CRCGN017_MCF10A.WT.HP_24H:A05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

104 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 5.99265
MAMLD1 mastermind-like domain containing 1 4.9548
ANO1 anoctamin 1, calcium activated chloride channel 4.638
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.5186
WFS1 Wolfram syndrome 1 (wolframin) 4.13269
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.27716
BACE2 beta-site APP-cleaving enzyme 2 3.25109
OLFML2B olfactomedin-like 2B 2.99412
MCUR1 mitochondrial calcium uniporter regulator 1 2.92327
PXMP2 peroxisomal membrane protein 2, 22kDa 2.62251
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.45844
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.45025
HMGB3 high mobility group box 3 2.41578
KRT76 keratin 76, type II 2.40342
BLM Bloom syndrome, RecQ helicase-like 2.39361
DROSHA drosha, ribonuclease type III 2.36184
TYK2 tyrosine kinase 2 2.36131
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 2.35653
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.34284
IPCEF1 interaction protein for cytohesin exchange factors 1 2.31781
TBX2 T-box 2 2.25973
MRPL48 mitochondrial ribosomal protein L48 2.23509
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.2282
KLK12 kallikrein-related peptidase 12 2.2066
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.20027
UQCRC2 ubiquinol-cytochrome c reductase core protein II 2.14424
GPR183 G protein-coupled receptor 183 2.13729
MTMR2 myotubularin related protein 2 2.13175
KIN Kin17 DNA and RNA binding protein 2.12853
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.12257
ATP5F1C ATP synthase F1 subunit gamma 2.12193
DCP2 decapping mRNA 2 2.11905
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.11223
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.11142
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.10698
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.09894
MBIP MAP3K12 binding inhibitory protein 1 2.09887
UQCRH ubiquinol-cytochrome c reductase hinge protein 2.09636
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.06382
BTBD1 BTB (POZ) domain containing 1 2.05202
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.0463
CCL2 chemokine (C-C motif) ligand 2 2.03578

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -7.08738
GDF15 growth differentiation factor 15 -5.87978
NPDC1 neural proliferation, differentiation and control, 1 -5.47802
TCTA T-cell leukemia translocation altered -5.45406
TSPAN4 tetraspanin 4 -4.99482
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.90901
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.72479
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -4.71872
CHIC2 cysteine-rich hydrophobic domain 2 -4.56558
CD320 CD320 molecule -4.28068
UFM1 ubiquitin-fold modifier 1 -4.25702
S100A8 S100 calcium binding protein A8 -4.05767
PSENEN presenilin enhancer gamma secretase subunit -3.68007
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.56131
MSMO1 methylsterol monooxygenase 1 -3.36486
SORBS3 sorbin and SH3 domain containing 3 -3.35512
CD81 CD81 molecule -3.21281
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.8095
IFRD2 interferon-related developmental regulator 2 -2.78148
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.74234
QTRT1 queuine tRNA-ribosyltransferase 1 -2.68109
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.64303
SCYL3 SCY1-like 3 (S. cerevisiae) -2.61509
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.61018
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.55529
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.5314
PREB prolactin regulatory element binding -2.52255
LHFPL6 LHFPL tetraspan subfamily member 6 -2.42493
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) -2.39376
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.38575
NAP1L4 nucleosome assembly protein 1-like 4 -2.37765
ZNF76 zinc finger protein 76 -2.37579
CYB561D2 cytochrome b561 family, member D2 -2.34456
JMJD4 jumonji domain containing 4 -2.32826
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.31016
CDC37 cell division cycle 37 -2.30191
SQSTM1 sequestosome 1 -2.27137
RGPD1 RANBP2-like and GRIP domain containing 1 -2.23163
THTPA thiamine triphosphatase -2.22854
TCF20 transcription factor 20 (AR1) -2.22344
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -2.21402
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -2.19085
ARSA arylsulfatase A -2.17838
ACOD1 aconitate decarboxylase 1 -2.14654
BPHL biphenyl hydrolase-like (serine hydrolase) -2.11252
SPRED2 sprouty-related, EVH1 domain containing 2 -2.09073
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.07821
TMEM80 transmembrane protein 80 -2.07687
CREB3L4 cAMP responsive element binding protein 3-like 4 -2.07604
KDM5C lysine (K)-specific demethylase 5C -2.07225
PFN1 profilin 1 -2.06129
HPX hemopexin -2.05315
TBCC tubulin folding cofactor C -2.04847
YIPF6 Yip1 domain family, member 6 -2.04761
KLHDC3 kelch domain containing 3 -2.03758
PPP1R15A protein phosphatase 1, regulatory subunit 15A -2.03244
C1R complement component 1, r subcomponent -2.03008
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.02838
SPARCL1 SPARC-like 1 (hevin) -2.02575
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 -2.02548
KLF2 Kruppel-like factor 2 -2.00947
KXD1 KxDL motif containing 1 -2.00625