CRCGN017_MCF10A.WT.HP_24H:A22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ammonium-perfluorocaprylate 98.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LOXL1 lysyl oxidase-like 1 5.112
AXIN1 axin 1 4.4535
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.09483
RAB31 RAB31, member RAS oncogene family 3.66267
ADRB2 adrenoceptor beta 2, surface 3.6487
CGRRF1 cell growth regulator with ring finger domain 1 2.7176
GSTZ1 glutathione S-transferase zeta 1 2.62715
PFDN1 prefoldin subunit 1 2.3984
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough 2.3812
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.35495
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.3262
ZNF589 zinc finger protein 589 2.30698
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.26195
FCHO1 FCH domain only 1 2.1601
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.15635
MEPCE methylphosphate capping enzyme 2.0728
LOC124906748 beta-defensin 4A 2.06715
LGALS8 lectin, galactoside-binding, soluble, 8 2.06142
SRP9 signal recognition particle 9kDa 2.04095
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.0165
PDIA5 protein disulfide isomerase family A, member 5 2.0149
MFAP4 microfibrillar-associated protein 4 2.0132

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -10.0
S100A8 S100 calcium binding protein A8 -5.00135
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.98085
PLK1 polo-like kinase 1 -3.90985
JMJD6 jumonji domain containing 6 -3.8602
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.3352
NT5DC2 5'-nucleotidase domain containing 2 -2.9477
MT2A metallothionein 2A -2.7802
KRT14 keratin 14, type I -2.75935
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.73095
ACAA1 acetyl-CoA acyltransferase 1 -2.56993
TRAP1 TNF receptor-associated protein 1 -2.46925
IGF2R insulin-like growth factor 2 receptor -2.45027
IGFBP7 insulin-like growth factor binding protein 7 -2.44895
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.4463
QPRT quinolinate phosphoribosyltransferase -2.4178
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -2.377
DUSP9 dual specificity phosphatase 9 -2.34405
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.32811
RAB29 RAB29, member RAS oncogene family -2.29383
NGRN neugrin, neurite outgrowth associated -2.18815
SCRIB scribbled planar cell polarity protein -2.1117
EFNA3 ephrin-A3 -2.09785
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.0934
RGN regucalcin -2.0725
LRP5 low density lipoprotein receptor-related protein 5 -2.05505
MT1X metallothionein 1X -2.0514
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.00355