CRCGN017_MCF10A.WT.HP_24H:A18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description galangin 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

193 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AURKB aurora kinase B 4.57505
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.1071
WASHC5 WASH complex subunit 5 3.9174
WASF3 WAS protein family, member 3 3.8732
ISOC1 isochorismatase domain containing 1 3.8715
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.79705
PROS1 protein S (alpha) 3.7528
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.72848
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 3.6635
PFKL phosphofructokinase, liver 3.64952
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.43475
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.427
TGFB3 transforming growth factor, beta 3 3.4258
MMP2 matrix metallopeptidase 2 3.37755
PRKX protein kinase, X-linked 3.3439
MYL9 myosin, light chain 9, regulatory 3.1994
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 3.1807
ALAS1 5'-aminolevulinate synthase 1 3.15
CADM1 cell adhesion molecule 1 3.13723
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.13455
ZNF232 zinc finger protein 232 3.05335
ZBTB35 zinc finger and BTB domain containing 35 2.98093
KDM5A lysine (K)-specific demethylase 5A 2.9331
ACAA1 acetyl-CoA acyltransferase 1 2.90097
SNX7 sorting nexin 7 2.8805
CERK ceramide kinase 2.8082
ZC2HC1A zinc finger, C2HC-type containing 1A 2.796
ZNF589 zinc finger protein 589 2.76458
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.71995
CSRNP3 cysteine-serine-rich nuclear protein 3 2.6783
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.67825
LOC102724560 cystathionine beta-synthase 2.66895
ICE1 interactor of little elongation complex ELL subunit 1 2.6446
MED22 mediator complex subunit 22 2.61015
IGFBP3 insulin-like growth factor binding protein 3 2.59985
CRYBG3 beta-gamma crystallin domain containing 3 2.5807
GRPR gastrin-releasing peptide receptor 2.5486
TRIB1 tribbles pseudokinase 1 2.5348
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.5223
TENT4A terminal nucleotidyltransferase 4A 2.5075
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.50605
UPP1 uridine phosphorylase 1 2.47
PLVAP plasmalemma vesicle associated protein 2.4507
EML1 echinoderm microtubule associated protein like 1 2.45047
CREB1 cAMP responsive element binding protein 1 2.42894
GSTM2 glutathione S-transferase mu 2 (muscle) 2.42292
GCH1 GTP cyclohydrolase 1 2.41485
PMM2 phosphomannomutase 2 2.4032
TRIB3 tribbles pseudokinase 3 2.38965
DSCC1 DNA replication and sister chromatid cohesion 1 2.36725
CHEK1 checkpoint kinase 1 2.33125
DDR2 discoidin domain receptor tyrosine kinase 2 2.32755
JRKL JRK-like 2.327
PRR16 proline rich 16 2.3112
C5 complement component 5 2.3057
CPE carboxypeptidase E 2.29653
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.29585
KRT76 keratin 76, type II 2.29225
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.29215
GRK5 G protein-coupled receptor kinase 5 2.27665
CAMK1 calcium/calmodulin-dependent protein kinase I 2.27445
RSU1 Ras suppressor protein 1 2.2735
HMGA2 high mobility group AT-hook 2 2.27335
ANKRD49 ankyrin repeat domain 49 2.26595
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.2633
NOL11 nucleolar protein 11 2.25575
KCTD11 potassium channel tetramerization domain containing 11 2.25515
SST somatostatin 2.23475
CLIP2 CAP-GLY domain containing linker protein 2 2.20735
HSF4 heat shock transcription factor 4 2.2012
CNMD chondromodulin 2.1949
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.18445
DRG2 developmentally regulated GTP binding protein 2 2.18197
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.17997
MED17 mediator complex subunit 17 2.17985
DROSHA drosha, ribonuclease type III 2.17
SCGN secretagogin, EF-hand calcium binding protein 2.1668
TIMCC TIM double twin CX3C motif chaperone 2.16635
DPP4 dipeptidyl-peptidase 4 2.16503
PDE7B phosphodiesterase 7B 2.16215
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.15875
CEP170B centrosomal protein 170B 2.1584
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.1578
TIMP2 TIMP metallopeptidase inhibitor 2 2.1437
DRP2 dystrophin related protein 2 2.1412
CYRIA CYFIP related Rac1 interactor A 2.13075
TCEA2 transcription elongation factor A (SII), 2 2.129
SARS2 seryl-tRNA synthetase 2, mitochondrial 2.11455
JMJD4 jumonji domain containing 4 2.10905
PRDM14 PR domain containing 14 2.1006
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.09567
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.09385
IL22RA1 interleukin 22 receptor, alpha 1 2.0937
ARHGAP9 Rho GTPase activating protein 9 2.08615
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.0854
