CRCGN017_MCF10A.WT.HP_24H:A08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 33.57 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.7618
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.47335
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.10635
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.95795
ZW10 zw10 kinetochore protein 4.7528
ZNF318 zinc finger protein 318 4.47538
TBX2 T-box 2 3.46742
MAGEB2 melanoma antigen family B2 2.75195
NRBF2 nuclear receptor binding factor 2 2.24235
CCL2 chemokine (C-C motif) ligand 2 2.1869
ZBTB35 zinc finger and BTB domain containing 35 2.16663
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.1347
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.12225
NCK2 NCK adaptor protein 2 2.0829
ARHGAP19 Rho GTPase activating protein 19 2.0767
CCDC86 coiled-coil domain containing 86 2.0635
TPM3 tropomyosin 3 2.0567
CCP110 centriolar coiled coil protein 110kDa 2.0504
NSD1 nuclear receptor binding SET domain protein 1 2.033
SMYD3 SET and MYND domain containing 3 2.03215
SFTPB surfactant protein B 2.0256

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.53085
MT2A metallothionein 2A -5.192
REEP5 receptor accessory protein 5 -5.09345
TXNDC9 thioredoxin domain containing 9 -4.97233
CDPF1 cysteine-rich, DPF motif domain containing 1 -4.4869
MT1X metallothionein 1X -4.16545
LAP3 leucine aminopeptidase 3 -3.835
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.83083
PFN1 profilin 1 -3.7205
IFRD2 interferon-related developmental regulator 2 -3.13375
TRPS1 trichorhinophalangeal syndrome I -2.76915
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.72968
MERTK MER proto-oncogene, tyrosine kinase -2.53017
VAMP5 vesicle-associated membrane protein 5 -2.2713
SCAND1 SCAN domain containing 1 -2.23655
CD320 CD320 molecule -2.2337
WASHC4 WASH complex subunit 4 -2.23232
CDK10 cyclin-dependent kinase 10 -2.23047
SH2D4A SH2 domain containing 4A -2.2206
MT1G metallothionein 1G -2.1669
ZDHHC14 zinc finger, DHHC-type containing 14 -2.1561
EMX2 empty spiracles homeobox 2 -2.1238
AUP1 ancient ubiquitous protein 1 -2.09225
ABHD14A abhydrolase domain containing 14A -2.087
KRT14 keratin 14, type I -2.0798
SECTM1 secreted and transmembrane 1 -2.07605
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.07405
PRCP prolylcarboxypeptidase (angiotensinase C) -2.06835
SCRG1 stimulator of chondrogenesis 1 -2.05615
YPEL5 yippee-like 5 (Drosophila) -2.0404
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.01765
IRAK4 interleukin-1 receptor-associated kinase 4 -2.01595
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.0121
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.00765
CD2AP CD2-associated protein -2.0049
APOM apolipoprotein M -2.00187
UNC50 unc-50 homolog (C. elegans) -2.00185
PSENEN presenilin enhancer gamma secretase subunit -2.0014