CRCGN017_MCF10A.WT.HP_24H:A11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,3',4,4'-tetrachloro-1,1'-biphenyl 34.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WFS1 Wolfram syndrome 1 (wolframin) 5.26785
SSBP2 single-stranded DNA binding protein 2 4.69077
CXCR4 chemokine (C-X-C motif) receptor 4 4.38308
ACAA1 acetyl-CoA acyltransferase 1 3.01108
MAPK9 mitogen-activated protein kinase 9 2.94775
FBXO7 F-box protein 7 2.52305
CADM1 cell adhesion molecule 1 2.07285
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.045
MMP2 matrix metallopeptidase 2 2.02235

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -5.0
KIF14 kinesin family member 14 -4.72735
PRPF4 pre-mRNA processing factor 4 -4.38355
CREG1 cellular repressor of E1A-stimulated genes 1 -3.8576
SAP30BP SAP30 binding protein -3.7411
TMEM94 transmembrane protein 94 -3.37715
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.1152
MSN moesin -2.85375
ARID4B AT rich interactive domain 4B (RBP1-like) -2.81935
PRCP prolylcarboxypeptidase (angiotensinase C) -2.7137
RBM34 RNA binding motif protein 34 -2.65647
GRB2 growth factor receptor-bound protein 2 -2.63915
MRPS7 mitochondrial ribosomal protein S7 -2.52635
KRT14 keratin 14, type I -2.5172
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.4183
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.41225
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.3841
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.37085
FAM131A family with sequence similarity 131, member A -2.34295
BASP1 brain abundant, membrane attached signal protein 1 -2.3423
KCTD2 potassium channel tetramerization domain containing 2 -2.28052
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.2774
ATP5PD ATP synthase peripheral stalk subunit d -2.26545
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.24255
MRPL58 mitochondrial ribosomal protein L58 -2.20665
FKTN fukutin -2.09635
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.0774
NTS neurotensin -2.0704
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.06465
CD81 CD81 molecule -2.04865
TTF1 transcription termination factor, RNA polymerase I -2.03452
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.0284
IPP intracisternal A particle-promoted polypeptide -2.01085