CRCGN017_MCF10A.TP53.M_24H:P18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ifosfamide 11.24 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

50 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.88546
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.7584
INTS3 integrator complex subunit 3 2.8365
RASIP1 Ras interacting protein 1 2.26622
MFAP4 microfibrillar-associated protein 4 2.2305
FAT4 FAT atypical cadherin 4 2.19199
SOCS2 suppressor of cytokine signaling 2 2.17928
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.13577
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.12998
INTS13 integrator complex subunit 13 2.05446
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.00495
CENPE centromere protein E, 312kDa 2.00111

decreased expression

Symbol Name Standardized Value
CHIC2 cysteine-rich hydrophobic domain 2 -5.36833
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.00441
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.83276
RNF167 ring finger protein 167 -3.7654
PCNA proliferating cell nuclear antigen -3.56977
NVL nuclear VCP-like -3.40214
TBCB tubulin folding cofactor B -3.11927
C1QBP complement component 1, q subcomponent binding protein -3.07406
MEA1 male-enhanced antigen 1 -2.82631
NT5DC2 5'-nucleotidase domain containing 2 -2.81233
TMEM147 transmembrane protein 147 -2.66868
TMEM230 transmembrane protein 230 -2.48937
IGFBP7 insulin-like growth factor binding protein 7 -2.46123
FBXO28 F-box protein 28 -2.4372
ACTN4 actinin, alpha 4 -2.42042
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.41963
WDR26 WD repeat domain 26 -2.41926
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 -2.31134
ERCC5 excision repair cross-complementation group 5 -2.30227
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.2921
COG7 component of oligomeric golgi complex 7 -2.29179
AGBL2 ATP/GTP binding protein-like 2 -2.2758
SUN2 Sad1 and UNC84 domain containing 2 -2.27132
FKBP1C FK506 binding protein 1C -2.25773
CFAP298 cilia and flagella associated protein 298 -2.21386
NGRN neugrin, neurite outgrowth associated -2.17652
LIN37 lin-37 DREAM MuvB core complex component -2.17597
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.15842
SERGEF secretion regulating guanine nucleotide exchange factor -2.15411
AKTIP AKT interacting protein -2.14619
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.14067
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -2.1166
TSGA10 testis specific, 10 -2.09975
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.08879
OSTM1 osteopetrosis associated transmembrane protein 1 -2.04775
UBA2 ubiquitin-like modifier activating enzyme 2 -2.03621
PANK2 pantothenate kinase 2 -2.01188
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.00704