CRCGN017_MCF10A.WT.HP_24H:A04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 9.49082
CCL2 chemokine (C-C motif) ligand 2 5.21629
MAMLD1 mastermind-like domain containing 1 4.63453
ABHD6 abhydrolase domain containing 6 4.55884
E2F2 E2F transcription factor 2 4.55746
STMN2 stathmin 2 3.5764
TBX2 T-box 2 3.55031
AMDHD2 amidohydrolase domain containing 2 3.51392
CERK ceramide kinase 3.46422
OLFM1 olfactomedin 1 3.43832
SCG3 secretogranin III 3.11697
SNAP91 synaptosomal-associated protein, 91kDa 3.08175
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 3.05992
RPH3A rabphilin 3A 2.93797
NSG2 neuronal vesicle trafficking associated 2 2.85886
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.84716
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.83932
VSNL1 visinin-like 1 2.83485
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.81519
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 2.7673
SV2B synaptic vesicle glycoprotein 2B 2.76126
SYN1 synapsin I 2.64232
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.63813
KDM5D lysine (K)-specific demethylase 5D 2.63075
NEFL neurofilament, light polypeptide 2.62386
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.56243
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.55903
NEFM neurofilament, medium polypeptide 2.5493
CDH10 cadherin 10, type 2 (T2-cadherin) 2.5462
CALCB calcitonin-related polypeptide beta 2.47451
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.4139
NSG1 neuron specific gene family member 1 2.36908
PCSK2 proprotein convertase subtilisin/kexin type 2 2.36612
ADGRB3 adhesion G protein-coupled receptor B3 2.36331
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.36138
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.36118
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.34275
ACTL6B actin-like 6B 2.31662
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.31356
PNOC prepronociceptin 2.2957
RUNDC3B RUN domain containing 3B 2.29437
TMEM43 transmembrane protein 43 2.2931
MKKS McKusick-Kaufman syndrome 2.28061
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.24528
ASTN1 astrotactin 1 2.24292
GLRB glycine receptor, beta 2.23452
FRRS1L ferric-chelate reductase 1-like 2.22522
SDAD1 SDA1 domain containing 1 2.19531
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.16466
TAGLN3 transgelin 3 2.12956
NMI N-myc (and STAT) interactor 2.1254
LGI1 leucine-rich, glioma inactivated 1 2.11785
IMMT inner membrane protein, mitochondrial 2.1088
JAKMIP2 janus kinase and microtubule interacting protein 2 2.09499
NEUROD6 neuronal differentiation 6 2.08658
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.07883
USP9Y ubiquitin specific peptidase 9, Y-linked 2.05631
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.02598
CBLN1 cerebellin 1 precursor 2.01382
CARTPT CART prepropeptide 2.01189
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.00172
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.0015

decreased expression

Symbol Name Standardized Value
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -8.90012
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -5.80179
COG7 component of oligomeric golgi complex 7 -5.28233
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.20977
GDF15 growth differentiation factor 15 -4.0002
CDC20 cell division cycle 20 -3.73831
S100A8 S100 calcium binding protein A8 -3.43631
MSMO1 methylsterol monooxygenase 1 -2.9843
LINC02762 long intergenic non-protein coding RNA 2762 -2.89462
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.83783
RAI14 retinoic acid induced 14 -2.80402
COTL1 coactosin-like F-actin binding protein 1 -2.79792
MSN moesin -2.79504
IGFBP7 insulin-like growth factor binding protein 7 -2.50776
NGRN neugrin, neurite outgrowth associated -2.50199
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.48017
SMC1A structural maintenance of chromosomes 1A -2.35587
PSIP1 PC4 and SFRS1 interacting protein 1 -2.30755
TENT4A terminal nucleotidyltransferase 4A -2.30368
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.26813
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.24386
ZNF652 zinc finger protein 652 -2.22257
PLAGL1 pleiomorphic adenoma gene-like 1 -2.12538
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.12394
C1QBP complement component 1, q subcomponent binding protein -2.10578
SLC44A4 solute carrier family 44, member 4 -2.09532
CAPZB capping protein (actin filament) muscle Z-line, beta -2.07057
MAGT1 magnesium transporter 1 -2.02757
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.02516
SPAG1 sperm associated antigen 1 -2.0135