CRCGN017_MCF10A.WT.HP_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo[a,l]pyrene 32.41 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.1113
TBX2 T-box 2 4.17895
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.03742
KLHL9 kelch-like family member 9 3.32438
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.12845
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.11875
CCL2 chemokine (C-C motif) ligand 2 2.52665
AGR2 anterior gradient 2 2.5195
NOSIP nitric oxide synthase interacting protein 2.4703
ZBTB35 zinc finger and BTB domain containing 35 2.433
RBBP5 retinoblastoma binding protein 5 2.34465
SCARA3 scavenger receptor class A, member 3 2.18615
DDB1 damage-specific DNA binding protein 1, 127kDa 2.1748
CENPM centromere protein M 2.078
ECD ecdysoneless homolog (Drosophila) 2.0091

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -5.3513
PCCB propionyl CoA carboxylase, beta polypeptide -4.7229
GNAS GNAS complex locus -4.45917
HMG20B high mobility group 20B -4.45728
MT2A metallothionein 2A -3.50165
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.4786
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.37025
SGK1 serum/glucocorticoid regulated kinase 1 -3.13265
SAP30BP SAP30 binding protein -3.0894
KCTD2 potassium channel tetramerization domain containing 2 -2.68055
NELFCD negative elongation factor complex member C/D -2.6275
NGRN neugrin, neurite outgrowth associated -2.5188
TMEM94 transmembrane protein 94 -2.4653
MRPL58 mitochondrial ribosomal protein L58 -2.4528
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.44145
BPHL biphenyl hydrolase-like (serine hydrolase) -2.4116
ATP5F1E ATP synthase F1 subunit epsilon -2.40975
CDR2L cerebellar degeneration-related protein 2-like -2.3883
RPL38 ribosomal protein L38 -2.3572
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.2864
NCAM2 neural cell adhesion molecule 2 -2.2204
DOK2 docking protein 2, 56kDa -2.19685
MRPS7 mitochondrial ribosomal protein S7 -2.1938
GADD45B growth arrest and DNA-damage-inducible, beta -2.18818
NTM neurotrimin -2.15595
WASHC4 WASH complex subunit 4 -2.15475
PGAP6 post-GPI attachment to proteins 6 -2.1528
MTERF3 mitochondrial transcription termination factor 3 -2.1184
ZNF250 zinc finger protein 250 -2.08455
CYBC1 cytochrome b-245 chaperone 1 -2.054
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.0522
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.0437
SUMO4 small ubiquitin-like modifier 4 -2.0219
ARMC7 armadillo repeat containing 7 -2.01735