT5DC3 5'-nucleotidase domain containing 3 2.0827
ARC activity-regulated cytoskeleton-associated protein 2.08034
KCNK5 potassium channel, two pore domain subfamily K, member 5 2.07462
UTS2 urotensin 2 2.07212
MYBPH myosin binding protein H 2.07209
ZNF93 zinc finger protein 93 2.06829
AIRIM AFG2 interacting ribosome maturation factor 2.06466
MNS1 meiosis-specific nuclear structural 1 2.05963
FOXB1 forkhead box B1 2.05326
PNLIP pancreatic lipase 2.04901
TXNL4B thioredoxin-like 4B 2.04429
DEPDC5 DEP domain containing 5 2.03613
CALCR calcitonin receptor 2.03445
NKX2-2 NK2 homeobox 2 2.03243
FSD1 fibronectin type III and SPRY domain containing 1 2.02833
RAPSN receptor-associated protein of the synapse 2.0251
ANGPTL8 angiopoietin like 8 2.02297
VTN vitronectin 2.02131
OMP olfactory marker protein 2.02023
COBLL1 cordon-bleu WH2 repeat protein-like 1 2.0148
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.01276
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.0127
KIF24 kinesin family member 24 2.00795
SHH sonic hedgehog 2.00752
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.00595
FOXL1 forkhead box L1 2.00586
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.0038
HOXD12 homeobox D12 2.00301
ADRB1 adrenoceptor beta 1 2.00169

decreased expression

Symbol Name Standardized Value
LYPLA1 lysophospholipase I -4.70137
PCNA proliferating cell nuclear antigen -4.6855
CD58 CD58 molecule -4.40133
MSMO1 methylsterol monooxygenase 1 -4.28989
KRT14 keratin 14, type I -3.65472
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.39776
IGFBP7 insulin-like growth factor binding protein 7 -2.99719
PCCB propionyl CoA carboxylase, beta polypeptide -2.96963
THAP11 THAP domain containing 11 -2.90427
COCH cochlin -2.70175
GTF2H5 general transcription factor IIH, polypeptide 5 -2.65943
IL4R interleukin 4 receptor -2.65917
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.54929
METTL9 methyltransferase like 9 -2.5413
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -2.52605
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.51384
CD320 CD320 molecule -2.40787
VAT1 vesicle amine transport 1 -2.39208
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.29768
MSN moesin -2.29743
SEC61G Sec61 gamma subunit -2.27309
ATP13A2 ATPase type 13A2 -2.2468
NIPSNAP2 nipsnap homolog 2 -2.24355
CBR3 carbonyl reductase 3 -2.23245
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.22845
PRNP prion protein -2.2207
TASP1 taspase, threonine aspartase, 1 -2.20711
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.19022
CHSY1 chondroitin sulfate synthase 1 -2.18422
SLIRP SRA stem-loop interacting RNA binding protein -2.17447
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.16779
TMEM258 transmembrane protein 258 -2.15157
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.14666
NUP43 nucleoporin 43kDa -2.13008
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.0916
GRN granulin -2.08522
CD81 CD81 molecule -2.05767
TCP1 t-complex 1 -2.01135
NRIP3 nuclear receptor interacting protein 3 -2.00965
CCDC15 coiled-coil domain containing 15 -2.00814
DYNLRB1 dynein, light chain, roadblock-type 1 -2.00461
TESC tescalcin -2.00385