ENTREP1 endosomal transmembrane epsin interactor 1 2.079
SIX6 SIX homeobox 6 2.07815
ZNF559-ZNF177 ZNF559-ZNF177 readthrough 2.0775
LRP2 low density lipoprotein receptor-related protein 2 2.06925
CAPN10 calpain 10 2.06915
PSKH1 protein serine kinase H1 2.0667
NECTIN3 nectin cell adhesion molecule 3 2.0506
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.03875
USP21 ubiquitin specific peptidase 21 2.0272
BYSL bystin-like 2.0257
DICER1 dicer 1, ribonuclease type III 2.01876
SCG2 secretogranin II 2.0154
BCAT1 branched chain amino-acid transaminase 1, cytosolic 2.0098

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -6.6736
TNIP1 TNFAIP3 interacting protein 1 -6.1665
BASP1 brain abundant, membrane attached signal protein 1 -5.198
CD81 CD81 molecule -4.9425
MSMO1 methylsterol monooxygenase 1 -4.16195
ARID4B AT rich interactive domain 4B (RBP1-like) -3.63805
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.58695
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.1995
SCYL3 SCY1-like 3 (S. cerevisiae) -3.06698
TM9SF2 transmembrane 9 superfamily member 2 -3.03775
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.95675
ILK integrin-linked kinase -2.81435
ITGB6 integrin, beta 6 -2.81178
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.7897
DCAF6 DDB1 and CUL4 associated factor 6 -2.77295
KAT7 K(lysine) acetyltransferase 7 -2.7312
AQP3 aquaporin 3 (Gill blood group) -2.71618
REPS2 RALBP1 associated Eps domain containing 2 -2.6795
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.66785
TKT transketolase -2.62385
DDIT4 DNA-damage-inducible transcript 4 -2.59475
STMN1 stathmin 1 -2.58275
CSK c-src tyrosine kinase -2.55095
SH3D19 SH3 domain containing 19 -2.54017
TMEM9B TMEM9 domain family, member B -2.50075
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.49475
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.492
SLC44A4 solute carrier family 44, member 4 -2.49065
BAG1 BCL2-associated athanogene -2.4864
DSG2 desmoglein 2 -2.48065
TM9SF3 transmembrane 9 superfamily member 3 -2.44085
EMC3 ER membrane protein complex subunit 3 -2.4139
RETREG3 reticulophagy regulator family member 3 -2.4041
IGFBP7 insulin-like growth factor binding protein 7 -2.39162
UFM1 ubiquitin-fold modifier 1 -2.37405
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.37265
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.3619
NBR1 neighbor of BRCA1 gene 1 -2.36182
OSBPL9 oxysterol binding protein-like 9 -2.35545
LRP10 low density lipoprotein receptor-related protein 10 -2.32395
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.3171
FAM53C family with sequence similarity 53, member C -2.313
TOR1AIP2 torsin A interacting protein 2 -2.3122
CSTA cystatin A (stefin A) -2.31175
MED24 mediator complex subunit 24 -2.30915
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.297
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.2923
MARF1 meiosis regulator and mRNA stability factor 1 -2.28055
ALOX15 arachidonate 15-lipoxygenase -2.25445
RNF11 ring finger protein 11 -2.24955
GDF15 growth differentiation factor 15 -2.23625
RNFT1-DT RNFT1 divergent transcript -2.2315
MRPL49 mitochondrial ribosomal protein L49 -2.22915
BUD31 BUD31 homolog (S. cerevisiae) -2.22795
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.21645
ADI1 acireductone dioxygenase 1 -2.1979
JMJD7 jumonji domain containing 7 -2.18215
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.1721
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.1661
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.1628
RAB13 RAB13, member RAS oncogene family -2.13815
RAB1B RAB1B, member RAS oncogene family -2.1355
RNMT RNA (guanine-7-) methyltransferase -2.12308
ATOX1 antioxidant 1 copper chaperone -2.1229
GADD45B growth arrest and DNA-damage-inducible, beta -2.12165
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -2.12077
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.1143
SGK1 serum/glucocorticoid regulated kinase 1 -2.1132
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.09917
MGST3 microsomal glutathione S-transferase 3 -2.0964
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.09325
GFUS GDP-L-fucose synthase -2.0865
EFNA3 ephrin-A3 -2.0853
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.07115
RPN1 ribophorin I -2.05705
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.05268
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.05115
PHF2 PHD finger protein 2 -2.04905
TMEM59 transmembrane protein 59 -2.03205
MUC4 mucin 4, cell surface associated -2.02707
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.021
LDHD lactate dehydrogenase D -2.01765
DTD1 D-tyrosyl-tRNA deacylase 1 -2.0093
UBE2C ubiquitin-conjugating enzyme E2C -2.0081
FBRS fibrosin -2.0038