CRCGN017_MCF10A.WT.HP_24H:A09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 11.19 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 7.9288
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.92
STK10 serine/threonine kinase 10 4.8611
WFS1 Wolfram syndrome 1 (wolframin) 4.85845
KLHL21 kelch-like family member 21 4.67725
ZW10 zw10 kinetochore protein 3.93325
HBB hemoglobin, beta 3.50728
KDM5A lysine (K)-specific demethylase 5A 3.3289
KIF5C kinesin family member 5C 3.19675
TXNL4B thioredoxin-like 4B 3.0804
MARCO macrophage receptor with collagenous structure 3.00345
SMAD3 SMAD family member 3 2.81437
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.55413
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.54495
DNMBP dynamin binding protein 2.48585
TMEM101 transmembrane protein 101 2.4495
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.34855
MSRA methionine sulfoxide reductase A 2.3469
VBP1 von Hippel-Lindau binding protein 1 2.3234
SLC66A3 solute carrier family 66 member 3 2.3018
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.29765
GSTM5 glutathione S-transferase mu 5 2.21925
CNTFR ciliary neurotrophic factor receptor 2.16165
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.11805
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 2.11537
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.1151
WNT16 wingless-type MMTV integration site family, member 16 2.1081
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.10465
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.07195
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.0621
OCRL oculocerebrorenal syndrome of Lowe 2.0524
MATN2 matrilin 2 2.04275
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.04135
ADIPOR2 adiponectin receptor 2 2.041
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.03875
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.0119
EDC4 enhancer of mRNA decapping 4 2.0101
DGKH diacylglycerol kinase, eta 2.00845
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.0059
GDI2 GDP dissociation inhibitor 2 2.00233

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.7223
DYNLT3 dynein, light chain, Tctex-type 3 -5.7394
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.7255
RNF167 ring finger protein 167 -5.05155
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.97315
COG2 component of oligomeric golgi complex 2 -4.9325
CANT1 calcium activated nucleotidase 1 -4.7452
HMG20B high mobility group 20B -4.72307
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.63212
TXNDC9 thioredoxin domain containing 9 -4.46755
GDF15 growth differentiation factor 15 -4.15375
JMJD6 jumonji domain containing 6 -3.56082
CD58 CD58 molecule -3.34918
IFRD2 interferon-related developmental regulator 2 -3.20617
RCE1 Ras converting CAAX endopeptidase 1 -3.14905
C2CD5 C2 calcium-dependent domain containing 5 -3.12855
WASHC4 WASH complex subunit 4 -2.97788
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.95165
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.94644
TM9SF2 transmembrane 9 superfamily member 2 -2.89975
ACOX2 acyl-CoA oxidase 2, branched chain -2.8668
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.81525
BOLA2B bolA family member 2B -2.7756
RASAL2 RAS protein activator like 2 -2.65175
TKT transketolase -2.62725
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.60795
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.60315
RUSF1 RUS family member 1 -2.58453
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.574
SGK1 serum/glucocorticoid regulated kinase 1 -2.56205
AMACR alpha-methylacyl-CoA racemase -2.53783
MYO1D myosin ID -2.53125
BBC3 BCL2 binding component 3 -2.5138
UNC50 unc-50 homolog (C. elegans) -2.493
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.48885
COQ9 coenzyme Q9 -2.4841
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.4819
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -2.4372
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -2.36567
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.3465
MYO18A myosin XVIIIA -2.28835
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -2.2529
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.2363
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.21525
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.21325
CGREF1 cell growth regulator with EF-hand domain 1 -2.2048
AUP1 ancient ubiquitous protein 1 -2.1478
TCF15 transcription factor 15 (basic helix-loop-helix) -2.13865
S100A12 S100 calcium binding protein A12 -2.12925
DZIP1 DAZ interacting zinc finger protein 1 -2.12385
CYB561D2 cytochrome b561 family, member D2 -2.1228
ACOT13 acyl-CoA thioesterase 13 -2.10545
TNNC1 troponin C type 1 (slow) -2.10407
MRPL33 mitochondrial ribosomal protein L33 -2.07845
S100A14 S100 calcium binding protein A14 -2.0727
GPC4 glypican 4 -2.06628
SUGCT succinyl-CoA:glutarate-CoA transferase -2.06375
LTA lymphotoxin alpha -2.04365
RETREG1 reticulophagy regulator 1 -2.03653
MVD mevalonate (diphospho) decarboxylase -2.02895
REX1BD required for excision 1-B domain containing -2.02605
APEH acylaminoacyl-peptide hydrolase -2.02425
PI3 peptidase inhibitor 3, skin-derived -2.02322
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.01995
ECM1 extracellular matrix protein 1 -2.0196
RHOB ras homolog family member B -2.0038