CRCGN017_MCF10A.TP53.M_24H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(2-bromo-2-ethylbutanoyl)urea 33.07 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.15752
KLHL21 kelch-like family member 21 4.37184
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.21364
AGR2 anterior gradient 2 3.19888
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.06523
KDM5A lysine (K)-specific demethylase 5A 3.04085
ACAA1 acetyl-CoA acyltransferase 1 2.92771
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.48603
CGRRF1 cell growth regulator with ring finger domain 1 2.46365
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.13777
LYN LYN proto-oncogene, Src family tyrosine kinase 2.10803
LEMD3 LEM domain containing 3 2.06578
KAT6B K(lysine) acetyltransferase 6B 2.06003
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.03324
ARID5B AT rich interactive domain 5B (MRF1-like) 2.02301
MMP1 matrix metallopeptidase 1 2.00015

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -3.77095
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.61728
TBCB tubulin folding cofactor B -2.65466
HEATR1 HEAT repeat containing 1 -2.61003
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.5969
MSN moesin -2.5653
DCTD dCMP deaminase -2.18325
STK25 serine/threonine kinase 25 -2.09272
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.00889