| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | benzo[k]fluoranthene 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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110 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:P23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C2CD2 | C2 calcium-dependent domain containing 2 | 5.2374 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.3957 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 3.72685 |
| HBB | hemoglobin, beta | 3.64652 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 3.4877 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.28122 |
| MSRA | methionine sulfoxide reductase A | 3.23185 |
| ATP11B | ATPase, class VI, type 11B | 3.14855 |
| CDK7 | cyclin-dependent kinase 7 | 3.08815 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.94115 |
| CAPN1 | calpain 1, (mu/I) large subunit | 2.74275 |
| SLC75A1 | solute carrier family 75 member 1 | 2.68565 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.6126 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 2.40595 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 2.39165 |
| JAM3 | junctional adhesion molecule 3 | 2.3764 |
| COX5B | cytochrome c oxidase subunit Vb | 2.37517 |
| PPIF | peptidylprolyl isomerase F | 2.37448 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.344 |
| SNRNP27 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5) | 2.34063 |
| ZNF586 | zinc finger protein 586 | 2.3365 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.308 |
| NXT2 | nuclear transport factor 2-like export factor 2 | 2.3065 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 2.3055 |
| HEBP2 | heme binding protein 2 | 2.29155 |
| SASH1 | SAM and SH3 domain containing 1 | 2.24775 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 2.2358 |
| PYGL | phosphorylase, glycogen, liver | 2.22915 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 2.2182 |
| ZNF134 | zinc finger protein 134 | 2.21075 |
| STAT4 | signal transducer and activator of transcription 4 | 2.2047 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 2.19735 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.17945 |
| RHOA | ras homolog family member A | 2.1656 |
| MPC2 | mitochondrial pyruvate carrier 2 | 2.15465 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.15365 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 2.1427 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.113 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 2.103 |
| EXTL2 | exostosin-like glycosyltransferase 2 | 2.0954 |
| FAM124B | family with sequence similarity 124B | 2.09485 |
| USP6 | ubiquitin specific peptidase 6 | 2.09005 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | 2.0851 |
| TMEM126B | transmembrane protein 126B | 2.06755 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 2.06485 |
| TRAPPC2L | trafficking protein particle complex 2-like | 2.0568 |
| ZNF587 | zinc finger protein 587 | 2.03145 |
| MED24 | mediator complex subunit 24 | 2.018 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 2.01745 |
| NSF | N-ethylmaleimide-sensitive factor | 2.0017 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | 2.0014 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HAT1 | histone acetyltransferase 1 | -5.6506 |
| SMNDC1 | survival motor neuron domain containing 1 | -5.54775 |
| KRT14 | keratin 14, type I | -4.68065 |
| RXYLT1 | ribitol xylosyltransferase 1 | -4.32938 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.2906 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -4.20773 |
| SLC35F2 | solute carrier family 35, member F2 | -4.18135 |
| REEP5 | receptor accessory protein 5 | -4.14832 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -3.70125 |
| CLTB | clathrin, light chain B | -3.68165 |
| TRAPPC3 | trafficking protein particle complex 3 | -3.67335 |
| AGO1 | argonaute RISC catalytic component 1 | -3.20515 |
| OAT | ornithine aminotransferase | -3.03115 |
| SF3A3 | splicing factor 3a, subunit 3, 60kDa | -2.89715 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.84845 |
| MAP7D1 | MAP7 domain containing 1 | -2.7792 |
| IPP | intracisternal A particle-promoted polypeptide | -2.62995 |
| SLC22A8 | solute carrier family 22 (organic anion transporter), member 8 | -2.5313 |
| PRODH2 | proline dehydrogenase (oxidase) 2 | -2.47985 |
| CDCA8 | cell division cycle associated 8 | -2.41995 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.40535 |
| MEAF6 | MYST/Esa1-associated factor 6 | -2.39745 |
| MSMO1 | methylsterol monooxygenase 1 | -2.39645 |
| MSN | moesin | -2.3894 |
| AMPD2 | adenosine monophosphate deaminase 2 | -2.36375 |
| ITGAV | integrin, alpha V | -2.3463 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -2.34235 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -2.27775 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -2.27085 |
| EVI5 | ecotropic viral integration site 5 | -2.27067 |
| IL4R | interleukin 4 receptor | -2.26745 |
| BCAS3 | breast carcinoma amplified sequence 3 | -2.24975 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | -2.24815 |
| FBXO21 | F-box protein 21 | -2.24183 |
| KIF1A | kinesin family member 1A | -2.24175 |
| RNF44 | ring finger protein 44 | -2.2404 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | -2.21065 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | -2.20685 |
| AGBL5 | ATP/GTP binding protein-like 5 | -2.1994 |
| TULP3 | tubby like protein 3 | -2.19397 |
| DKC1 | dyskeratosis congenita 1, dyskerin | -2.14977 |
| SAP30L | SAP30-like | -2.1362 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -2.11865 |
| ZNF652 | zinc finger protein 652 | -2.109 |
| FAIM | Fas apoptotic inhibitory molecule | -2.0941 |
| SOX9 | SRY (sex determining region Y)-box 9 | -2.07615 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -2.07615 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | -2.0662 |
| CETN2 | centrin, EF-hand protein, 2 | -2.0591 |
| MTFR1 | mitochondrial fission regulator 1 | -2.05295 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -2.04982 |
| ZNF148 | zinc finger protein 148 | -2.04915 |
| OXLD1 | oxidoreductase-like domain containing 1 | -2.04665 |
| KRT23 | keratin 23, type I | -2.04195 |
| F8A2 | coagulation factor VIII-associated 2 | -2.03515 |
| UBQLN2 | ubiquilin 2 | -2.03405 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | -2.02045 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | -2.01255 |
| ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | -2.0017 |
