CRCGN017_MCF10A.TP53.M_24H:P17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ifosfamide 33.73 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.23031
CCL2 chemokine (C-C motif) ligand 2 3.83956
CERK ceramide kinase 3.42135
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.11874
TGFB3 transforming growth factor, beta 3 3.01131
FCHO1 FCH domain only 1 2.87465
TXNL4B thioredoxin-like 4B 2.807
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.73246
UGDH UDP-glucose 6-dehydrogenase 2.71443
GET1 guided entry of tail-anchored proteins factor 1 2.49795
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.49564
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.44742
FSD1 fibronectin type III and SPRY domain containing 1 2.36614
ANAPC2 anaphase promoting complex subunit 2 2.35329
TBC1D31 TBC1 domain family, member 31 2.32347
MMP2 matrix metallopeptidase 2 2.31467
HHLA2 HERV-H LTR-associating 2 2.30855
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.29604
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.27184
P3H2 prolyl 3-hydroxylase 2 2.26227
CDC37 cell division cycle 37 2.26032
NTF3 neurotrophin 3 2.26
CNPY3-GNMT CNPY3-GNMT readthrough 2.23374
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.21857
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.19889
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.18085
PYY peptide YY 2.15718
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.15606
BTK Bruton agammaglobulinemia tyrosine kinase 2.14306
PRPF31 pre-mRNA processing factor 31 2.13236
GCG glucagon 2.09946
ABHD17A abhydrolase domain containing 17A 2.08697
ZG16 zymogen granule protein 16 2.08635
HABP2 hyaluronan binding protein 2 2.07686
GUCA2B guanylate cyclase activator 2B (uroguanylin) 2.06847
TK1 thymidine kinase 1, soluble 2.06651
NOL11 nucleolar protein 11 2.04922
PEX14 peroxisomal biogenesis factor 14 2.03531
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 2.01937
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.01327
C5 complement component 5 2.00719
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.00614

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -6.67047
NGRN neugrin, neurite outgrowth associated -4.57198
PCNA proliferating cell nuclear antigen -4.03697
NUP93 nucleoporin 93kDa -3.85853
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.81011
STXBP2 syntaxin binding protein 2 -3.19963
TCERG1 transcription elongation regulator 1 -3.12191
HEATR1 HEAT repeat containing 1 -2.75539
MSMO1 methylsterol monooxygenase 1 -2.72756
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.63461
AXIN1 axin 1 -2.54562
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.51919
RNF4 ring finger protein 4 -2.382
DDRGK1 DDRGK domain containing 1 -2.32516
SH3D19 SH3 domain containing 19 -2.30223
COX5A cytochrome c oxidase subunit Va -2.25662
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.18009
MSN moesin -2.15545
LAMC2 laminin, gamma 2 -2.15437
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.14271
TES testin LIM domain protein -2.11338
VAT1 vesicle amine transport 1 -2.11245
TM9SF2 transmembrane 9 superfamily member 2 -2.10417
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.09594
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.06841
PANK2 pantothenate kinase 2 -2.06213
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.00447