CRCGN017_MCF10A.WT.HP_24H:A03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.01835
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.88713
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.87853
SNAP25 synaptosomal-associated protein, 25kDa 4.84772
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 4.53642
STAT5B signal transducer and activator of transcription 5B 4.39984
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.2023
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.87752
MAP7 microtubule-associated protein 7 3.67887
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.50242
PLSCR1 phospholipid scramblase 1 3.18175
CNRIP1 cannabinoid receptor interacting protein 1 3.1474
ACAA1 acetyl-CoA acyltransferase 1 3.12573
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.76065
RUNDC3B RUN domain containing 3B 2.7574
TBX2 T-box 2 2.74998
RBKS ribokinase 2.71539
CSNK1G3 casein kinase 1, gamma 3 2.63194
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.53942
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.5173
CNPY3 canopy FGF signaling regulator 3 2.51137
ASXL1 additional sex combs like transcriptional regulator 1 2.36182
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.20583
HP1BP3 heterochromatin protein 1, binding protein 3 2.18454
ZBTB35 zinc finger and BTB domain containing 35 2.15109
TMOD3 tropomodulin 3 (ubiquitous) 2.10923
GRAMD1B GRAM domain containing 1B 2.10594
PLAC8 placenta-specific 8 2.09577
MAPK6 mitogen-activated protein kinase 6 2.08326
SIRAL2 SIR2 antiphage like 2 2.07677
IKZF5 IKAROS family zinc finger 5 (Pegasus) 2.06496

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -4.7419
ENOPH1 enolase-phosphatase 1 -4.60394
PFN1 profilin 1 -4.26354
UFM1 ubiquitin-fold modifier 1 -4.21248
TXNDC9 thioredoxin domain containing 9 -4.14687
GDF15 growth differentiation factor 15 -3.50196
NVL nuclear VCP-like -3.49544
TENT4A terminal nucleotidyltransferase 4A -3.21349
NT5DC2 5'-nucleotidase domain containing 2 -3.20286
KRT14 keratin 14, type I -2.98541
WASHC4 WASH complex subunit 4 -2.8718
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.7672
MSMO1 methylsterol monooxygenase 1 -2.68151
IPO13 importin 13 -2.62503
RAI14 retinoic acid induced 14 -2.61381
FOLR3 folate receptor 3 (gamma) -2.54579
PRR36 proline rich 36 -2.5349
ARG2 arginase 2 -2.52956
BARX1 BARX homeobox 1 -2.51026
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.5087
ZNG1A Zn regulated GTPase metalloprotein activator 1A -2.48892
SCFD1 sec1 family domain containing 1 -2.4637
MEGF6 multiple EGF-like-domains 6 -2.4458
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.41656
LOC102724652 alpha-crystallin A chain -2.4082
C8G complement component 8, gamma polypeptide -2.38619
GH1 growth hormone 1 -2.38209
KIFBP kinesin family binding protein -2.35364
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.32598
ALAS1 5'-aminolevulinate synthase 1 -2.31799
APMAP adipocyte plasma membrane associated protein -2.29763
GPR31 G protein-coupled receptor 31 -2.24944
ZNF274 zinc finger protein 274 -2.23134
ARID5A AT rich interactive domain 5A (MRF1-like) -2.1844
RLN2 relaxin 2 -2.18311
INHA inhibin, alpha -2.17645
CCNJL cyclin J-like -2.16563
TRAPPC6A trafficking protein particle complex 6A -2.15888
ALOX15B arachidonate 15-lipoxygenase, type B -2.15736
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.14961
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -2.14718
ZNF268 zinc finger protein 268 -2.08838
GH2 growth hormone 2 -2.08691
RASAL1 RAS protein activator like 1 (GAP1 like) -2.08603
KPLCE KPRP N-terminal and LCE C-terminal like protein -2.07968
SIX6 SIX homeobox 6 -2.07511
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 -2.0697
LOC102724560 cystathionine beta-synthase -2.06883
CSHL1 chorionic somatomammotropin hormone-like 1 -2.06554
POMC proopiomelanocortin -2.06319
ORAI3 ORAI calcium release-activated calcium modulator 3 -2.02467
BPHL biphenyl hydrolase-like (serine hydrolase) -2.01929
HBG1 hemoglobin, gamma A -2.00967
FSHB follicle stimulating hormone, beta polypeptide -2.00908
ZNF91 zinc finger protein 91 -2.00423