CRCGN017_MCF10A.WT.HP_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 100.71 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

117 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.62824
E2F2 E2F transcription factor 2 5.1779
MAP7 microtubule-associated protein 7 4.92465
MEF2C myocyte enhancer factor 2C 4.90915
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.38045
KIF5C kinesin family member 5C 4.26192
MTA2 metastasis associated 1 family, member 2 3.76235
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.45285
THRAP3 thyroid hormone receptor associated protein 3 3.342
ANKRD40 ankyrin repeat domain 40 3.30035
AGR2 anterior gradient 2 3.26475
WDR76 WD repeat domain 76 3.12495
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.91805
NUTF2 nuclear transport factor 2 2.85685
CERK ceramide kinase 2.7789
HIPK3 homeodomain interacting protein kinase 3 2.75813
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.71155
MDM4 MDM4, p53 regulator 2.60985
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.60845
PRPF39 pre-mRNA processing factor 39 2.55995
BAALC brain and acute leukemia, cytoplasmic 2.5576
TNRC6B trinucleotide repeat containing 6B 2.5327
STAT2 signal transducer and activator of transcription 2, 113kDa 2.50935
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.50053
PUS7 pseudouridylate synthase 7 (putative) 2.473
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.44962
SLF2 SMC5-SMC6 complex localization factor 2 2.44365
CLDND1 claudin domain containing 1 2.44
INCENP inner centromere protein antigens 135/155kDa 2.4182
CNRIP1 cannabinoid receptor interacting protein 1 2.39295
NFYA nuclear transcription factor Y, alpha 2.3778
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 2.37605
IL13RA2 interleukin 13 receptor, alpha 2 2.33905
PXDNL peroxidasin-like 2.3389
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.33035
RBBP5 retinoblastoma binding protein 5 2.32125
SYTL3 synaptotagmin-like 3 2.3203
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.3164
TPPP tubulin polymerization promoting protein 2.31385
WEE1 WEE1 G2 checkpoint kinase 2.2887
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.2794
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.25945
ABHD17B abhydrolase domain containing 17B 2.24875
TPM3 tropomyosin 3 2.2133
STRN3 striatin, calmodulin binding protein 3 2.1997
ODF2 outer dense fiber of sperm tails 2 2.19145
SIRAL2 SIR2 antiphage like 2 2.1681
SCARA3 scavenger receptor class A, member 3 2.14445
IL17B interleukin 17B 2.14205
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.1351
DSE dermatan sulfate epimerase 2.13095
RAB8A RAB8A, member RAS oncogene family 2.13015
PRM2 protamine 2 2.1221
SRSF6 serine/arginine-rich splicing factor 6 2.08628
CASQ2 calsequestrin 2 (cardiac muscle) 2.08365
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.07285
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.05985
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.0585
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.05335
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.0485
TPD52L2 tumor protein D52-like 2 2.046
CD34 CD34 molecule 2.03535
ARGLU1 arginine and glutamate rich 1 2.02325
TBCCD1 TBCC domain containing 1 2.0213
TMEM101 transmembrane protein 101 2.0113
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.00685
CHTOP chromatin target of PRMT1 2.00538
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.00357

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.93775
S100A8 S100 calcium binding protein A8 -5.0
TXNDC9 thioredoxin domain containing 9 -4.85415
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.68635
YME1L1 YME1-like 1 ATPase -4.64862
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.60875
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.24083
CLTB clathrin, light chain B -4.17395
HMG20B high mobility group 20B -3.83588
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.11633
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.86913
KRT14 keratin 14, type I -2.79105
MT2A metallothionein 2A -2.78725
NGRN neugrin, neurite outgrowth associated -2.72405
NANS N-acetylneuraminic acid synthase -2.47885
ANXA11 annexin A11 -2.4676
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.45747
PRCP prolylcarboxypeptidase (angiotensinase C) -2.40945
ABI1 abl-interactor 1 -2.38762
ZNF197 zinc finger protein 197 -2.37845
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.32815
ZNF268 zinc finger protein 268 -2.32555
TCF7 transcription factor 7 (T-cell specific, HMG-box) -2.26915
CD3D CD3d molecule, delta (CD3-TCR complex) -2.26855
FAM3A family with sequence similarity 3, member A -2.21992
TRIM24 tripartite motif containing 24 -2.21562
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.17385
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -2.171
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.15345
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -2.13325
AOC1 amine oxidase, copper containing 1 -2.1301
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.118
ERI2 ERI1 exoribonuclease family member 2 -2.105
ZNF354A zinc finger protein 354A -2.1039
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.0796
CALML4 calmodulin-like 4 -2.07255
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.0507
PRR15L proline rich 15-like -2.0496
LYZ lysozyme -2.0489
CD81 CD81 molecule -2.042
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.0408
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.0374
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -2.03715
MZT2A mitotic spindle organizing protein 2A -2.01705
KIN Kin17 DNA and RNA binding protein -2.01535
GGCT gamma-glutamylcyclotransferase -2.0141
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein -2.01345
KLHL36 kelch-like family member 36 -2.00725
TZMP1 transition zone microprotein 1 -2.00627