CRCGN017_MCF10A.WT.HP_24H:A10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,3',4,4'-tetrachloro-1,1'-biphenyl 102.01 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 5.2841
ABHD6 abhydrolase domain containing 6 5.03702
FKBP14 FK506 binding protein 14, 22 kDa 4.6179
SPAG4 sperm associated antigen 4 4.1096
COL11A1 collagen, type XI, alpha 1 3.94357
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.75275
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.48067
OLFML2B olfactomedin-like 2B 3.328
WIF1 WNT inhibitory factor 1 3.14935
ACAA1 acetyl-CoA acyltransferase 1 2.9673
TIAM1 T-cell lymphoma invasion and metastasis 1 2.9023
PRRX1 paired related homeobox 1 2.52215
NAP1L3 nucleosome assembly protein 1-like 3 2.44685
TENM3 teneurin transmembrane protein 3 2.4448
RIOX1 ribosomal oxygenase 1 2.39265
ECD ecdysoneless homolog (Drosophila) 2.3811
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.2429
RGS18 regulator of G-protein signaling 18 2.2117
URGCP upregulator of cell proliferation 2.14445
PUS1 pseudouridylate synthase 1 2.1335
CADM1 cell adhesion molecule 1 2.12908
CCL21 chemokine (C-C motif) ligand 21 2.04585
FMOD fibromodulin 2.0333
VPREB3 pre-B lymphocyte 3 2.0302

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -4.5011
PRPF4 pre-mRNA processing factor 4 -4.111
TCTA T-cell leukemia translocation altered -4.0439
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.93247
MBOAT7 membrane bound O-acyltransferase domain containing 7 -3.66127
BAD BCL2-associated agonist of cell death -2.5591
NGRN neugrin, neurite outgrowth associated -2.55875
GOLGA1 golgin A1 -2.54663
STAT1 signal transducer and activator of transcription 1, 91kDa -2.49065
KLF7 Kruppel-like factor 7 (ubiquitous) -2.48215
BSPRY B-box and SPRY domain containing -2.40085
UBAP1 ubiquitin associated protein 1 -2.35445
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.35
GADD45B growth arrest and DNA-damage-inducible, beta -2.3359
CRIPT cysteine-rich PDZ-binding protein -2.2946
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -2.22585
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.17235
CHMP5 charged multivesicular body protein 5 -2.1468
ABITRAM actin binding transcription modulator -2.11355
RALGDS ral guanine nucleotide dissociation stimulator -2.11182
HSDL2 hydroxysteroid dehydrogenase like 2 -2.1095
TZMP1 transition zone microprotein 1 -2.07395
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -2.0355
WHR1 winged helix repair factor 1 -2.02602
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.0228
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -2.00505