CRCGN017_MCF10A.WT.HP_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 7.75887
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.68161
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.27206
TIAM1 T-cell lymphoma invasion and metastasis 1 3.08621
ACAA1 acetyl-CoA acyltransferase 1 2.7602
SNAP25 synaptosomal-associated protein, 25kDa 2.64456
FBXO7 F-box protein 7 2.62827
RTN2 reticulon 2 2.6033
RAB21 RAB21, member RAS oncogene family 2.40978
MYLK myosin light chain kinase 2.27091
MTA2 metastasis associated 1 family, member 2 2.26246
MAP7 microtubule-associated protein 7 2.2358
KLHL21 kelch-like family member 21 2.16372
ABHD4 abhydrolase domain containing 4 2.00751
CCDC92 coiled-coil domain containing 92 2.00551

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -4.27635
TM9SF3 transmembrane 9 superfamily member 3 -3.35497
KIF14 kinesin family member 14 -2.77729
MSMO1 methylsterol monooxygenase 1 -2.68334
PUF60 poly-U binding splicing factor 60KDa -2.63137
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.40946
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.37411
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.33157
PRPF4 pre-mRNA processing factor 4 -2.22398
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.16247
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.12245
PFN1 profilin 1 -2.11277
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.05839
TM9SF2 transmembrane 9 superfamily member 2 -2.03915
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 -2.03359
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.0316